Molecular Basis of Interferon Action

Verhaegen-Lewalle, Martine

doi:10.1007/978-1-4684-7718-4_23

Cell Regulation by Intracellular Signals 1982

DOI: 10.1007/978-1-4684-7718-4_23

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Molecular Basis of Interferon Action

Martine Verhaegen-Lewalle

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1982

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2′‐Phosphodiesterase Activity in Human Cell Lines Treated or Untreated with Human Interferon

Verhaegen-Lewalle¹

1982

European Journal of Biochemistry

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2′‐Phosphodiesterase activity was investigated, by measuring either the disappearance of (2′‐5′)oligo(adenylate) or the release of 5′AMP, in several human cell lines (RSa, IFr, HEC‐1, WGAr and HeLa) possessing different sensitivities to interferon, and treated or untreated with human interferon. In various cell lines whose (2′‐5′)‐oligo(adenylate) synthetase was normally induced by interferon treatment, both kinetic studies and measurements at different enzyme concentrations indicated that 2′‐phosphodiesterase activity remained unchanged after interferon treatment. This observation was confirmed over a broad range of substrate concentrations (1–2500 nM). The activity of 2′‐phosphodiesterase was dependent on Mg(OAc)2. Our results indicate that in various human cell lines the modulation of (2′‐5′)oligo(adenylate) metabolism by interferon does not involve an increase of 2′‐phosphodiesterase activity.

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2′‐Phosphodiesterase Activity in Human Cell Lines Treated or Untreated with Human Interferon

Verhaegen-Lewalle¹

1982

European Journal of Biochemistry

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Molecular Basis of Interferon Action

Cited by 1 publication

References 77 publications

2′‐Phosphodiesterase Activity in Human Cell Lines Treated or Untreated with Human Interferon

2′‐Phosphodiesterase Activity in Human Cell Lines Treated or Untreated with Human Interferon

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