Molecular basis of the interaction of novel tributyltin(IV) 2/4-[(E)-2-(aryl)-1-diazenyl]benzoates endowed with an improved cytotoxic profile: Synthesis, structure, biological efficacy and QSAR studies

Synthesis, characterization and crystal structures of 2-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)-1-diazenyl]benzoic acid and its polymeric and monomeric triorganotin(IV) complexes

“…has a distorted C 3 O tetrahedral geometry involving one of the carboxylate O atoms and three C atoms from the butyl ligands [3]. On the other hand, its ortho-carboxy analogue i.e.…”

“…a distorted tetrahedral geometry [10]. In view of the synthetic and structural importance and the potential biological activity of the triorganotin(IV) complexes of the aforementioned ligands, it is of interest to explore the chemistry of the analogous ligands towards triorganotin(IV)…”

“…Further, these ligands and their analogues have been explored for their coordination behaviour towards organotin(IV) in order to find possible candidates in this class of organotin(IV) complexes which might act as anticancer drugs owing to their remarkable cytotoxic activity that has been exhibited in some cases across a panel of cell lines [3][4][5]. As a result of promising cytotoxic activity [6,7], the mechanistic role of these organotin(IV) compounds was investigated, to see influence of the azo group nitrogen atoms, by docking studies with some of the key enzymes such as ribonucleotide reductase, thymidylate synthase, thymidylate phosphorylase and topoisomerase II that take part in the synthesis of raw materials for DNA and its replication [3][4][5]. The docking studies indicated that the azo group nitrogen atoms and formyl, carbonyl and ester oxygen atoms in the ligand moiety play an important role.…”

Sulfonated Schiff base Sn(IV) complexes as potential anticancer agents

“…Amongst them, organotin(IV) compounds have been extensively explored and some of them exhibit a remarkable in vitro anti-tumor activity [19][20][21][22][23][24][25][26][27][28][29][30][31][32][39][40][41][42][43][44][45][46][47][48][49][50][51][52], namely in view of their apoptosis inducing character [19][20][21][22][23][24][25][26][27][28][29][30][31][32].…”

“…Thus, the design of improved organotin(IV) antitumor agents occupies a significant place in cancer chemotherapy research [19][20][21][22][23][24][25][26][27][28][29][30][31][32], and the synthesis of such a type of complexes with a potential anti-cancer significance presents a primary objective of the current study.…”