Molecular biomarkers added to image-enhanced endoscopic imaging: Will they further improve diagnostic accuracy?

Krishnamoorthi, Rajesh; Iyer, Prasad G.

doi:10.1016/j.bpg.2015.05.012

Cited by 8 publications

(7 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of these candidate markers include P53 expression, 46,47 copy number changes in chromosomes detected by fluorescent in situ hybridization (FISH), methylated DNA markers, and other panels of molecular epithelial and stromal markers. 48 The ultimate goal of these clinical and biomarker panels would be to identify low-risk and high-risk groups that could be either discharged from surveillance (low-risk group) or managed with intensive surveillance or proactive ablation (high-risk group).…”

Section: Management Of Patients With Be Proton Pump Inhibitor Therapymentioning

confidence: 99%

Barrett Esophagus

Iyer

Kaul

2019

Mayo Clinic Proceedings

Self Cite

View full text Add to dashboard Cite

The target audience for Mayo Clinic Proceedings is primarily internal medicine physicians and other clinicians who wish to advance their current knowledge of clinical medicine and who wish to stay abreast of advances in medical research. Statement of Need: General internists and primary care physicians must maintain an extensive knowledge base on a wide variety of topics covering all body systems as well as common and uncommon disorders. Mayo Clinic Proceedings aims to leverage the expertise of its authors to help physicians understand best practices in diagnosis and management of conditions encountered in the clinical setting. Accreditation: In support of improving patient care, Mayo Clinic College of Medicine and Science is accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team. Credit Statement: Mayo Clinic College of Medicine and Science designates this journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s).ä Physicians should claim only the credit commensurate with the extent of their participation in the activity. MOC Credit Statement: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1 MOC point in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Learning Objectives: On completion of this article, you should be able to (1) obtain state of the art information related to screening and surveillance in Barrett esophagus, (2) acquire a good understanding of the various modalities of treatment available for dysplastic Barrett esophagus and early esophageal neoplasia, and (3) identify the key best practices and guideline based recommendations for management of Barrett esophagus. Disclosures: As a provider accredited by ACCME, Mayo Clinic College of Medicine and Science (Mayo School of Continuous Professional Development) must ensure balance, independence, objectivity, and scientific rigor in its educational activities. Course Director(s), Planning Committee members, Faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of this information will be published in course materials so that those participants in the activity may formulate their...

show abstract

Section: Management Of Patients With Be Proton Pump Inhibitor Therapymentioning

confidence: 99%

Barrett Esophagus

Iyer

Kaul

2019

Mayo Clinic Proceedings

Self Cite

View full text Add to dashboard Cite

show abstract

“…WLE detects cancerous lesions based on structural changes or discoloration of the epithelial surface 1 and may be used to guide the acquisition of tissue biopsies. 4 Unfortunately, precancerous lesions, such as dysplasia, are often flat and do not exhibit detectable discoloration relative to normal tissue in the normal three reflectance color channels (RGB) used in WLE. 1,4 This makes disease detection and acquisition of targeted biopsies with conventional WLE challenging.…”

Section: Introductionmentioning

confidence: 99%

“…4 Unfortunately, precancerous lesions, such as dysplasia, are often flat and do not exhibit detectable discoloration relative to normal tissue in the normal three reflectance color channels (RGB) used in WLE. 1,4 This makes disease detection and acquisition of targeted biopsies with conventional WLE challenging. 1,4 Consequently, there is a strong clinical interest in the development of new endoscopic screening methods that may enhance the contrast for precancerous lesions, enabling better targeting of biopsies and improving diagnostic performance.…”

Section: Introductionmentioning

confidence: 99%

“…1,4 This makes disease detection and acquisition of targeted biopsies with conventional WLE challenging. 1,4 Consequently, there is a strong clinical interest in the development of new endoscopic screening methods that may enhance the contrast for precancerous lesions, enabling better targeting of biopsies and improving diagnostic performance. 1,[4][5][6][7][8][9][10] Multimodal endoscopy holds potential to improve the diagnostic performance of endoscopic cancer screening 11 by simultaneously interrogating numerous contrast mechanisms linked to cancer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bimodal reflectance and fluorescence multispectral endoscopy based on spectrally resolving detector arrays

et al. 2018

View full text Add to dashboard Cite

Emerging clinical interest in combining standard white light endoscopy with targeted near-infrared (NIR) fluorescent contrast agents for improved early cancer detection has created demand for multimodal imaging endoscopes. We used two spectrally resolving detector arrays (SRDAs) to realize a bimodal endoscope capable of simultaneous reflectance-based imaging in the visible spectral region and multiplexed fluorescencebased imaging in the NIR. The visible SRDA was composed of 16 spectral bands, with peak wavelengths in the range of 463 to 648 nm and full-width at half-maximum (FWHM) between 9 and 26 nm. The NIR SRDA was composed of 25 spectral bands, with peak wavelengths in the range 659 to 891 nm and FWHM 7 to 15 nm. The spectral endoscope design was based on a "babyscope" model using a commercially available imaging fiber bundle. We developed a spectral transmission model to select optical components and provide reference endmembers for linear spectral unmixing of the recorded image data. The technical characterization of the spectral endoscope is presented, including evaluation of the angular field-of-view, barrel distortion, spatial resolution and spectral fidelity, which showed encouraging performance. An agarose phantom containing oxygenated and deoxygenated blood with three fluorescent dyes was then imaged. After spectral unmixing, the different chemical components of the phantom could be successfully identified via majority decision with high signal-to-background ratio (>3). Imaging performance was further assessed in an ex vivo porcine esophagus model. Our preliminary imaging results demonstrate the capability to simultaneously resolve multiple biological components using a compact spectral endoscopy system.

show abstract

“…One example is the integration of multispectral imaging (MSI), which enables both spatial (x, y) and spectral (wavelength, λ) information to be recorded from the tissue. MSI can extend the acquisition of spectral image data beyond the current clinically implemented endoscopic methods of autofluorescence imaging and dye-based or virtual chromoendoscopy 13 . Spectral data contains chemical information about the composition of the tissue and has been demonstrated in a wide range of potential applications in biomedical imaging 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of comb-structure correction methods for multispectral fibrescopic imaging

Waterhouse

Luthman

Yoon

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Removing the comb artifact introduced by imaging fibre bundles, or ‘fibrescopes’, for example in medical endoscopy, is essential to provide high quality images to the observer. Multispectral imaging (MSI) is an emerging method that combines morphological (spatial) and chemical (spectral) information in a single data ‘cube’. When a fibrescope is coupled to a spectrally resolved detector array (SRDA) to perform MSI, comb removal is complicated by the demosaicking step required to reconstruct the multispectral data cube. To understand the potential for using SRDAs as multispectral imaging sensors in medical endoscopy, we assessed five comb correction methods with respect to five performance metrics relevant to biomedical imaging applications: processing time, resolution, smoothness, signal and the accuracy of spectral reconstruction. By assigning weights to each metric, which are determined by the particular imaging application, our results can be used to select the correction method to achieve best overall performance. In most cases, interpolation gave the best compromise between the different performance metrics when imaging using an SRDA.

show abstract

Molecular biomarkers added to image-enhanced endoscopic imaging: Will they further improve diagnostic accuracy?

Cited by 8 publications

References 57 publications

Barrett Esophagus

Barrett Esophagus

Bimodal reflectance and fluorescence multispectral endoscopy based on spectrally resolving detector arrays

Quantitative evaluation of comb-structure correction methods for multispectral fibrescopic imaging

Contact Info

Product

Resources

About