Molecular Changes in Circulating microRNAs’ Expression and Oxidative Stress in Adults with Mild Cognitive Impairment: A Biochemical and Molecular Study

Al-Rawaf, Hadeel A.; Alghadir, Ahmad H.; Gabr, Sami A.

doi:10.2147/cia.s285689

Cited by 20 publications

(7 citation statements)

References 128 publications

(219 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, “recent and previous research works reported a significant association between cellular oxidative stress measured by nitric oxide (NO), lipid peroxide malondialdehyde (MDA), imbalance in antioxidant status measured by cellular enzymes superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity, and different inflammatory cytokines in subjects with cognitive impairments at different ages” ( Li et al, 2016 , Alghadir et al, 2021 , Al-Rawaf et al, 2021 , Kandlur et al, 2020 , Padurariu et al, 2010 , Baierle et al, 2015 , Alghadir et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Associations between glutamic acid decarboxylase antibodies, oxidative stress markers, and cognitive capacity in adolescents who stutter

Almudhi

Gabr

2023

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Associations between glutamic acid decarboxylase antibodies, oxidative stress markers, and cognitive capacity in adolescents who stutter

Almudhi

Gabr

2023

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

“…41 The production and release of a large number of ROS in neurons necroptosis process can regulate synaptic and non-synaptic information transmission between neurons and glial cells, and promote neuronal degeneration in the form of neuroinflammation and cell death, leading to memory loss and cognitive impairment. 42 study, after the application of Res to PTX-induced cognitive impairment mice, the expression of BDNF and PSD95 increased significantly, speeding up the efficiency of synaptic transmission, and improving the cognitive function of mice. These results clearly demonstrated the neuroprotective efficacy of Res in preventing synaptic plasticity damage from PTX.…”

Section: Discussionmentioning

confidence: 90%

Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization

Liu¹,

Tang²,

He³

et al. 2023

DDDT

View full text Add to dashboard Cite

Objective This study aimed to investigate the effect of resveratrol (Res) on paclitaxel (PTX)-induced cognitive impairment and elucidate the underlying molecular mechanisms. Methods Morris Water Maze (MWM) test was used to evaluate the mice’s spatial learning and memory abilities. Western blotting was applied to detect protein expression of receptor-interacting protein (RIP3), mixed lineage kinase domain-like protein (MLKL), silencing information regulator 2 related enzyme 1 (SIRT1), peroxisome proliferator activated receptor coactivator-1 (PGC-1α), NADPH oxidase 2 (NOX2), NOX4, postsynaptic density zone 95 (PSD95), arginase-1 (Arg-1) and inducible nitric oxide synthase (iNOS). Immunofluorescence of RIP3, MLKL, Arg-1, Iba-1 and iNOS was conducted to observe the apoptosis of hippocampal cells and the polarization of microglia. qRT-PCR was performed to detect BDNF mRNA expressions. DHE staining was used to assess the level of oxidative stress response. Golgi-Cox staining and dendritic spine counting were applied to visualize synaptic structural plasticity. Postsynaptic density was performed by transmission electron microscope. ELISA was used to detect the contents of tumour necrosis factor alpha (TNF-α), IL-1β, IL-4, and IL-10. Results PTX-induced cognitive impairment model was constructed after the application of PTX, represented as longer latency to platform and less platform crossing times over the whole period in PTX group. After Res treatment, the above indicators were reversed, indicating that cognitive function was improved. Moreover, Res reduced neuronal apoptosis and oxidative stress through SIRT1/PGC-1α pathway in mice, manifesting as down-regulated expression of RIP3, MLKL, NOX2 and NOX4. Meanwhile, Res increased the density of dendritic spines and the expression of PSD95 and BDNF, thereby ameliorating the PTX induced synaptic damage. Besides, M2 microglia was in the majority, eliciting the expression of anti-inflammatory cytokines IL-4 and IL-10 after Res treatment in PTX+Res group, while immunofluorescence images results demonstrated an decrease in the proportion of M2 microglia a following SIRT1 inhibitor EX-527. Conclusion Res improves PTX-induced cognitive impairment in mice by activating SIRT1/PGC-1α pathways to regulate neuronal state and microglia cell polarization.

show abstract

“…Forty-nine articles were assessed in the systematic review and three of those studies could not be included in the MA for reasons shown in ESF Table 4. As a result, the meta-analysis was performed on 46 studies (Al-Rawaf et al, 2021;Arce-Varas et al, 2017;Ayromlou et al, 2018;Balmus et al, 2017;Bermejo et al, 2008;Boccardi et al, 2021;Cervellati et al, 2013;Cervellati et al, 2014a;Cervellati et al, 2014b;Chico et al, 2013;Chmatalova et al, 2017;Dong et al, 2008;Du et al, 2019;Gironi et al, 2011;Gironi et al, 2015;Guidi et al, 2006;Gunduztepe et al, 2020;He et al, 2016;Irizarry et al, 2007;Iuliano et al, 2010;Kim et al, 2013;Lanyau-Domínguez et al, 2020;Lee et al, 2013;Liu et al, 2016;Lopez et al, 2013;Ma et al, 2017;Martin-Aragon et al, 2009;Martinez de Toda et al, 2019;McFarlane et al, 2020;Mota et al, 2015;Mueller et al, 2012;Mufson and Leurgans, 2010;Negahdar et al, 2015;Padurariu et al, 2010;Perrotte et al, 2019;Praticò et al, 2002;Rembach et al, 2013;Rinaldi et al, 2003;…”

Section: Search Resultsmentioning

confidence: 99%

Oxidative stress and antioxidant defenses in mild cognitive impairment: a systematic review and meta-analysis

Nantachai

Maes

Tunvirachaisakul

et al. 2021

Preprint

View full text Add to dashboard Cite

This study aims to systematically review and meta-analyze the nitro-oxidative stress (O&NS)/antioxidant (ANTIOX) ratio in the peripheral blood of people with mild cognitive impairment (MCI). We searched PubMed, Scopus, Google Scholar, and Web of Science for articles published from inception until July 31, 2021. Forty-six studies on 3.798 MCI individuals and 6.063 healthy controls were included. The O&NS/ANTIOX ratio was significantly higher in MCI than in controls with a Standardized Mean Difference (SMD)=0.378 (95% CI: 0.250; 0.506). MCI individuals showed increased lipid peroxidation (SMD=0.774, 95%CI: 4.416; 1.132) and O&NS-associated toxicity (SMD=0.621, CI: 0.377; 0.865) and reduced glutathione (GSH) defenses (SMD=0.725, 95%CI: 0.269; 1.182) as compared with controls. MCI was also accompanied by significantly increased homocysteine (SMD=0.320, CI: 0.059; 0.581), but not protein oxidation, and lowered non-vitamin (SMD=0.347, CI: 0.168; 0.527) and vitamin (SMD=0.564, CI: 0.129; 0.999) antioxidant defenses. The results show that MCI is at least in part due to increased neuro-oxidative toxicity and suggest that treatments targeting lipid peroxidation and the GSH system may be used to treat or prevent MCI.

show abstract

Molecular Changes in Circulating microRNAs’ Expression and Oxidative Stress in Adults with Mild Cognitive Impairment: A Biochemical and Molecular Study

Cited by 20 publications

References 128 publications

Associations between glutamic acid decarboxylase antibodies, oxidative stress markers, and cognitive capacity in adolescents who stutter

Associations between glutamic acid decarboxylase antibodies, oxidative stress markers, and cognitive capacity in adolescents who stutter

Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization

Oxidative stress and antioxidant defenses in mild cognitive impairment: a systematic review and meta-analysis

Contact Info

Product

Resources

About