Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease

Baier, Claas; Haid, Sibylle; Beilken, Andreas; Behnert, Astrid; Wetzke, Martin; Brown, Richard J. P.; Schmitt, Corinna; Ebadi, Ella; Hansen, Gesine; Schulz, Thomas F.; Pietschmann, Thomas; Bange, Franz-Christoph

doi:10.1186/s13756-018-0316-2

Cited by 7 publications

(10 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, a recent study conducted in special high-risk settings such as hematology and oncology units, suggests that the diagnoses of asymptomatic virus infections, such as RSV and influenza, can be useful to lower the risk of hospital acquisition. The screening program proved useful for identifying asymptomatically infected patients with viral shedding, thus reducing the risk of transmission and potential nosocomial clusters of RSV and influenza virus on hemato-oncological wards (Baier et al, 2018).…”

Section: Can Multiplex Platforms Reduce the Medical And Socioeconomicmentioning

confidence: 99%

Multiplex Platforms for the Identification of Respiratory Pathogens: Are They Useful in Pediatric Clinical Practice?

Esposito

Mencacci

Cenci

et al. 2019

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Respiratory tract infections (RTIs) are extremely common especially in the first year of life. Knowledge of the etiology of a RTI is essential to facilitate the appropriate management and the implementation of the most effective control measures. This perspective explains why laboratory methods that can identify pathogens in respiratory secretions have been developed over the course of many years. High-complexity multiplex panel assays that can simultaneously detect up to 20 viruses and up to four bacteria within a few hours have been marketed. However, are these platforms actually useful in pediatric clinical practice? In this manuscript, we showed that these platforms appear to be particularly important for epidemiological studies and clinical research. On the contrary, their routine use in pediatric clinical practice remains debatable. They can be used only in the hospital as they require specific equipment and laboratory technicians with considerable knowledge, training, and experience. Moreover, despite more sensitive and specific than other tests routinely used for respiratory pathogen identification, they do not offer significantly advantage for detection of the true etiology of a respiratory disease. Furthermore, knowledge of which virus is the cause of a respiratory disease is not useful from a therapeutic point of view unless influenza virus or respiratory syncytial virus are the infecting agents as effective drugs are available only for these pathogens. On the other hand, multiplex platforms can be justified in the presence of severe clinical manifestations, and in immunocompromised patients for whom specific treatment option can be available, particularly when they can be used simultaneously with platforms that allow identification of antimicrobial resistance to commonly used drugs. It is highly likely that these platforms, particularly those with high sensitivity and specificity and with low turnaround time, will become essential when new drugs effective and safe against most of the respiratory viruses will be available. Further studies on how to differentiate carriers from patients with true disease, as well as studies on the implications of coinfections and identification of antimicrobial resistance, are warranted.

show abstract

Section: Can Multiplex Platforms Reduce the Medical And Socioeconomicmentioning

confidence: 99%

Multiplex Platforms for the Identification of Respiratory Pathogens: Are They Useful in Pediatric Clinical Practice?

Esposito

Mencacci

Cenci

et al. 2019

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Some practice-leading hospitals were also screening, and in some cases testing, all admissions for influenza and RSV during respiratory virus season, even before the current SARS-CoV-2 pandemic demonstrated the importance and potential benefits of admission screening. 44 80 A cluster randomized trial of point-of-care admission testing for influenza found that point-of-care admission testing was associated with higher rates of influenza diagnosis, more use of antiviral treatment, less time to initiation of antivirals, and almost double the rate of isolating influenza-positive patients in single patient rooms. 81 Another study associated the introduction of rapid early influenza tests for selected patients with a 75% decrease in hospital-acquired influenza cases.…”

Section: Symptom Screening and Universal Testingmentioning

confidence: 99%

New Insights into the Prevention of Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia Caused by Viruses

Klompas

2022

Semin Respir Crit Care Med

View full text Add to dashboard Cite

A fifth or more of hospital-acquired pneumonias may be attributable to respiratory viruses. The SARS-CoV-2 pandemic has clearly demonstrated the potential morbidity and mortality of respiratory viruses and the constant threat of nosocomial transmission and hospital-based clusters. Data from before the pandemic suggest the same can be true of influenza, respiratory syncytial virus, and other respiratory viruses. The pandemic has also helped clarify the primary mechanisms and risk factors for viral transmission. Respiratory viruses are primarily transmitted by respiratory aerosols that are routinely emitted when people exhale, talk, and cough. Labored breathing and coughing increase aerosol generation to a much greater extent than intubation, extubation, positive pressure ventilation, and other so-called aerosol-generating procedures. Transmission risk is proportional to the amount of viral exposure. Most transmissions take place over short distances because respiratory emissions are densest immediately adjacent to the source but then rapidly dilute and diffuse with distance leading to less viral exposure. The primary risk factors for transmission then are high viral loads, proximity, sustained exposure, and poor ventilation as these all increase net viral exposure. Poor ventilation increases the risk of long-distance transmission by allowing aerosol-borne viruses to accumulate over time leading to higher levels of exposure throughout an enclosed space. Surgical and procedural masks reduce viral exposure but do not eradicate it and thus lower but do not eliminate transmission risk. Most hospital-based clusters have been attributed to delayed diagnoses, transmission between roommates, and staff-to-patient infections. Strategies to prevent nosocomial respiratory viral infections include testing all patients upon admission, preventing healthcare providers from working while sick, assuring adequate ventilation, universal masking, and vaccinating both patients and healthcare workers.

show abstract

“…Za preprečevanje prenosa okužbe bi bilo otrokom z okužbo zgornjih dihalnih poti smiselno omejiti gibanje zgolj na domače okolje, vendar pa lahko to povzroči tudi socialno osamljenost (Baier et al, 2018). Tudi v času epidemije koronavirusne bolezni so bili otroci izpostavljeni socialni izolaciji, kar se kaže na njihovem duševnem zdravju.…”

Section: Raven Dokaza / Level Of Evidenceunclassified

Ukrepi za obravnavo otroka z okužbo zgornjih dihalnih poti

et al. 2021

View full text Add to dashboard Cite

Uvod: Okužbe zgornjih dihalnih poti so pri otrocih pogoste ter so tudi pogost razlog za opustitve šolanja, obisk zdravnika in nepotrebne stroške zdravstva. Namen raziskave je pregledati, analizirati in sintetizirati obstoječo literaturo s področja ukrepov pri zdravstveni obravnavi otrok z okužbo zgornjih dihalnih poti.Metode: Uporabili smo opisno metodo dela. Iskanje literature je potekalo v obdobju od decembra 2019 do januarja 2020 v mednarodnih podatkovnih bazah Medline in CINAHL. Potek iskanja in analize literature je prikazan s pomočjo diagrama PRISMA. Zadetke smo analizirali glede na karakteristike raziskav in razvrstili glede na raven dokaza. Rezultate smo sintetizirali s pomočjo vsebinske analize.Rezultati: Izmed 1.845 identificiranih zadetkov smo v končno analizo vključili 18 zadetkov. Identificirali smo 10 kategorij: znanje, prepoznavanje okužbe zgornjih dihalnih poti, predpisovanje in uporaba antibiotikov, uporaba nepredpisanih zdravil v domačem okolju, uporaba predpisanih zdravil v domačem okolju, uporaba predpisanih zdravil v bolnišnici, socialna izolacija, nedokazan uspeh zdravila, dejavnosti zdravstvenih delavcev za preprečevanje ali zdravljenje okužb zgornjih dihalnih poti, obravnava, osredotočena na otroka in starše. Identificirali smo tri kategorije: zdravstvena vzgoja, zdravljenje in ukrepi za izboljšanje zdravstvene obravnave, zdravstvena nega in oskrba.Diskusija in zaključek: Za kakovostno zdravstveno obravnavo otrok z okužbami zgornjih dihalnih poti je potreben pristop, ki je usmerjen k otroku in družini, je celosten ter varen. Ukrepi pri interdisciplinarni zdravstveni obravnavi otrok morajo temeljiti na znanstvenih dokazih. Poleg ustreznega zdravljenja in ukrepov je pomembno, da izvajamo tudi izobraževanje otrok in staršev.

show abstract

Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease

Cited by 7 publications

References 39 publications

Multiplex Platforms for the Identification of Respiratory Pathogens: Are They Useful in Pediatric Clinical Practice?

Multiplex Platforms for the Identification of Respiratory Pathogens: Are They Useful in Pediatric Clinical Practice?

New Insights into the Prevention of Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia Caused by Viruses

Ukrepi za obravnavo otroka z okužbo zgornjih dihalnih poti

Contact Info

Product

Resources

About