Molecular characterization of novel sequence type of carbapenem-resistant New Delhi metallo-β-lactamase-1-producing Klebsiella pneumoniae in the neonatal intensive care unit of an Indian hospital

Ahmad, Naved; Ali, Syed S.; Khan, Asad U.

doi:10.1016/j.ijantimicag.2018.12.005

Cited by 26 publications

(32 citation statements)

References 12 publications

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“…This result was agreed by previous report of Maruthupandy et al, 2019 , Rajivgandhi et al, 2019c , carbapenem resistant GNB was very dangerous. Recently, Ahmad et al (2018) reported that the carbapenems producing bacteria was shown to be more critical to destroy and kill during the infections time due to a lack of viable treatment choice.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, the antibiotics could not enter into the outer membrane of bacteria due to the production of porin mutations, and their carbapenamase production is increase the carbapenem resistance efficiency in bacteria ( Ece et al, 2018 ). Various classes of carbapenemases were emerged recently with different mechanisms of carbapenems hydrolysis activity including IMP, VIM, NDM, CMY and PDC beta-lactamases, OXA ( Ahmad et al, 2018 , Sharma et al, 2019 ). All of these genes were encoded by plasmid and pose a vigorous spread of carbapenem resistance nature ( Hamoud et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-carbapenamase activity of Camellia japonica essential oil against isolated carbapenem resistant klebsiella pneumoniae (MN396685)

Ramachandran

Rajivgandhi

Sevanan

et al. 2020

Saudi Journal of Biological Sciences

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-carbapenamase activity of Camellia japonica essential oil against isolated carbapenem resistant klebsiella pneumoniae (MN396685)

Ramachandran

Rajivgandhi

Sevanan

et al. 2020

Saudi Journal of Biological Sciences

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“…The detection of carbapenemases, such as OXA-48, IMP-4, VIM-1, NDM-1, and KPC-2, has been reported in CRKP isolated from newborn patients. [13][14][15][16][17] NDM-1-producing strains predominate in China. 8 KPC-2 and NDM-1 were identified in 57.1% and 42.9% of the isolated K. pneumoniae strains, respectively, while other carbapenemases were not.…”

Section: Discussionmentioning

confidence: 99%

<p>Epidemic Characteristics of Carbapenem-Resistant <em>Klebsiella pneumoniae</em> in the Pediatric Intensive Care Unit of Yanbian University Hospital, China</p>

Jin¹,

Shi²,

Jiang³

et al. 2020

IDR

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Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) pose a serious threat to clinical patient management and public health, as they are generally resistant to most antibiotics and cause infections with high mortality rates. Klebsiella pneumoniae ranks second among Enterobacteriaceae species that cause nosocomial infections. In this study, we investigated the epidemic characteristics of carbapenem-resistant K. pneumoniae (CRKP) in the pediatric intensive care unit (PICU) of Yanbian University Hospital. Materials and Methods: A total of 14 non-duplicate CRKP strains, collected from March 2015 to November 2019, were subjected to automated microbial identification and antimicrobial susceptibility tests using the Phoenix-100 ID/AST system. The strains were also subjected to genotypic resistance testing, polymerase chain reaction assays to detect genes encoding carbapenemases and other β-lactamases, multi-locus sequence typing (MLST), and pulsed-field gel electrophoresis (PFGE)-based homology analysis. Results: Two carbapenemase genes, KPC-2 and NDM-1 (in eight and six strains, respectively), were detected. MLST enabled the division of the strains into two sequence types, ST11 and ST1224 (containing eight and six strains, respectively). PFGE results classified the 14 strains into clonotypes AD , of which clonotypes A and B belonged to ST11, while clonotypes C and D belonged to ST1224. Conclusion: Our study reveals that epidemics of the KPC-2-ST11 and NDM-1-ST1224 strains occurred in the PICU of Yanbian University Hospital. Surveillance and strict implementation of prevention and control measures are crucial to prevent the occurrence and rapid spread of nosocomial infections.

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“…Livorsi et al [15] stated that 29,300 people in every 100,000 people in the United States have CRE infection, the detection rate of CRKP in ICU wards in some areas was as high as 72.6% [19]. The CRO strain has a strong ability to spread drug resistance, and its drug resistance mechanism is mainly the production of carbapenemase, abnormal expression of porin combined with ESBLs and AmpC, overexpression of efflux pumps, and conformational changes of the binding site which has mutated drug binding site gene [20,21].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Development and validation of a nomogram for predicting carbapenem-resistant organism infection and prognostic risk factors analysis in elderly hospitalized patients

Wang

Chen

et al. 2020

Preprint

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Background: With the extensive use of carbapenem-resistant organism (CRO), CRO infection is constantly detected clinically which has limited available drugs. There have many mechanisms of CRO resistance and rapid horizontal transmission, while the elderly with low resistance is more likely to acquire nosocomial infection. We aimed to screen elderly patients for nosocomial CRO infection and potential risk factors for prognosis. Methods: A total of 177 patients with CRO and carbapenem-sensitive organism (CSO) infection were included in this study. A least absolute shrinkage and selection operator (LASSO) analysis was used to select variables. The nomogram was constructed with multivariable logistic regression. The performance of the model was assessed by the receiver operating characteristic(ROC) curve, calibration, decision curve , and clinical influence curve. Using X-tile to stratify the prognosis risk, Kaplan-Meier curve for risk assessment. Results: Respiratory diseases, mechanical ventilation, indwelling urinary catheters , and APACHE II over 20 were selected as predictors of the CRO infection model. The model showed good discrimination and consistency in the training set and the validation set. The area under the ROC was 0.840 (95% CI: 0.773-0.900)in the training set and 0.822 (95% CI: 0.678-0.936) in the validation set. Decision analysis and influence curve showed that the model was clinically useful. Hepatobiliary diseases, indwelling urinary catheters, and hospital stays longer than 20 days were used as prognostic predictors. After analysis, the prognostic model demonstrated good discrimination of 0.817 (95% CI: 0.729-0.893) and consistency. Risk stratification showed the high-risk group had a poorer prognosis. Conclusion: Predicting clinically relevant risk factors for CRO nosocomial infection and prognosis in elderly patients. This may help the treatment of clinical drug-resistant infections.

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Molecular characterization of novel sequence type of carbapenem-resistant New Delhi metallo-β-lactamase-1-producing Klebsiella pneumoniae in the neonatal intensive care unit of an Indian hospital

Cited by 26 publications

References 12 publications

Anti-carbapenamase activity of Camellia japonica essential oil against isolated carbapenem resistant klebsiella pneumoniae (MN396685)

Anti-carbapenamase activity of Camellia japonica essential oil against isolated carbapenem resistant klebsiella pneumoniae (MN396685)

<p>Epidemic Characteristics of Carbapenem-Resistant <em>Klebsiella pneumoniae</em> in the Pediatric Intensive Care Unit of Yanbian University Hospital, China</p>

WITHDRAWN: Development and validation of a nomogram for predicting carbapenem-resistant organism infection and prognostic risk factors analysis in elderly hospitalized patients

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