Molecular cloning and expression analysis of neuregulin 1 (Nrg1) in the hypothalamus of Huoyan goose during different stages of the egg-laying cycle

Cao, Zhenzhen; Liu, Dawei; Liu, Mei; Gao, Ming; Chen, Zimo; Xing, Zhe; Zhang, Xiaoying; Yin, Yunhou; L, Xin

doi:10.1016/j.gene.2015.09.049

Cited by 2 publications

(3 citation statements)

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“…As regards the nervous system, the majority of previous studies concern distribution and functions of NRG1 in the central nervous system. This substance has been found in the brain of various animal species, including, among others, human [6], rat [7], mouse [8] and goose [9]. Based on previous studies, it is known that NRG1 in the central nervous system is involved in hypothalamic control of sexual maturation in rats [10], participates in mechanisms connected with oligodendrocytes survivability and differentiation in mice [11] and also regulates the higher nervous functions in rats (including memory and learning) [12].…”

Section: Introductionmentioning

confidence: 99%

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

Szymańska

Makowska

Całka

et al. 2020

IJMS

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The enteric nervous system (ENS), located in the wall of the gastrointestinal (GI) tract, is characterized by complex organization and a high degree of neurochemical diversity of neurons. One of the less known active neuronal substances found in the enteric neurons is neuregulin 1 (NRG1), a factor known to be involved in the assurance of normal development of the nervous system. During the study, made up using the double immunofluorescence technique, the presence of NRG1 in the ENS of the selected segment of porcine large intestine (caecum, ascending and descending colon) was observed in physiological conditions, as well as under the impact of low and high doses of bisphenol A (BPA) which is commonly used in the production of plastics. In control animals in all types of the enteric plexuses, the percentage of NRG1-positive neurons oscillated around 20% of all neurons. The administration of BPA caused an increase in the number of NRG1-positive neurons in all types of the enteric plexuses and in all segments of the large intestine studied. The most visible changes were noted in the inner submucous plexus of the ascending colon, where in animals treated with high doses of BPA, the percentage of NRG1-positive neurons amounted to above 45% of all neuronal cells. The mechanisms of observed changes are not entirely clear, but probably result from neurotoxic, neurodegenerative and/or proinflammatory activity of BPA and are protective and adaptive in nature.

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Section: Introductionmentioning

confidence: 99%

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

Szymańska

Makowska

Całka

et al. 2020

IJMS

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“…The hormone of E2 was identified as a crucial factor for promoting the synthesis/accumulation of plasma lipids, calcium, phosphorus and protein during sexual maturation. Moreover, the hormone of E2 could promote the rapid development of the fallopian tube and stimulate the synthesis/releasing of yolk precursors [ 25 ]. In this study, the concentration of E2 in serum of Wanxi White goose at the early laying period was significantly increased, which accelerated the plasma lipids, calcium, phosphorus and protein to be accumulated for satisfying the demands of the development of follicles and fallopian tubes.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the concentration of E2 in serum of Wanxi White goose at the early laying period was significantly increased, which accelerated the plasma lipids, calcium, phosphorus and protein to be accumulated for satisfying the demands of the development of follicles and fallopian tubes. Moreover, the concentration of E2 in serum was maintained at a high level to promote the synthesis and release of yolk precursors at peak laying [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Expression of Oocyte Vitellogenesis Receptor Was Regulated by C/EBPα in Developing Follicle of Wanxi White Goose

Chen

Han

et al. 2022

Animals

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Yolk precursor was synthesized under regulation of hormone secretion, while the mechanism of its incorporation into follicle is still unknown. The reproductive hormones, oocyte vitellogenesis receptor (OVR) expression at pre-, early-, peak- and ceased-laying period, and localization of Wanxi White goose were determined in this study. The results showed that the concentration of LH was lowest in serum at peak laying period compared to the other periods (p < 0.01). Moreover, the concentration of E2 was highest (p < 0.01) in serum at early laying period than that of other periods. Moreover, the gene expression level of OVR was highest at ceased laying period compared to other periods (p = 0.014) and was higher in developing follicles than other follicles (p < 0.01). The OVR was distributed in the granular cell layer and decreased with the maturation of follicles. Five transcription factors were predicted in the promoter of OVR, then were screened and verified by overexpression in granulosa cells. C/EBPα and MF3 significantly stimulated the expression of OVR. The combined overexpression of C/EBPα and OVR significantly stimulated the transportation of lipid from culture medium to cytoplasm. In conclusion, C/EBPα is the key transcription factor promoting OVR expression in goose follicle granulosa cells.

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Molecular cloning and expression analysis of neuregulin 1 (Nrg1) in the hypothalamus of Huoyan goose during different stages of the egg-laying cycle

Cited by 2 publications

References 39 publications

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

Expression of Oocyte Vitellogenesis Receptor Was Regulated by C/EBPα in Developing Follicle of Wanxi White Goose

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