2018
DOI: 10.1016/j.ecoenv.2018.08.083
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Molecular cloning, characterization, expression and enzyme activity of catalase from planarian Dugesia japonica in response to environmental pollutants

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Cited by 28 publications
(10 citation statements)
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“…Antioxidant responses can also be defined as the induction of antioxidant enzymes in the process mediated by the Keap1-Nrf2 system [ 39 ]. Among all the antioxidant enzymes, superoxide dismutase (SOD) is an antioxidant metal enzyme that can catalyze the disproportionation of superoxide anion radicals to generate oxygen and hydrogen peroxide; Catalase (CAT) is a resident enzyme of peroxisomes, decomposing hydrogen oxide into oxygen and water [ 40 ]; Glutathione peroxidase (GSH-Px) is an important peroxide decomposing enzyme widely present in the body [ 41 ]. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Antioxidant responses can also be defined as the induction of antioxidant enzymes in the process mediated by the Keap1-Nrf2 system [ 39 ]. Among all the antioxidant enzymes, superoxide dismutase (SOD) is an antioxidant metal enzyme that can catalyze the disproportionation of superoxide anion radicals to generate oxygen and hydrogen peroxide; Catalase (CAT) is a resident enzyme of peroxisomes, decomposing hydrogen oxide into oxygen and water [ 40 ]; Glutathione peroxidase (GSH-Px) is an important peroxide decomposing enzyme widely present in the body [ 41 ]. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…As mentioned before, HO • is chemically very reactive, so the first line of defense of parasitic flatworms is to prevent its production, the controlled reduction of H 2 O 2 to H 2 O being vital. The classic enzyme that carries out this reaction in aerobic organisms is catalase (CAT), which is absent in the genomes of parasitic flatworms [ 92 , 133 ] but is conserved in their free-living counterparts [ 134 ]. Hence, these parasites depend on enzymes glutathione peroxidase (GPx) and peroxiredoxin (Prx) in addition to the superoxide dismutase (SOD) necessary for O 2 •− scavenging.…”
Section: Adaptations Of Parasitic Flatworms To Changes In Oxygen Tensionmentioning
confidence: 99%
“…Colorimetric assays can be used to quantify the activity of hydrolases, oxidases, and other enzymes in homogenates of exposed planarians during neurodevelopment or in adulthood. The activity of oxidative stress related enzymes, such as catalase and superoxide dismutase, has been a popular molecular biomarker of toxicity in planarians (Zhang, Zhang, Yi, and Zhao, 2014, 2018). Additionally, the activity of neuronal enzymes, such as acetylcholinesterase (AChE), an important toxicological target (Russom, LaLone, Villeneuve, and Ankley, 2014), have been quantified (Hagstrom et al., 2018; Ireland, Zhang, et al., 2022; Li, 2008).…”
Section: Mechanistic Validation and Tools For High‐content Studiesmentioning
confidence: 99%