Molecular cloning, expression and appetite regulation function of adiponectin in Siberian sturgeon (Acipenser baerii)

Tang, Ni; Wang, Yongdong; Li, Yingzi; Liu, Yanling; Zhang, Shupeng; Xu, Shaoqi; Wang, Mei; Wang, Bin; Chen, Hu; Zhang, Xin; Zhou, Bo; Chen, Defang; Li, Zhiqiong

doi:10.1016/j.ijbiomac.2022.06.097

Cited by 16 publications

(4 citation statements)

References 40 publications

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“…PI3K can participate in POMC-, NPY-and CART-related appetite regulation [32,33]. Our previous studies have also con rmed that several adipocytokines play important roles in the regulation of sturgeon appetite [34]. Thus, the current results suggest that weaning may affect the appetite of sturgeon.…”

Section: Discussionsupporting

confidence: 72%

Exploration of appetite regulation in Yangtze sturgeon (Acipenser dabryanus) during weaning

Zhou

Wang

Chen

et al. 2023

Preprint

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Background Yangtze sturgeon is an endangered fish species. After weaning, Yangtze sturgeon fry refuse to consume any food, which causes theirlow survival rate during the artificial breeding period. Results The body length and body weight of failed weaning Yangtze sturgeons were significantly lower than those of successful weaning sturgeons. Since the brain is the center of appetite regulation, RNA-seq of the brain was employed to analyze the differentially expressed genes and their biological functions in successfully and unsuccessfully weaned fry. After that, 82,151 unigenes and 3222 DEGs were obtained. Based on the results of RNA-seq, appetite factors, including POMC, CART, NPYand AgRP, were cloned, and then a weaning experiment was designed to explore the changes in appetite after feeding a microcapsule diet (weaning group). The results showed that during the weaning period, the expression of CART was increased on the 1st and 3rd days but decreased onthe 5th, 6th, 8th and 10th days. The expression of AgRP was downregulated on the 1st and 3rd daysbut upregulated on the 5th, 6th, 8th and 10th days. Conclusions These findings indicate that appetite was suppressed in the early and middle periodsbut enhanced in the latter period of weaning and that CART may play animportant role in the appetite-suppressing effect.

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Section: Discussionsupporting

confidence: 72%

Exploration of appetite regulation in Yangtze sturgeon (Acipenser dabryanus) during weaning

Zhou

Wang

Chen

et al. 2023

Preprint

Self Cite

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“…PI3K can participate in pomc-, npyand cart-related appetite regulation [35,36]. Our previous studies have also con rmed that several adipocytokines play important roles in the regulation of sturgeon appetite [37]. Thus, the current results suggest that dietary transition may affect the appetite of sturgeon.…”

Section: Discussionsupporting

confidence: 64%

Exploration of appetite regulation in Yangtze sturgeon (Acipenser dabryanus) during dietary transition

Zhou,

Wang,

Chen

et al. 2023

Preprint

Self Cite

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Background The Yangtze sturgeon is an endangered fish species, and artificial breeding is an effective means of restoring its population. However, after transitioning to an artificial diet, several Yangtze sturgeons are reluctant to eat. Therefore, the objectivity of the current study was to investigate the response of appetite regulatory factors and analyze their expression throughout various stages of dietary transition. Results The body length and body weight of Yangtze sturgeons failed transiting diet were significantly lower than those succeed transiting diet sturgeons. Since the brain is the center of appetite regulation, RNA-seq of the brain was employed to analyze the differentially expressed genes and their biological functions in successfully and unsuccessfully transit diet fry. After that, 82,151 unigenes and 3222 DEGs were obtained. Based on the results of RNA-seq, appetite factors, including pomc, cart, npy and agrp, were cloned, and then a diet transiting experiment was designed to explore the changes in appetite after feeding a microcapsule diet (dietary transition group). The results showed that during the dietary transition period, the expression of cart was increased on the 1st and 3rd days but decreased on the 5th, 6th, 8th and 10th days. The expression of agrp was downregulated on the 1st and 3rd days but upregulated on the 5th, 6th, 8th and 10th days. Conclusions The results of this study can provide information for a better understanding of the appetite change during the dietary transition of Yangtze sturgeon and improve their survival rate after the dietary transition.

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“…Adiponectin is a circulating adipokine and well known for its insulin‐sensitizing effects 99 . Its role in appetite regulation is not yet fully unraveled as studies indicate both anorexigenic and orexigenic actions in the hypothalamus, possibly depending on blood glucose levels 100–104 . However, altered adiponectin levels in human eating disorders (e.g., anorexia nervosa and bulimia nervosa) point towards a direct link with appetite 105 .…”

Section: Glucocorticoids Appetite‐regulating Hormones and Eating Beha...mentioning

confidence: 99%

“… 99 Its role in appetite regulation is not yet fully unraveled as studies indicate both anorexigenic and orexigenic actions in the hypothalamus, possibly depending on blood glucose levels. 100 , 101 , 102 , 103 , 104 However, altered adiponectin levels in human eating disorders (e.g., anorexia nervosa and bulimia nervosa) point towards a direct link with appetite. 105 Moreover, adiponectin was recently found to decrease the activity of dopaminergic VTA neurons, suggesting a potential role in hedonic eating.…”

Section: Glucocorticoids Appetite‐regulating Hormones and Eating Beha...mentioning

confidence: 99%

Glucocorticoids, stress and eating: The mediating role of appetite‐regulating hormones

et al. 2022

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Disrupted hormonal appetite signaling plays a crucial role in obesity as it may lead to uncontrolled reward-related eating. Such disturbances can be induced not only by weight gain itself but also by glucocorticoid overexposure, for example, due to chronic stress, disease, or medication use. However, the exact pathways are just starting to be understood. Here, we present a conceptual framework of how glucocorticoid excess may impair hormonal appetite signaling and, consequently, eating control in the context of obesity. The evidence we present suggests that counteracting glucocorticoid excess can lead to improvements in appetite signaling and may therefore pose a crucial target for obesity prevention and treatment. In turn, targeting hormonal appetite signals may not only improve weight management and eating behavior but may also decrease detrimental effects of glucocorticoid excess on cardio-metabolic outcomes and mood. We conclude that gaining a better understanding of the relationship between glucocorticoid excess and circulating appetite signals will contribute greatly to improvements in personalized obesity prevention and treatment.

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Molecular cloning, expression and appetite regulation function of adiponectin in Siberian sturgeon (Acipenser baerii)

Cited by 16 publications

References 40 publications

Exploration of appetite regulation in Yangtze sturgeon (Acipenser dabryanus) during weaning

Exploration of appetite regulation in Yangtze sturgeon (Acipenser dabryanus) during weaning

Exploration of appetite regulation in Yangtze sturgeon (Acipenser dabryanus) during dietary transition

Glucocorticoids, stress and eating: The mediating role of appetite‐regulating hormones

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