Molecular contrast in optical coherence tomography using a pump-probe technique and a optical switch suppression technique

Yang, Changhuei; Rao, K. Divakar; Choma, Michael A.; Yazdanfar, Siavash; Rollins, Andrew M.; Izatt, Joseph A.

doi:10.1117/12.501007

Cited by 1 publication

(2 citation statements)

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“…Unlike the latter, the new optical switch suppression technique detects the conformational change of molecules before and after the pump suppression. There are only two types of pump suppression OCT contrast agents reported so far, which are bacteriorhodopsin (bR) [ 54 ] and phytochrome A [ 55 ]. Such kinds of molecules can reversibly change from one stable state to another through pump excitations.…”

Section: Pump Suppression Oct and Its Applicationsmentioning

confidence: 99%

“…Therefore, an OCT probe can scan at different stages to calculate the 3D distribution of molecular contrast agents. Yang et al, presented a pump suppression OCT system and demonstrated clear signals from bR solution samples during the scan [ 54 ]. In the original state, bR has an absorption peak in the javascript:void(0)red-green region of the spectrum.…”

Section: Pump Suppression Oct and Its Applicationsmentioning

confidence: 99%

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Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine

Wang

Gao

et al. 2022

IJMS

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The growing need to understand the molecular mechanisms of diseases has prompted the revolution in molecular imaging techniques along with nanomedicine development. Conventional optical coherence tomography (OCT) is a low-cost in vivo imaging modality that provides unique high spatial and temporal resolution anatomic images but little molecular information. However, given the widespread adoption of OCT in research and clinical practice, its robust molecular imaging extensions are strongly desired to combine with anatomical images. A range of relevant approaches has been reported already. In this article, we review the recent advances of molecular contrast OCT imaging techniques, the corresponding contrast agents, especially the nanoparticle-based ones, and their applications. We also summarize the properties, design criteria, merit, and demerit of those contrast agents. In the end, the prospects and challenges for further research and development in this field are outlined.

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Section: Pump Suppression Oct and Its Applicationsmentioning

confidence: 99%

Section: Pump Suppression Oct and Its Applicationsmentioning

confidence: 99%

Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine

Wang

Gao

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

Molecular contrast in optical coherence tomography using a pump-probe technique and a optical switch suppression technique

Abstract: Molecular contrast in optical coherence tomography using a pump-probe technique and a optical switch suppression technique," Proc. SPIE 5140, Optical Coherence Tomography and Coherence Techniques, (

Cited by 1 publication

References 4 publications

Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine

Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine

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