2004
DOI: 10.1053/j.gastro.2004.03.013
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Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome 1 ☆

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Cited by 666 publications
(712 citation statements)
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“…This biogenic amine is inactivated by the serotonin transporter protein (SERT), which belongs to the family of SLC 6A4 transporters (3). In one study, mRNA for SERT and tryptophan hydroxylase protein levels in rectal mucosa were found to be markedly decreased in rectal mucosa from patients with IBS, whether associated with diarrhea or constipation (4). This led to two intriguing hypotheses: first, that diarrhea resulted from the failure to inactivate serotonin and activation of receptors for serotonin that accelerate transit (e.g.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…This biogenic amine is inactivated by the serotonin transporter protein (SERT), which belongs to the family of SLC 6A4 transporters (3). In one study, mRNA for SERT and tryptophan hydroxylase protein levels in rectal mucosa were found to be markedly decreased in rectal mucosa from patients with IBS, whether associated with diarrhea or constipation (4). This led to two intriguing hypotheses: first, that diarrhea resulted from the failure to inactivate serotonin and activation of receptors for serotonin that accelerate transit (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…This led to two intriguing hypotheses: first, that diarrhea resulted from the failure to inactivate serotonin and activation of receptors for serotonin that accelerate transit (e.g. 5-HT 4 receptors); second, that constipation in IBS resulted from down-regulation of the receptor secondary to failure to inactivate the serotonin (4).Serotoninergic 5-HT 3 receptor antagonists are used to treat diarrhea-predominant IBS while 5-HT 4 receptor agonists are used to treat constipation-predominant IBS. However, it is unclear why only a subgroup of patients responds to these agents.…”
Section: Introductionmentioning
confidence: 99%
“…Recent reports have confirmed the relevance of the SERT function for the control of intestinal activity [30,31]. SERT expression and activity are affected in intestinal inflammation [10,[14][15][16] and inflammatory mediators have been shown to inhibit SERT function and expression in epithelial cells [12,13].…”
Section: Discussionmentioning
confidence: 81%
“…Recent results have demonstrated that SERT expression is downregulated and SERT activity is impaired in intestinal epithelial cells treated with pro-inflammatory factors [12,13], in animal models and human forms of intestinal inflammation [10,[14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, a reduction in SERT function impairs intracellular uptake and degradation, increasing availability of 5-HT within the mucosa. Coates et al [4] reported that mucosal 5-HT, tryptophan hydroxylase 1 messenger RNA (mRNA), SERT mRNA, and SERT immunoreactivity were all significantly reduced in rectal biopsy specimens of patients with UC, constipation-predominant IBS (IBS-C), and IBS-D compared with that of control groups. These data demonstrated that patients with UC and IBS shared similar molecular changes in serotonergic signaling mechanisms, and shared defects in 5-HT signaling which could plausibly alter motility, secretion, and sensation in the intestinal tract.…”
mentioning
confidence: 99%