Molecular Detection and Phylogenetic Analyses to Evaluate the Evolutionary Pattern of N, P, and G Gene Sequences of Some Recent Rabies Virus (RABV) Isolates from Elwadi- Elgedid Province in Egypt.

Abstract

INtroductIoNR abies is a world-widely distributing zoonotic disease with highly acute fatal encephalomyelitis in humans. The etiological agent is the rabies virus (RABV) which belongs to the genus Lyssavirus in the family Rhabdoviridae.It has a linear non-segmented single-stranded RNA of a negative sense of 12 kb length (MacLachlan et al., 2016). The genome has 58-nt of 3′ leader and 70-nt 5′ trailer. the genome composed of five genes Nucleoprotein (N) gene (nt 59 to 1483), phosphoprotein (P) gene (nt 1486 to 2475), matrix protein (M) gene (nt 2481 to 3283), gly-