Molecular discoveries in microbial DMSP synthesis

Carrión, Ornella; Zhu, Xiaoyu; Williams, Beth T.; Wang, Jinyan; Zhang, Xiaohua; Todd, Jonathan D.

doi:10.1016/bs.ampbs.2023.03.001

Cited by 5 publications

(3 citation statements)

References 118 publications

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“…Recently, Azizah and Pohnert 15 showed DMSOP accumulation in Pelagibaca bermudensis to be upregulated by oxidative stress and not increased by salinity, whereas DMSP levels, which were orders of magnitude higher than DMSOP, exhibited osmoregulatory patterns 15 . Thus, DMSOP may have different, for example, osmoregulatory or antioxidant, roles in different organisms that produce and/or accumulate it, as is the case for DMSP 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Above this, a potential role for DMSOP in osmoregulation was elucidated. The role of DMSOP in organisms that accumulate it will probably depend on its concentration, cellular location and catabolism in the host, like DMSP 2 . To be a major osmolyte, DMSOP would have to accumulate to high intracellular concentrations, which is rare in known DMSOP producers 14 , and the ~500-fold higher DMSP seawater concentration over DMSOP would largely favour the former as being imported for osmoregulation.…”

Section: Discussionmentioning

confidence: 99%

“…Microorganisms in Earth’s oceans and marine sediments produce >10 9 tons of the organosulfur compound dimethylsulfoniopropionate (DMSP) annually 1 , 2 for its role as an anti-stress, storage and signalling compound 3 – 7 . DMSP is a major carbon and sulfur source for marine microorganisms 8 , 9 via DMSP catabolic pathways that generate climate-active gases 10 , 11 , including methanethiol via bacterial DMSP demethylation 12 or dimethylsulfide (DMS) via DMSP cleavage in algae, bacteria and fungi 13 (Fig.…”

Section: Mainmentioning

confidence: 99%

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DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms

Carrión,

Li,

Peng

et al. 2023

Nat Microbiol

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Dimethylsulfoxonium propionate (DMSOP) is a recently identified and abundant marine organosulfur compound with roles in oxidative stress protection, global carbon and sulfur cycling and, as shown here, potentially in osmotolerance. Microbial DMSOP cleavage yields dimethyl sulfoxide, a ubiquitous marine metabolite, and acrylate, but the enzymes responsible, and their environmental importance, were unknown. Here we report DMSOP cleavage mechanisms in diverse heterotrophic bacteria, fungi and phototrophic algae not previously known to have this activity, and highlight the unappreciated importance of this process in marine sediment environments. These diverse organisms, including Roseobacter, SAR11 bacteria and Emiliania huxleyi, utilized their dimethylsulfoniopropionate lyase ‘Ddd’ or ‘Alma’ enzymes to cleave DMSOP via similar catalytic mechanisms to those for dimethylsulfoniopropionate. Given the annual teragram predictions for DMSOP production and its prevalence in marine sediments, our results highlight that DMSOP cleavage is likely a globally significant process influencing carbon and sulfur fluxes and ecological interactions.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Mainmentioning

confidence: 99%

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DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms

Carrión,

Li,

Peng

et al. 2023

Nat Microbiol

Self Cite

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Chromosome-scale genome assembly reveals insights into the evolution and ecology of the harmful algal bloom species Phaeocystis globosa Scherffel

Chen,

Xu,

Zhu

et al. 2024

iScience

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Elucidation of Spartina dimethylsulfoniopropionate synthesis genes enables engineering of stress tolerant plants

Payet,

Bilham,

Kabir

et al. 2024

Nat Commun

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The organosulfur compound dimethylsulfoniopropionate (DMSP) has key roles in stress protection, global carbon and sulfur cycling, chemotaxis, and is a major source of climate-active gases. Saltmarshes are global hotspots for DMSP cycling due to Spartina cordgrasses that produce exceptionally high concentrations of DMSP. Here, in Spartina anglica, we identify the plant genes that underpin high-level DMSP synthesis: methionine S-methyltransferase (MMT), S-methylmethionine decarboxylase (SDC) and DMSP-amine oxidase (DOX). Homologs of these enzymes are common in plants, but differences in expression and catalytic efficiency explain why S. anglica accumulates such high DMSP concentrations and other plants only accumulate low concentrations. Furthermore, DMSP accumulation in S. anglica is consistent with DMSP having a role in oxidative and osmotic stress protection. Importantly, administration of DMSP by root uptake or over-expression of Spartina DMSP synthesis genes confers plant tolerance to salinity and drought offering a route for future bioengineering for sustainable crop production.

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Molecular discoveries in microbial DMSP synthesis

Cited by 5 publications

References 118 publications

DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms

DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms

Chromosome-scale genome assembly reveals insights into the evolution and ecology of the harmful algal bloom species Phaeocystis globosa Scherffel

Elucidation of Spartina dimethylsulfoniopropionate synthesis genes enables engineering of stress tolerant plants

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