Molecular docking based screening of triterpenoids as potential G-quadruplex stabilizing ligands with anti-cancer activity

Sillapapongwarakorn, Sittichai; Yanarojana, Somchai; Pinthong, Darawan; Thithapandha, Amnuay; Ungwitayatorn, Jiraporn; Supavilai, Porntip

doi:10.6026/97320630013284

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…The most reactive oxygen species (ROS) include superoxide anion (O), hydroxyl radical (OH-), hydrogen peroxide radical (ROO-). The nitrogen derived free radicals are nitric oxide anion (NO-) and peroxynitrite anion (ONOO-) 53 . Most of the free radicals once produced are neutralized by cellular antioxidant defenses (enzymes and nonenzymatic molecules).…”

Section: Discussionmentioning

confidence: 99%

Ganoderma Lucidum - A Potential Medicinal Mushroom Against MDR Isolates from The Secondary Infections of Covid-19

Pushpa¹,

Senthilkumar²,

Ambikapathy³

et al. 2023

Int J Life Sci Pharm Res

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The severe acute respiratory syndrome produced by COVID-19 is a highly infectious and pathogenic viral infection. Many COVID-19 patients have secondary bacterial infections, which enhance disease and increase death, particularly when requiring invasive mechanical ventilation. One of the most important medicinal mushrooms, Ganoderma lucidum, has been used for food, feed, and medication since the dawn of humanity. The present investigation aims to discover the potential of the medicinal mushroom Ganoderma lucidum inhibited multidrug-resistant isolates from secondary infection of Covid-19 patients. Isolation and identification of urine samples from secondary infection of post-Covid-19 patients and evaluate the antibiotic sensitivity assay, as identification of bioactive compounds, anti-inflammatory and antioxidant activity from Ganoderma lucidum. Totally 6 clinical urine samples were collected from the age group 45 to 60; 3 were male, and 3 were female. In total, nine bacteria and 10 fungi were isolated and identified. As antibiotic sensitivity assays of ceftriaxone, fluoroquinolones, azithromycin and amphotericin, nystatin and fluconazole were performed by the disc diffusion method against bacteria and fungi, the zone of inhibition was maximal in Klebsiella pneumoniae and Fusarium oxysporum. The aqueous and ethanolic extracts of Ganoderma lucidum were analyzed for the bioactive compounds, viz., steroids, flavonoids, alkaloids and phenolic compounds. The effect of the anti-inflammatory activity of the aqueous extract was excellent. The activity of the DPPH assay was maximum in aqueous and ethanolic extracts of all concentrations (100 to 500 ml). Antibiotic resistance could probably rise due to the frequent prescription of broad-spectrum empiric antimicrobials to COVID-19 patients. Hence, Ganoderma lucidum can be exploited to prevent secondary infection in COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Ganoderma Lucidum - A Potential Medicinal Mushroom Against MDR Isolates from The Secondary Infections of Covid-19

Pushpa¹,

Senthilkumar²,

Ambikapathy³

et al. 2023

Int J Life Sci Pharm Res

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“…GA‐A has been documented to hold promising anticancer properties, embodying antiproliferative, antimetastatic, and antiangiogenic capacities with much lower side toxicity . Studies of Yang et al have suggested that GA‐A exerts antitumor activity against human breast cancer cell through regulating mitochondrial apoptosis, expression of cell‐cycle‐associated factors and proapoptotic signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Ganoderic acid A holds promising cytotoxicity on human glioblastoma mediated by incurring apoptosis and autophagy and inactivating PI3K/AKT signaling pathway

Cheng

Xie

2019

J Biochem & Molecular Tox

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Ganoderic acid A (GA-A), recognized as a lanostanetriterpene isolated fromGanoderma lucidum, demonstrates an efficient antitumor activity in multiple cancers.To date, it is unclear whether and how GA-A functions on human glioblastoma (GBM).To unravel the functional significance of GA-A on human glioblastoma (GBM), the cell-counting kit-8 and transwell assays were used to detect proliferation, migration, and invasion of human GBM cell after GA-A treatment. Then, we utilized the flow cytometry and western blot to further evaluate the effect of GA-A on GBM cell.Further, activities of autophagy and PI3K/AKT signaling were assessed by Western blot assay. We found that GA-A significantly inhibited proliferation, migration, and invasion of GBM cell. Additionally, GA-A markedly triggered cell apoptosis, which incarnated an elevation trend in apoptotic percentage, simultaneously, an increased level of proapoptosis protein (Bax and active caspase-3) and a decreased level of antiapoptosis protein (Bcl-2), induced by GA-A treatment. Meanwhile, levels of two well-known autophagy markers (beclin 1 and LC3 II) increased while another autophagic substrate (P-62) was reduced. Moreover, the expressions levels of phosphorylated AKT, mTOR, p-P70S6K, and cyclin D1 in the PI3K/AKT pathway were significantly reduced, which revealed GA-A repressed the activation of PI3K/AKT signaling pathway. Collectively, these results indicate that GA-A may encourage U251 cell growth and invasion/migration inhibition, apoptosis, and autophagy through the inactivation of PI3K/AKT signaling pathway in human GBM. Hence, GA-A may be a potent antitumorigenic agent for human GBM in future clinical practice.

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“…The function of the zinc finger 439 protein remains unknown, but it is suggested to be involved in the regulation of gene transcription. Moreover, lucidenic acids may act as potential quadruplex stabilizing ligands and promising inhibitors of Bcl-2 [ 74 , 75 ], which is a well-known apoptosis suppressor.…”

Section: Potential Pharmacological Effects Of Lucidenic Acidsmentioning

confidence: 99%

A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids

et al. 2023

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Ganoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G. lucidum are primarily attributed to its polysaccharides and triterpenoids. Ganoderic and lucidenic acids are the two major triterpenoids groups in G. lucidum. Despite the discovery of 22 types of lucidenic acids, research on lucidenic acids is significantly less extensive compared to that on ganoderic acid. To the best of our knowledge, for the first time, in this review, we aimed to summarize the sources, contents, chemical structures, and pharmacological effects, including anti-cancer, anti-inflammatory, antioxidant, anti-viral, neuroprotective, anti-hyperlipidemic, anti-hypercholesterolemic, and anti-diabetic properties, of lucidenic acids. Studies on lucidenic acids are still preliminary and have several limitations. Therefore, more in-depth studies with optimal designs are essential for the development of lucidenic acids as medicines, functional foods, and nutraceuticals.

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Molecular docking based screening of triterpenoids as potential G-quadruplex stabilizing ligands with anti-cancer activity

Cited by 10 publications

References 26 publications

Ganoderma Lucidum - A Potential Medicinal Mushroom Against MDR Isolates from The Secondary Infections of Covid-19

Ganoderma Lucidum - A Potential Medicinal Mushroom Against MDR Isolates from The Secondary Infections of Covid-19

Ganoderic acid A holds promising cytotoxicity on human glioblastoma mediated by incurring apoptosis and autophagy and inactivating PI3K/AKT signaling pathway

A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids

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