Molecular dynamics in the supercooled liquid and glassy states of bezafibrate and binary mixture of fenofibrate

Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles

“…Two main relaxation processes were detected, a dominating process associated with the dynamic glass transition, a designated α-process (visible in the frequency window above ~ −30 °C) and a secondary γ relaxation (emerging at temperatures as low as −110 °C), attributed to the rotation of the C 6 H 4 O 3 (CH 3 )C=O2-O1(CH 3 ) 2 group ( Scheme 1 ), relative to the dihedral angle between two aromatic groups; [ 22 , 70 ] the intramolecular nature of this process was demonstrated according to its low activation energy (close to 30 kJ mol −1 ) and pressure insensitivity by Szklarz et al [ 71 ]. The here-obtained parameters ( Table S2 ) for both α relaxation and the γ-process are similar to the ones reported in the literature [ 22 , 71 ].…”

“…The here-obtained parameters ( Table S2 ) for both α relaxation and the γ-process are similar to the ones reported in the literature [ 22 , 71 ]. A third process is required in the fitting analysis, partially overlapping with the α peak, whose features allow for the identification of it as a Johari–Goldstein (JG) process (β JG ), as previously suggested in the literature, [ 70 ] being pressure-sensitive as a characteristic of a process with an intermolecular nature [ 71 ]. The detailed analysis for the bulk FNB is shown in the Supplementary Materials section Dielectric analysis of amorphous bulk FNB.…”

“…The following supporting information can be downloaded at https:// www.mdpi.com/article/10.3390/pharmaceutics15061624/s1. References [22,23,70,71,79,[85][86][87][88][89] are cited in the Supplementary Materials.…”

“…The following supporting information can be downloaded at . References [ 22 , 23 , 70 , 71 , 79 , 85 , 86 , 87 , 88 , 89 ] are cited in the Supplementary Materials.…”