Molecular dynamics study on the adsorption and release of doxorubicin by chitosan-decorated graphene

Shen, Jia-Wei; Li, Jiachen; Dai, Junhao; Zhou, Mengdi; Ren, Hao; Zhang, Li; Hu, Quan; Kong, Zhe; Liang, Lijun

doi:10.1016/j.carbpol.2020.116809

Cited by 29 publications

(13 citation statements)

References 41 publications

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“…This bioactive polymer 65,66 has the potential to influence the adsorption and desorption of drug molecules on the graphene family's surface and maintain their stability. 67,68 Besides, divalent cations, like chitosan, can facilitate DNA linkage on the graphene oxide surface. All these features indicate that chitosan can improve the efficiency of the gene/ drug delivery systems based on graphene for curing cancer.…”

Section: Graphene-based Materials Functionalization For Cancer Therapymentioning

confidence: 99%

Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications

et al. 2023

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Section: Graphene-based Materials Functionalization For Cancer Therapymentioning

confidence: 99%

Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications

et al. 2023

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“…Therefore, at mild acidic pH of the tumor microenvironment, protonation of CS occurs and leads to the release of DOX from nanocarriers. 262 Graphene oxide (GO) is a derivative of graphite or graphene and has a two‐dimensional plate‐like structure. The GO sheets have both sides and due to their large surface area, they are considered as promising structures for the delivery of antitumor drugs.…”

Section: Nanostructures Of Chitosan‐doxorubicinmentioning

confidence: 99%

Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

Ashrafizadeh

Hushmandi

Mirzaei

et al. 2022

Bioengineering & Transla Med

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Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS‐based nanoparticles (CS‐NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS‐NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P‐glycoprotein (P‐gp) to reverse drug resistance. These nanoarchitectures can provide co‐delivery of DOX with antitumor agents such as curcumin and cisplatin to induce synergistic cancer therapy. Furthermore, co‐loading of DOX with siRNA, shRNA, and miRNA can suppress tumor progression and provide chemosensitivity. Various nanostructures, including lipid‐, carbon‐, polymeric‐ and metal‐based nanoparticles, are modifiable with CS for DOX delivery, while functionalization of CS‐NPs with ligands such as hyaluronic acid promotes selectivity toward tumor cells and prevents DOX resistance. The CS‐NPs demonstrate high encapsulation efficiency and due to protonation of amine groups of CS, pH‐sensitive release of DOX can occur. Furthermore, redox‐ and light‐responsive CS‐NPs have been prepared for DOX delivery in cancer treatment. Leveraging these characteristics and in view of the biocompatibility of CS‐NPs, we expect to soon see significant progress towards clinical translation.

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“…Chi-decorated GO will be a natural cationic polysaccharide to improve compatibility [ 208 ]. The absorb and release of DOX which can be controlled by Chi-decorated graphene by adjusting the pH of the solution to the protonation state of chitosan and the concentration and aggregation of DOX and chitosan molecules [ 209 ]. DOX molecules can bind to bare graphene surface that is not attached to Chi and also be adsorbed on top of the chitosan chain.…”

Section: Drug Delivery Applicationmentioning

confidence: 99%

Recent Development of Nano-Carbon Material in Pharmaceutical Application: A Review

et al. 2022

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Carbon nanomaterials have attracted researchers in pharmaceutical applications due to their outstanding properties and flexible dimensional structures. Carbon nanomaterials (CNMs) have electrical properties, high thermal surface area, and high cellular internalization, making them suitable for drug and gene delivery, antioxidants, bioimaging, biosensing, and tissue engineering applications. There are various types of carbon nanomaterials including graphene, carbon nanotubes, fullerenes, nanodiamond, quantum dots and many more that have interesting applications in the future. The functionalization of the carbon nanomaterial surface could modify its chemical and physical properties, as well as improve drug loading capacity, biocompatibility, suppress immune response and have the ability to direct drug delivery to the targeted site. Carbon nanomaterials could also be fabricated into composites with proteins and drugs to reduce toxicity and increase effectiveness in the pharmaceutical field. Thus, carbon nanomaterials are very effective for applications in pharmaceutical or biomedical systems. This review will demonstrate the extraordinary properties of nanocarbon materials that can be used in pharmaceutical applications.

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Molecular dynamics study on the adsorption and release of doxorubicin by chitosan-decorated graphene

Cited by 29 publications

References 41 publications

Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications

Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications

Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

Recent Development of Nano-Carbon Material in Pharmaceutical Application: A Review

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