“…To the best of our knowledge, only seven small-scale HPV prevalence studies performed on a total of 129 histologically confirmed CW tissue samples have been published in peerreviewed literature to date (Supplementary Table 1) (Gross et al, 1982;Chen et al, 1993;Egawa, 1994;Lei et al, 2009;Sun et al, 2010;de Koning et al, 2011;Šterbenc et al, 2017), with HPV2/27/57 and HPV1 being the most prevalent HPVs detected, but with extremely variable detection rates obtained in different studies (0-83.5 and 0-46.7% prevalence, respectively). Similarly, detection rates of multiple HPVs (the presence of more than one HPV type within one lesion) were tremendously variable (0-88.9%), prompting the development of tools for assessment of the most probable lesion-causative HPV among those detected within a particular CW (Šterbenc et al, 2017).…”