Molecular Epidemiology

Negra, Laguna; Rosa, Elizabeth Salbé Travassos da; Simith, Darlene B.; Pereira, Sandro F. F.; Elkhoury, Mauro R.; Santos, Elizabeth Davi; Lavocat, Marília; Marques, A. A. R; Kohl, Vânia A.; Bonvicino, Cibele Rodrigues; Lemos, Elba Regina Sampaio de

doi:10.1128/9781555816728.ch8

Cited by 40 publications

(1 citation statement)

References 190 publications

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“…MLST utilizes nucleotide sequencing to detect variations in fragments of 5 to 10 housekeeping genes, with a single point mutation difference between genes considered to be a new allele. 67 Previously conducted by the PCR method, MLST is now routinely performed by WGS, with the examination of the various loci as the standard methodology. 68 , 69 The MLST data can be shared and tracked across laboratories via several websites, like http://pubmlst.org and https://bigsdb.pasteur.fr/ .…”

Section: Step 3 Review Local Regional and Geographical Epidemiology O...mentioning

confidence: 99%

#AMRrounds: a systematic educational approach for navigating bench to bedside antimicrobial resistance

Liu,

Prinzi,

Borjan

et al. 2023

JAC-Antimicrobial Resistance

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Antimicrobial resistance (AMR) continues to serve as a major global health crisis. Clinicians practising in this modern era are faced with ongoing challenges in the therapeutic management of patients suffering from antimicrobial-resistant infections. A strong educational understanding and synergistic application of clinical microbiology, infectious disease and pharmacological concepts can assist the adventuring clinician in the navigation of such cases. Important items include mobilizing laboratory testing for pathogen identification and susceptibility data, harnessing an understanding of intrinsic pathogen resistance, acknowledging epidemiological resistance trends, recognizing acquired AMR mechanisms, and consolidating these considerations when constructing an ideal pharmacological plan. In this article, we outline a novel framework by which to systematically approach clinical AMR, encourage AMR-related education and optimize therapeutic decision-making in AMR-related illnesses.

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Section: Step 3 Review Local Regional and Geographical Epidemiology O...mentioning

confidence: 99%