2019
DOI: 10.17106/jbr.33.28
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Molecular events regulating the pathogenesis of intracranial aneurysms: Special insight on hemodynamics and chronic inflammation

Abstract: Intracranial aneurysm (IA) can cause a lethal subarachnoid hemorrhage after rupture. Thereby, the correct understanding of the pathogenesis of the disease is essential to develop a novel therapeutic strategy to prevent progression. The accumulating evidence from simulation of hemodynamics targeting human cases has implied the role of hemodynamic force in IAs. In another point of view, experimental evidence mainly from animal studies has clarified the crucial role of macrophage-mediated long lastinginflammation… Show more

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