Molecular findings in maxillofacial bone tumours and its diagnostic value

Cleven, Arjen H.G.; Schreuder, Willem H.; Groen, Eline; Kroon, Herman M.; Baumhoer, Daniel

doi:10.1007/s00428-019-02726-2

Cited by 21 publications

(19 citation statements)

References 49 publications

(58 reference statements)

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“…These tumours represent 0.1% of all tumours of the head and neck region and may occur in the nasal cavity, maxilla, and mandible in addition to the larynx. In regard to the larynx, ChS accounts for 1% of all laryngeal neoplasms[ 2 , 3 ]. Although these tumours rarely occur in the larynx, they have the second highest frequency after tumours originating from epithelial tissue, squamous cell carcinoma and adenocarcinoma[ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Low-grade chondrosarcoma of the larynx: A case report

Vučković¹,

Klisić²,

Filipović³

et al. 2021

WJCC

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BACKGROUND Chondrosarcomas of the larynx are malignant tumours that most commonly originate from the hyaline cartilage. Chondrosarcoma of the larynx, the most common type of low-grade tumour, accounts for 1% of all laryngeal neoplasms. CASE SUMMARY We present the case of a 60-year-old female patient who developed progressive hoarseness and shortness of breath over a 2-mo period. The patient had undergone resection of a laryngeal tumour 14 years before the aforementioned symptoms occurred, and histopathological analysis indicated that it was a chondroma. During the assessment of the patient, a submucosal, oval-shaped tumour was detected that was predominantly located on the left side of the larynx and was approximately 6 cm in size. The decision to perform left partial vertical laryngectomy was made. A pathohistological diagnosis of low-grade chondrosarcoma was made. Considering the results of pathohistological analysis and the positive margins of the resection, a total laryngectomy was performed. During the 12-mo follow-up, no local relapse or regional or distant metastases was detected. CONCLUSION Chondrosarcoma of the larynx must be considered in the differential diagnosis of laryngeal submucosal tumours. It is crucial to carefully sample of tumour tissue, differentiate chondroma and chondrosarcoma, and consider the possibility of malignant changes from chondroma to chondrosarcoma.

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Section: Introductionmentioning

confidence: 99%

Low-grade chondrosarcoma of the larynx: A case report

Vučković¹,

Klisić²,

Filipović³

et al. 2021

WJCC

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“…The increase in the activity of GSα in osteoblast progenitor cells and osteoclasts is stimulated by the amplified production of interleukin-6 stromal cells [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Monostotic fibrous dysplasia (MFD) is around 10 times more common than polyostotic fibrous dysplasia (PFD) and is frequently unilateral [3,4]. The lack of stable bone matrix formation can manifest in a multitude of ways, involving facial distortion and asymmetry [5][6][7]. In the jaws, tooth movement, occlusion problems, pain, paresthesia, and interference with dental eruption can be observed [3].…”

Section: Introductionmentioning

confidence: 99%

Monostotic Fibrous Dysplasia of the Mandible in a 9-Year-Old Male Patient Treated with a Conservative Surgical Treatment: A Case Report and 15-Year Follow-Up

Berbéri

Aoun

Khalaf

et al. 2021

Case Reports in Dentistry

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Fibrous dysplasia is a developmental disorder of the bone that originates from a genetic defect disturbing the osteogenesis leading to the replacement of normal bone with the excess proliferation of fibrous tissue. It can be associated with hyperpigmentation of the skin and endocrine disorders. Fibrous dysplasia can manifest in a monostotic form affecting one bone or in a polyostotic form involving several bones. Approximately 30% of monostotic forms are observed in the maxilla and the mandible. It frequently appears in the posterior region and is usually unilateral. It is found in teenagers and could become static after adulthood. Patients can present with swelling, facial asymmetry, pain, or numbness on the affected side. Treatment modalities vary between conservative surgical treatment, radical surgical approach, and medical treatment based on bisphosphonates. Here, we present a case of a monostotic form of fibrous dysplasia affecting the posterior left region of the mandible in a 9-year-old male complaining of gradually increased swelling on the left mandibular side of one-year duration. The diagnosis of fibrous dysplasia is established based on clinical, radiographical, and histopathological features. Conservative surgery is implemented with surgical shaving and reencountering of the bone excess to reduce the facial asymmetry. Recurrence is reported 10 years later and is also treated with a localized osteoplasty and remodeling of the bone contours. Five years later, the lesion remains stable. In conclusion, a conservative approach should be adopted as the first line of treatment for young patients suffering from monostotic fibrous dysplasia.

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“…The genetic etiology includes activating mutations in the MAP-kinase signaling pathway, KRAS , and FGFR1 mutations. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: A rare case report

Pattnaik

Rajguru

Pattanaik

et al. 2020

J Family Med Prim Care

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Peripheral giant cell granuloma (PGCG) known as “giant cell epulis” is a benign, reactive exophytic gingival lesion that accounts for less than 10% of all gingival lesions. PGCG affects females more than males with middle age predilection. Till now the etiology of PGCG remains unclear but various factors that can cause PGCG include poor oral hygiene, food impaction, following an extraction, dry mouth, hormonal disturbance, and hyperparathyroidism. The reported recurrence rate of the lesion is 5.0%–70.6%. The present case report describes the rare case of PGCG with primary hyperparathyroidism in a male patient with a history of swelling in the mandibular anterior region.

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Molecular findings in maxillofacial bone tumours and its diagnostic value

Cited by 21 publications

References 49 publications

Low-grade chondrosarcoma of the larynx: A case report

Low-grade chondrosarcoma of the larynx: A case report

Monostotic Fibrous Dysplasia of the Mandible in a 9-Year-Old Male Patient Treated with a Conservative Surgical Treatment: A Case Report and 15-Year Follow-Up

Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: A rare case report

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