Molecular Fluorescent Probes for Liver Tumor Imaging

Liu, Qian; Huang, Jia; He, Longwei; Yuan, Lin; Cheng, Dan

doi:10.1002/asia.202200091

Cited by 12 publications

(8 citation statements)

References 75 publications

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“…Due to the excellent performance of this probe, we proposed that it might also be used for precise image-guided resection of tumors. Image-guided resection has attracted much attention in the clinical study to achieve accurate identification of tumors and normal tissues. − Thus, we finally carried out the research. The probe’s photoacoustic imaging capability is used to locate the tumor and evaluate the size of the tumor; fluorescence image-guided resection is then performed.…”

Section: Resultsmentioning

confidence: 99%

γ-Glutamyltransferase-Activatable Fluoro-Photoacoustic Reporter for Highly Sensitive Diagnosis of Acute Liver Injury and Tumor

et al. 2023

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γ-Glutamyltransferase (GGT) has been recognized as an important clinical biomarker that is closely related to many diseases. Visualizing the GGT fluctuation facilitates early diseaserelated diagnosis and therapy. Herein, an activated probe (NIR-GGT) for the imaging of GGT activity was prepared. The probe consists of a stable NIR fluorophore with the tunable amino group decorated with the γ-glutamate group as a GGT-sensing unit linked by a self-elimination group. NIR-GGT can sensitively recognize GGT and cause a strong turn-on fluorescent and photoacoustic signal. The up-regulation of the GGT expression in acetaminophen-induced acute liver injury was imaged using NIR-GGT. The probe can track changes in the GGT level in the early stages of drug-induced acute liver injury (DIALI) and its remedy process by fluorescent and photoacoustic dual-modality imaging with a high temporal−spatial resolution. NIR-GGT can also be used to differentiate between tumor and para-carcinowa tissues in vivo. The probe may be a potential tool for the diagnosis of early-stage DIALI and accurate tumor resection in the clinical field.

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Section: Resultsmentioning

confidence: 99%

γ-Glutamyltransferase-Activatable Fluoro-Photoacoustic Reporter for Highly Sensitive Diagnosis of Acute Liver Injury and Tumor

et al. 2023

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“…The transfected B7-H3 CAR T-cells were intravenously injected into a mouse model of human osteosarcoma (the mice were injected with transfected MG63.3 human osteosarcoma cells), and their biodistribution, tumor homing, and therapeutic efficacy were evaluated by delayed bioluminescence imaging. Skovgard et al [37] bioavailable, and specific substrate for the luciferase, and (iii) stable expression of the luciferase in ACT immune cells [39]. Bioluminescence imaging probes have been mainly used for in vivo visualization of ACT immune cells in preclinical research because of their limited imaging depth and complicated preparation.…”

Section: Bioluminescence Imaging Probesmentioning

confidence: 99%

“…The above studies demonstrated the significant role of bioluminescence imaging probes in the in vivo visualization of ACT immune cells and provided directions for the development of new bioluminescence imaging probes. The following should be considered in the development of new bioluminescence imaging probes for in vivo visualization of ACT immune cells [38]: (i) the development of a highly active and non‐toxic luciferase, (ii) the development of a highly water‐soluble, bioavailable, and specific substrate for the luciferase, and (iii) stable expression of the luciferase in ACT immune cells [39]. Bioluminescence imaging probes have been mainly used for in vivo visualization of ACT immune cells in preclinical research because of their limited imaging depth and complicated preparation.…”

Section: Classifications Of Optical Imaging Probesmentioning

confidence: 99%

Optical imaging of in vivo adoptive T‐cell therapy: State of the art and challenges

Gao

et al. 2023

iRADIOLOGY

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Adoptive T‐cell therapy (ACT), which is an important type of live cell therapy, has achieved unprecedented success in treating hematological malignancies. Recent studies have shown that ACT is also a promising treatment for solid tumors. Visualizing the in vivo fates (distribution, homing, infiltration, proliferation, and exhaustion) of the immune cells used for ACT (ACT immune cells) is of great importance to promote basic research and clinical translation of ACT. Optical imaging techniques, including bioluminescence, fluorescence, and photoacoustic imaging, have the advantages of high sensitivity, high spatiotemporal resolution, minimal exposure to harmful radiation, and simple instrumentation. Recently, various types of optical imaging probes, including bioluminescence, fluorescence, and photoacoustic imaging probes, have been used to visualize ACT immune cells in vivo and evaluate the molecular mechanism, efficacy, and side effects of ACT. In this review, the optical imaging probes and labeling methods that have been used for in vivo visualization of ACT immune cells are summarized, and the opportunities and challenges of using optical imaging to visualize ACT immune cells in vivo are discussed.

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“…The liver is the body's largest and most important metabolic organ, which undertakes most of the body's toxin discharge. There are many possible causes of liver cancer, such as obesity, diabetes, fatty liver and so on [ 218 ]. Liver cancer is a very serious public health problem with an increasing incidence every year, with 841,000 incident cases and 782,000 mortalities worldwide in 2018 alone [ 219 ].…”

Section: Aie-pss For Different Cancers Treatmentmentioning

confidence: 99%

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

et al. 2022

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Cancer remains a serious threat to human health owing to the lack of effective treatments. Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment that consists of three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone to aggregation-caused quenching (ACQ), leading to reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due to their distorted structure, suppress the strong molecular interactions, making them more photosensitive in the aggregated state instead. Activated by light, they can efficiently produce ROS and induce cell death. PS is one of the core factors of efficient PDT, so proceeding from the design and preparation of AIE-PSs, including how to manipulate the electron donor (D) and receptor (A) in the PSs configuration, introduce heavy atoms or metal complexes, design of Type I AIE-PSs, polymerization-enhanced photosensitization and nano-engineering approaches. Then, the preclinical experiments of AIE-PSs in treating different types of tumors, such as ovarian cancer, cervical cancer, lung cancer, breast cancer, and its great potential clinical applications are discussed. In addition, some perspectives on the further development of AIE-PSs are presented. This review hopes to stimulate the interest of researchers in different fields such as chemistry, materials science, biology, and medicine, and promote the clinical translation of AIE-PSs. Graphical Abstract

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Molecular Fluorescent Probes for Liver Tumor Imaging

Cited by 12 publications

References 75 publications

γ-Glutamyltransferase-Activatable Fluoro-Photoacoustic Reporter for Highly Sensitive Diagnosis of Acute Liver Injury and Tumor

γ-Glutamyltransferase-Activatable Fluoro-Photoacoustic Reporter for Highly Sensitive Diagnosis of Acute Liver Injury and Tumor

Optical imaging of in vivo adoptive T‐cell therapy: State of the art and challenges

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

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