Molecular insights into the transgenerational inheritance of stress memory

Zhang, Qian; Tian, Ye

doi:10.1016/j.jgg.2021.11.015

Cited by 21 publications

(8 citation statements)

References 87 publications

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“…UPR mt is also required for the healthspan induced by neuronal-specific epigenetic modifications, which participate in mitochondrial gene expression in C. elegans (Yuan et al, 2020a). More importantly, the neuronal mitochondrial stress can also communicate to the germ cells, which promotes the maternal inheritance of elevated levels of mtDNA, thereby passing down a "stress memory of the UPR mt activation" to offspring, enabling descendants with a greater tolerance to stress and a longer lifespan (Zhang and Tian, 2022;Zhang et al, 2021f). Thus, the ability of the nervous system to perceive the stress cues and propagate systemic signals to induce metabolic adaptations in peripheral tissues may result in UPR mt activation and increased longevity of the entire animal.…”

Section: Mitochondrial Ros Signalingmentioning

confidence: 99%

The landscape of aging

Cai

Song

et al. 2022

Sci. China Life Sci.

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200

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Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels.

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Section: Mitochondrial Ros Signalingmentioning

confidence: 99%

The landscape of aging

Cai

Song

et al. 2022

Sci. China Life Sci.

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200

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“…Thus, Birch et al (2020) expect that planarians and nematodes would have more widespread epigenetic inheritance than Cambrian' latecomers, and, therefore, be less likely to be conscious. Nevertheless, genes erasing epigenetic stress methylation states, such as DDM1 or Lsh, are conserved from plants to mammals (Iwasaki & Paszkowski, 2014;Tao et al, 2011), and transgenerational epigenetic inheritance in vertebrates, specially when it is mediated by small non coding RNAs (i.e., siRNAs, miRNAs, piRNAs, tsR-NAs, rRNAs, and circRNA), is only beginning to be unraveled (Bowers & Yehuda, 2016;Hime et al, 2021;Yehuda & Lehrner, 2018;Zhang & Tian, 2022). Therefore, regardless of Birch et al (2020) claim, the augmented prevalence of epigenetic inheritance in animals without UAL (and thus, without consciousness) remains conjectural.…”

Section: Evidence Of Registration Of Self-other In C Elegansmentioning

confidence: 99%

The Conscious Nematode: Exploring Hallmarks of Minimal Phenomenal Consciousness in Caenorhabditis Elegans

Becerra,

Calixto,

Orio

2023

Int. j. psychol. res.

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While subcellular components of cognition and affectivity that involve the interaction between experience, environment, and physiology —such as learning, trauma, or emotion— are being identified, the physical mechanisms of phenomenal consciousness remain more elusive. We are interested in exploring whether ancient, simpler organisms such as nematodes have minimal consciousness. Is there something that feels like to be a worm? Or are worms blind machines? ‘Simpler’ models allow us to simultaneouslyextract data from multiple levels such as slow and fast neural dynamics, structural connectivity, molecular dynamics, behavior, decision making, etc.,and thus, to test predictions of the current frameworks in dispute. In the present critical review, we summarize the current models of consciousness in order to reassess in light of the new evidence whether Caenorhabditiselegans, a nematode with a nervous system composed of 302 neurons, has minimal consciousness. We also suggest empirical paths to further advance consciousness research using C. elegans.

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“…Our previous study found that Wnt/EGL-20 is a mitokine signal not only required but also sufficient to propagate UPR mt signaling from neurons to peripheral tissues (Berendzen et al, 2016;Zhang and Tian, 2022;Zhang et al, 2018bZhang et al, , 2021. Furthermore, neuronally overexpressed Wnt ligand EGL-20 is sufficient to activate cell-non-autonomous UPR mt in a retromer complexand serotonin-dependent manner and induces lifespan extension in C. elegans (Zhang et al, 2018b).…”

Section: Introductionmentioning

confidence: 99%

Molecular insights into the transgenerational inheritance of stress memory

Cited by 21 publications

References 87 publications

The landscape of aging

The landscape of aging

The Conscious Nematode: Exploring Hallmarks of Minimal Phenomenal Consciousness in Caenorhabditis Elegans

Protein disulfide isomerase PDI-6 regulates Wnt secretion to coordinate inter-tissue UPRmt activation and lifespan extension in C. elegans

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