2023
DOI: 10.1016/j.ejphar.2023.175867
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Molecular interplay between EIF4 family and circular RNAs in cancer: Mechanisms and therapeutics

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Cited by 3 publications
(1 citation statement)
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“…It has been identified as an inhibitor of eukaryotic initiation factor 4A (eIF4A), one of the eukaryotic translation initiation factors, and is noted for its high specificity and tolerability in animal models [8]. The overactivity of translation initiation factors is closely linked to translation dysregulation, a condition that is strongly associated with excessive cell proliferation, angiogenesis, survival, and altered energetics in tumors [9,10]. Consequently, silvestrol has demonstrated the capability to inhibit the growth of numerous cancer cell lines at low nanomolar concentrations [11][12][13][14], especially targeting mRNAs with highly structured 5′UTR that are heavily reliant on eIF4A for translation [15].…”
Section: Introductionmentioning
confidence: 99%
“…It has been identified as an inhibitor of eukaryotic initiation factor 4A (eIF4A), one of the eukaryotic translation initiation factors, and is noted for its high specificity and tolerability in animal models [8]. The overactivity of translation initiation factors is closely linked to translation dysregulation, a condition that is strongly associated with excessive cell proliferation, angiogenesis, survival, and altered energetics in tumors [9,10]. Consequently, silvestrol has demonstrated the capability to inhibit the growth of numerous cancer cell lines at low nanomolar concentrations [11][12][13][14], especially targeting mRNAs with highly structured 5′UTR that are heavily reliant on eIF4A for translation [15].…”
Section: Introductionmentioning
confidence: 99%