Molecular intrinsic proximal interaction infer oxidative stress and apoptosis modulated in vivo biocompatibility of P.niruri contrived antibacterial iron oxide nanoparticles with zebrafish

Sheel, Rishav; Kumari, Puja; Panda, Pritam Kumar; Ansari, Danish Jawed; Patel, Paritosh; Singh, Swapnil; Kumari, Baby; Sarkar, Biplab; Mallick, M. A.; Verma, Suresh K.

doi:10.1016/j.envpol.2020.115482

Cited by 44 publications

(26 citation statements)

References 49 publications

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“…The phytochemicals and secondary metabolites found in plant extracts act as capping agent, and responsible for the reduction of metal ions and formation of NPs. Green synthesized metal/metal oxide NPs like CuO, FeO, and MgO are being utilized enormously in biomedical and clinical applications (Kumari et al, 2018;Sheel et al, 2020;Verma et al, 2020). Instead, AgNPs are preferred over other noble metal NPs like Au, Pt, Pd, Cu, Fe, etc., due to their extensive uses in bioengineering, cosmetics, food packaging, catalysis, electrochemistry, environmental remediation, and pharmaceutical industries as antiseptic agents (Paul et al, 2018;Mohan et al, 2020;Yousaf et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic, Antimitotic, DNA Binding, Photocatalytic, H2O2 Sensing, and Antioxidant Properties of Biofabricated Silver Nanoparticles Using Leaf Extract of Bryophyllum pinnatum (Lam.) Oken

Chandraker

Lal

Dhruve

et al. 2021

Front. Mol. Biosci.

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Bryophyllum pinnatum is a perennial herb traditionally used in ethnomedicine. In the present report, silver nanoparticles (AgNPs) were synthesized using B. pinnatum leaf extract. BP-AgNPs were confirmed following UV-Vis spectroscopy with SPR peak at 412 nm and further characterized by FTIR, XRD, SEM-EDX, and TEM. Microscopic images confirmed the spherical shape and ~15 nm average size of nanostructures. BP-AgNPs were evaluated for photocatalytic degradation of hazardous dyes (methylene blue and Rhodamine-B) and showed their complete reduction within 100 and 110 min., respectively. BP-AgNPs have emerged as a unique SPR-based novel sensor for the detection of H2O2, which may deliver exciting prospects in clinical and industrial areas. DPPH and ABTS free radical scavenging activity were studied with respective IC50 values of 89 and 259 μg/mL. A strong intercalating interaction of CT-DNA with BP-AgNPs was investigated. Observed chromosomal abnormalities confirm the antimitotic potential of BP-AgNPs in the meristematic root tip. The cytotoxicity of BP-AgNPs against B16F10 (melanoma cell line) and A431 (squamous cell carcinoma cell line), was assessed with respective IC50 values of 59.5 and 96.61 μg/ml after 24 h of treatment. The presented green synthetic approach provides a novel and new door for environmental, industrial, and biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic, Antimitotic, DNA Binding, Photocatalytic, H2O2 Sensing, and Antioxidant Properties of Biofabricated Silver Nanoparticles Using Leaf Extract of Bryophyllum pinnatum (Lam.) Oken

Chandraker

Lal

Dhruve

et al. 2021

Front. Mol. Biosci.

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“…Superparamagnetic iron oxide nanoparticles (SPIONs) are single-domain IONPs with a diameter of a few to a few tens nanometers that exhibit no remanent magnetization in the absence of an external magnetic field at room temperature. The superparamagnetic property of SPIONs, as well as their relatively good biocompatibility (Heine et al, 2014;Sheel et al, 2020), makes them the currently most used iron oxide-based T 2 contrast agents (Kwon et al, 2018). Generally, large SPIONs provide T 2 contrast due to the magnetic inhomogeneity induced by their strong magnetic moment.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Surface Coating of Iron Oxide Nanoparticles on Magnetic Resonance Imaging Relaxivity

Ahmadpoor

Masood

Feliu

et al. 2021

Front. Nanotechnol.

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Iron oxide nanoparticles (IONPs) with acceptable biocompatibility and size-dependent magnetic properties can be used as efficient contrast agents in magnetic resonance imaging (MRI). Herein, we have investigated the impact of particle size and surface coating on the proton relaxivity of IONPs, as well as engineering of small IONPs' surface coating as a strategy for achieving gadolinium-free contrast agents. Accordingly, polymer coating using poly(isobutylene-alt-maleic anhydride) (PMA) with overcoating of the original ligands was applied for providing colloidal stability to originally oleic acid–capped IONPs in aqueous solution. In case of replacement of the original ligand shell, the polymer had been modified with dopamine. Furthermore, the colloidal stability of the polymer-coated IONPs was evaluated in NaCl and bovine serum albumin (BSA) solutions. The results indicate that the polymer-coated IONPs which involved replacement of the original ligands exhibited considerably better colloidal stability and higher proton relaxivity in comparison to polymer-coated IONPs with maintained ligand shell. The highest r2/r1 we obtained was around 300.

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“…As many fundamental cellular pathways involved in the response to toxicants or stresses are highly conserved between the zebrafish and mammals, it has been considered as a 'gold standard' for environmental toxicity assessment [18]. More recently, it has been demonstrated to be a useful model for evaluating the environmental health and safety impacts of engineered nanomaterials and nanoscale products, which are increasingly being produced as a result of developments in nanotechnology [17][18][19][20][21][22][23][24][25][26]. In addition, benefited by the size and transparent body, zebrafish could be used to observe the impact of NPs on the induction of reactive oxygen species and apoptosis pathways at the cellular level [17,20,23,24,26,27].…”

Section: Introductionmentioning

confidence: 99%

Opportunistic gill infection is associated with TiO2 nanoparticle-induced mortality in zebrafish

Huang

Liu

et al. 2021

PLoS ONE

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The large amounts of engineered titanium dioxide nanoparticles (TiO2NPs) that have been manufactured have inevitably been released into the ecosystem. Reports have suggested that TiO2 is a relatively inert material that has low toxicity to animals. However, as various types of NPs increasingly accumulate in the ocean, their effects on aquatic life-forms remain unclear. In this study, a zebrafish model was used to investigate TiO2NP-induced injury and mortality. We found that the treatment dosages of TiO2NP are positively associated with increased motility of zebrafish and the bacterial counts in the water. Notably, gill but not dorsal fin and caudal fin of the zebrafish displayed considerably increased bacterial load. Metagenomic analysis further revealed that gut microflora, such as phyla Proteobacteria, Bacteroidetes, and Actinobacteria, involving more than 95% of total bacteria counts in the NP-injured zebrafish gill samples. These results collectively suggest that opportunistic bacterial infections are associated with TiO2NP-induced mortality in zebrafish. Infections secondary to TiO2NP-induced injury could be a neglected factor determining the detrimental effects of TiO2NPs on wild fish.

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Molecular intrinsic proximal interaction infer oxidative stress and apoptosis modulated in vivo biocompatibility of P.niruri contrived antibacterial iron oxide nanoparticles with zebrafish

Cited by 44 publications

References 49 publications

Cytotoxic, Antimitotic, DNA Binding, Photocatalytic, H2O2 Sensing, and Antioxidant Properties of Biofabricated Silver Nanoparticles Using Leaf Extract of Bryophyllum pinnatum (Lam.) Oken

Cytotoxic, Antimitotic, DNA Binding, Photocatalytic, H2O2 Sensing, and Antioxidant Properties of Biofabricated Silver Nanoparticles Using Leaf Extract of Bryophyllum pinnatum (Lam.) Oken

The Effect of Surface Coating of Iron Oxide Nanoparticles on Magnetic Resonance Imaging Relaxivity

Opportunistic gill infection is associated with TiO2 nanoparticle-induced mortality in zebrafish

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