Molecular mechanism of plant stress hormone methyl jasmonate for its anti-inflammatory activity

Gunjegaonkar, S M; Shanmugarajan, T. S.

doi:10.1080/15592324.2019.1642038

Cited by 15 publications

(7 citation statements)

References 63 publications

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“…Methyl jasmonate is a natural derivative of jasmonic acid, which plays a role in plant defense, germination, growth, ripening, and senescence. Methyl jasmonate can induce the plant to produce anti-microbial phytoalexins, nicotine, or protease inhibitors [178,179] through interaction with NF-κB signaling pathways which is involved in various inflammatory cascades and regulate adaptive immune responses [180]. Accordingly, methyl jasmonate was tested and found to have a potent impact on cancer cells where it induced cytochrome C release in the mitochondria leading to cell death [181].…”

Section: Methyl Jasmonatementioning

confidence: 99%

The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids

Ciebiera

Ali

Prince

et al. 2020

JCM

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Uterine fibroids (UFs) remain a significant health issue for many women, with a disproportionate impact on women of color, likely due to both genetic and environmental factors. The prevalence of UFs is estimated to be approximately 70% depending on population. UF-derived clinical symptoms include pelvic pain, excessive uterine bleeding, gastrointestinal and voiding problems, as well as impaired fertility. Nowadays numerous methods of UF treatment are available—from conservative treatment to invasive surgeries. Selecting an appropriate treatment option should be individualized and adjusted to the patient's expectations as much as possible. So far, the mainstay of treatment is surgery, but their negative impact of future fertility is clear. On the other hand, emerging new pharmaceutical options have significant adverse effects like liver function impairment, hot flashes, bone density loss, endometrial changes, and inability to attempt conception during treatment. Several natural compounds are found to help treat UFs and relieve their symptoms. In this review we summarize all the current available data about natural compounds that may be beneficial for patients with UFs, especially those who want to preserve their future fertility or have treatment while actively pursuing conception. Vitamin D, epigallocatechin gallate, berberine, curcumin, and others are being used as alternative UF treatments. Moreover, we propose the concept of using combined therapies of natural compounds on their own or combined with hormonal agents to manage UFs. There is a strong need for more human clinical trials involving these compounds before promoting widespread usage.

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Section: Methyl Jasmonatementioning

confidence: 99%

The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids

Ciebiera

Ali

Prince

et al. 2020

JCM

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“…In the regulatory network of JAZ gene family members, JAZ proteins constitute not only an important component of JA signaling but also play an important role in the interaction between JA signals and other hormone signals [ 68 , 69 ]. JAZ s can interact with DELLA (highly conserved N-terminal DELLA motif) proteins to indirectly regulate gibberellin (GA) signaling, and DELLA proteins are important repressor proteins in the GA signal transduction pathway [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Identification, Characterization and Expression Analysis of the JAZ Gene Family in Resistance to Gray Leaf Spots in Tomato

Sun

Liu

et al. 2021

IJMS

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The plant disease resistance system involves a very complex regulatory network in which jasmonates play a key role in response to external biotic or abiotic stresses. As inhibitors of the jasmonic acid (JA) signaling pathway, JASMONATE ZIM domain (JAZ) proteins have been identified in many plant species, and their functions are gradually being clarified. In this study, 26 JAZ genes were identified in tomato. The physical and chemical properties, predicted subcellular localization, gene structure, cis-acting elements, and interspecies collinearity of 26 SlJAZ genes were subsequently analyzed. RNA-seq data combined with qRT-PCR analysis data showed that the expression of most SlJAZ genes were induced in response to Stemphylium lycopersici, methyl jasmonate (MeJA) and salicylic acid (SA). Tobacco rattle virus RNA2-based VIGS vector (TRV2)-SlJAZ25 plants were more resistant to tomato gray leaf spots than TRV2-00 plants. Therefore, we speculated that SlJAZ25 played a negative regulatory role in tomato resistance to gray leaf spots. Based on combining the results of previous studies and those of our experiments, we speculated that SlJAZ25 might be closely related to JA and SA hormone regulation. SlJAZ25 interacted with SlJAR1, SlCOI1, SlMYC2, and other resistance-related genes to form a regulatory network, and these genes played an important role in the regulation of tomato gray leaf spots. The subcellular localization results showed that the SlJAZ25 gene was located in the nucleus. Overall, this study is the first to identify and analyze JAZ family genes in tomato via bioinformatics approaches, clarifying the regulatory role of SlJAZ25 genes in tomato resistance to gray leaf spots and providing new ideas for improving plant disease resistance.

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“…The spectrum of intracellular signaling pathways regulated by oxylipins is broad: from protein kinase c-beta (PKC-β) to nuclear factor NF-κB and peroxisome proliferation activator receptor (PPAR) ( Figure 7 ). Due to a significant number of regulated signaling pathways, plant oxylipins show a wide range of biological activities, from suppression of the inflammatory response to regulation of the cell cycle and apoptosis, however, the listed intracellular pathways are the most frequent targets for plant oxylipins [ 101 ].…”

Section: Potential Cellular Targets For Inflammation Allergy and Canc...mentioning

confidence: 99%

Therapeutic Potential of Plant Oxylipins

Savchenko

Degtyaryov

Radzyukevich

et al. 2022

IJMS

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For immobile plants, the main means of protection against adverse environmental factors is the biosynthesis of various secondary (specialized) metabolites. The extreme diversity and high biological activity of these metabolites determine the researchers’ interest in plants as a source of therapeutic agents. Oxylipins, oxygenated derivatives of fatty acids, are particularly promising in this regard. Plant oxylipins, which are characterized by a diversity of chemical structures, can exert protective and therapeutic properties in animal cells. While the therapeutic potential of some classes of plant oxylipins, such as jasmonates and acetylenic oxylipins, has been analyzed thoroughly, other oxylipins are barely studied in this regard. Here, we present a comprehensive overview of the therapeutic potential of all major classes of plant oxylipins, including derivatives of acetylenic fatty acids, jasmonates, six- and nine-carbon aldehydes, oxy-, epoxy-, and hydroxy-derivatives of fatty acids, as well as spontaneously formed phytoprostanes and phytofurans. The presented analysis will provide an impetus for further research investigating the beneficial properties of these secondary metabolites and bringing them closer to practical applications.

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Molecular mechanism of plant stress hormone methyl jasmonate for its anti-inflammatory activity

Cited by 15 publications

References 63 publications

The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids

The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids

Genome-Wide Identification, Characterization and Expression Analysis of the JAZ Gene Family in Resistance to Gray Leaf Spots in Tomato

Therapeutic Potential of Plant Oxylipins

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