Molecular mechanisms of anticancer effect of rutin

Imani, Amir; Maleki, Nasrin; Bohlouli, Sepideh; Kouhsoltani, Maryam; Sharifi, Simin; Dizaj, Solmaz Maleki

doi:10.1002/ptr.6977

Cited by 130 publications

(74 citation statements)

References 118 publications

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“…The role of PLP1 in bladder cancer has not been determined and requires further study. RELN is also associated with the WNT signalling pathway, which plays a signi cant role in initiation, progression, and metastasis in various types of cancers 24 . Furthermore, as determined using the TIMER algorithm, various mutation types in the four hub genes, especially deletions, were signi cantly associated with immune cells in bladder cancer, and the deletion of hub genes can reduce the level of immune in ltration in multiple immune cell types (supplemental online Table 1 and Table 2).…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Identification of Hub Genes related to the Progression of Bladder Cancer by an Integrated Bioinformatics Analysis

Wang

Chen

Liao

et al. 2021

Preprint

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BACKGROUND and OBJECTIVE: A better understanding of the molecular mechanisms underlying bladder cancer is necessary to identify candidate therapeutic targets. METHODS: We screened for genes associated with bladder cancer progression and prognosis. Publicly available expression data were obtained from TCGA and GEO to identify differentially expressed genes (DEGs) between bladder cancer and normal bladder tissues. Weighted co-expression networks were constructed, and Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Associations between hub genes and immune infiltration and immune therapy were evaluated. RESULTS: 3461 DEGs in TCGA-BC and 1069 DEGs in the GSE dataset were identified, with 87 overlapping differentially expressed genes between the bladder cancer and normal bladder groups. Hub genes in the tumour group were mainly enriched for cell proliferation-related GO terms and KEGG pathways, while hub genes in the normal group were related to the synthesis and secretion of neurotransmitters. PPI networks for the genes identified in the normal and tumour groups were constructed. Based on a survival analysis, CDH19, RELN, PLP1, and TRIB3 were significantly associated with prognosis (P < 0.05). Four hub genes were significantly enriched in the MAPK signalling pathway, VEGF signalling pathway, WNT signalling pathway, cell cycle, and P53 signalling pathway based on a gene set enrichment analysis; these genes were associated with immune infiltration levels in bladder cancer. CONCLUSIONS: CDH19, RELN, PLP1, and TRIB3 may play important roles in the development of bladder cancer and are potential therapeutic and prognostic targets.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Identification of Hub Genes related to the Progression of Bladder Cancer by an Integrated Bioinformatics Analysis

Wang

Chen

Liao

et al. 2021

Preprint

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“…One of the greatest group of phytochemicals with a broad spectrum of biological activities is polyphenols. A number of articles focusing on the anticancer effect of polyphenols have been released in the past decades [ 11 , 12 , 13 , 14 ]. Among them, chalcones, the precursors of flavonoid biosynthesis in higher plants, attract attention for a wide spectrum of biological actions with clinical potential [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Michalková¹,

Mirossay²,

Gazdova³

et al. 2021

Cancers

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Although great progress has been made in the treatment of cancer, the search for new promising molecules with antitumor activity is still one of the greatest challenges in the fight against cancer due to the increasing number of new cases each year. Chalcones (1,3-diphenyl-2-propen-1-one), the precursors of flavonoid synthesis in higher plants, possess a wide spectrum of biological activities including antimicrobial, anti-inflammatory, antioxidant, and anticancer. A plethora of molecular mechanisms of action have been documented, including induction of apoptosis, autophagy, or other types of cell death, cell cycle changes, and modulation of several signaling pathways associated with cell survival or death. In addition, blockade of several steps of angiogenesis and proteasome inhibition has also been documented. This review summarizes the basic molecular mechanisms related to the antiproliferative effects of chalcones, focusing on research articles from the years January 2015–February 2021.

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“…The moisture content and starch content of TBBF were lower than those of TBF and TBCF, while its mineral, protein, lipid, and rutin contents were much higher than those of TBF and TBCF. As a flavonoid, rutin has many health-promoting functions, such as antioxidant, anti-inflammatory, anti-tumor, and antiviral activities, among others [ 22 , 23 ]. The rutin content of TBBF was as high as 3.27%, which was higher than that of common cereal flour.…”

Section: Resultsmentioning

confidence: 99%

Effects of Tartary Buckwheat Bran Flour on Dough Properties and Quality of Steamed Bread

Zhang

Chen

Geng

et al. 2021

Foods

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Steamed bread is a traditional staple food of China. Replacing wheat flour (WF) with Tartary buckwheat is expected to improve the nutritional value of steamed bread. In this study, Tartary buckwheat flour (TBF), Tartary buckwheat bran flour (TBBF), and Tartary buckwheat core flour (TBCF) were prepared, their composition and physicochemical properties were compared. It was found that TBBF had higher protein and rutin contents, so its antioxidant activity and dough rheological properties were obviously superior to those of TBF and TBCF. When TBBF was mixed with WF, its weight proportion in the blend (Wbran) had a significant effect on the dough rheological properties. When Wbran was 30%, the dough had the optimal mixing tolerance, and when Wbran exceeded 30%, it caused dilution effect, weakening the gluten network. With the increase of Wbran, the color of the steamed bread developed by the TBBF–WF blend gradually darkened and yellowed, the specific volume declined, and its hardness, gumminess, and chewiness ascended gradually. The appropriate addition of TBBF (Wbran = 10% and 30%) was beneficial to cell diameter and volume of steamed bread, but the further rise of Wbran would destroy its gas retention ability. The predicted glycemic index (pGI) of steamed bread declined significantly with the increasing Wbran.

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Molecular mechanisms of anticancer effect of rutin

Cited by 130 publications

References 118 publications

WITHDRAWN: Identification of Hub Genes related to the Progression of Bladder Cancer by an Integrated Bioinformatics Analysis

WITHDRAWN: Identification of Hub Genes related to the Progression of Bladder Cancer by an Integrated Bioinformatics Analysis

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Effects of Tartary Buckwheat Bran Flour on Dough Properties and Quality of Steamed Bread

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