Molecular mechanisms regulating the pharmacological actions of icariin with special focus on PI3K-AKT and Nrf-2 signaling pathways

Verma, Aanchal; Aggarwal, Kritika; Agrawal, Ritik; Pradhan, Kajal; Goyal, Ahsas

doi:10.1007/s11033-022-07778-3

Cited by 15 publications

(7 citation statements)

References 53 publications

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“…In the next study, we will focus on G-CSF/IKK/NF- κ B-mediated neuroinflammation and apoptosis and the neuroprotective molecular mechanism of the pharmacological effects of ICA. Additionally, the neuroprotective mechanisms mediated by two important pathways that are the pharmacodynamic basis of ICA, the phosphoinositide 3-kinase/protein kinase B (PI3K-Akt) and nuclear red blood cell 2-related factor 2 (Nrf-2) pathways, may also have neuroprotective effects on neonatal mouse HIBD, which is worthy of exploration in future research [ 95 ]. A preprint has previously been published [ 96 ].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Mechanism of Icariin on Hypoxic Ischemic Brain Damage in Neonatal Mice

Wang

Yang

Zhou

et al. 2022

Oxidative Medicine and Cellular Longevity

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Objective. Our previous results showed that icariin (ICA) could inhibit apoptosis and provide neuroprotection against hypoxic-ischemic brain damage (HIBD) in neonatal mice, but the specific mechanism of its neuroprotective effect remains unknown. This study aims at exploring whether ICA plays a neuroprotective role in apoptosis inhibition by regulating autophagy through the estrogen receptor α (ERα)/estrogen receptor β (ERβ) pathway in neonatal mice with HIBD. Methods. A neonatal mouse model of HIBD was constructed in vivo, and an oxygen and glucose deprivation (OGD) model in HT22 cells from the hippocampal neuronal system was constructed in vitro. The effects of ICA pretreatment on autophagy and the expression of ERα and ERβ were detected in vitro and in vivo, respectively. ICA pretreatment was also supplemented with the autophagy inhibitor 3-methyladenine (3-MA), ERα inhibitor methylpiperidino pyrazole (MPP), and ERβ inhibitor 4-(2-phenyl-5,7-bis (trifluoromethyl) pyrazolo [1,5-a] pyramidin-3-yl) phenol (PHTPP) to further detect whether ICA pretreatment can activate the ERα/ERβ pathway to promote autophagy and reduce HIBD-induced apoptosis to play a neuroprotective role against HIBD in neonatal mice. Results. ICA pretreatment significantly promoted autophagy in HIBD mice. Treatment with 3-MA significantly inhibited the increase in autophagy induced by ICA pretreatment, reversed the neuroprotective effect of ICA pretreatment, and promoted apoptosis. Moreover, ICA pretreatment significantly increased the expression levels of the ERα and ERβ proteins in HIBD newborn mice. Both MPP and PHTPP administration significantly inhibited the expression levels of the ERα and ERβ proteins activated by ICA pretreatment, reversed the neuroprotective effects of ICA pretreatment, inhibited the increase in autophagy induced by ICA pretreatment, and promoted apoptosis. Conclusion. ICA pretreatment may promote autophagy by activating the ERα and ERβ pathways, thus reducing the apoptosis induced by HIBD and exerting a neuroprotective effect on neonatal mice with HIBD.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective Mechanism of Icariin on Hypoxic Ischemic Brain Damage in Neonatal Mice

Wang

Yang

Zhou

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…ginkgetin [77], quercetin [78], robinetin [75], apigenin [75], luteolin [79], hyperin [77], and icariin [80].…”

Section: Icariin a Novel Phytochemical With Favored Medicament Proper...mentioning

confidence: 99%

“…This phytoestrogen was first isolated and identified in 1990 and is believed to exert several favored biological characteristics, including antiosteoporosis, antidepression, anti-inflammatory, antioxidant, and antitumor activities [81,82]. The modulation of various signaling pathways such as MiR-223-3p/ NALP3, IGF-1, TLR4/ NF-κB, PI3K/Akt, NFκB/ NALP3, Wnt1/ β-catenin, and Nrf-2 are documented as the basic mechanisms by which icariin possess its pharmacological and therapeutical functions [77].…”

Section: Icariin a Novel Phytochemical With Favored Medicament Proper...mentioning

confidence: 99%

The Role of Nursing Care in the Management of Patients with Traumatic Subarachnoid Hemorrhage

Mousavi

Khastehband

Poudineh

et al. 2023

GMJ

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Ovarian cancer is described as one of the most common types of cancer and the leading cause of cancer-related deaths due to the high aggressiveness of this malignancy. However, the current therapeutically strategies failed to confront ovarian cancer or are accompanied by significant adverse effects leading to the recurrence of the disease and/or affecting the quality of life of survivors. On the other hand, ovarian cancer is recognized as a heterogenous disorder that is specified by alteration in a variety of molecular and cellular markers. Thereby, researchers are keen to find a novel therapeutical strategy representing high efficacy and safety, as well as be able to modulate altered biomolecules and signaling pathways. Icariin is a phytoestrogen with desired properties that are suggested for several chronic complications, particularly different types of cancer. The aim of the present study was to reveal the ameliorative characteristics of icariin and then discuss the antitumoral activities of this phytochemical against ovarian cancer with an emphasis on the modified molecular signaling pathways.

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“…The following proteins are being investigated as potential selective markers for nutraceuticals targeting MeHg+-induced experimental ALS in rats. We measured their levels to ascertain how icariin affects the neuronal cell proteins SIRT-1, Nrf-2, and HO-1 [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Icariin prevents methylmercury-induced experimental neurotoxicity: Evidence from cerebrospinal fluid, blood plasma, brain samples, and in-silico investigations

Sharma,

Mehan,

Khan

et al. 2024

Heliyon

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Molecular mechanisms regulating the pharmacological actions of icariin with special focus on PI3K-AKT and Nrf-2 signaling pathways

Cited by 15 publications

References 53 publications

Neuroprotective Mechanism of Icariin on Hypoxic Ischemic Brain Damage in Neonatal Mice

Neuroprotective Mechanism of Icariin on Hypoxic Ischemic Brain Damage in Neonatal Mice

The Role of Nursing Care in the Management of Patients with Traumatic Subarachnoid Hemorrhage

Icariin prevents methylmercury-induced experimental neurotoxicity: Evidence from cerebrospinal fluid, blood plasma, brain samples, and in-silico investigations

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