Molecular Mechanisms Underlying Oxytosis

Dolga, Amalia M.; Oppermann, Sina; Richter, Margret; Honrath, Birgit; Neitemeier, Sandra; Jelinek, Anja; Ganjam, Goutham K.; Culmsee, Carsten

doi:10.1002/9781119432463.ch14

Cited by 6 publications

(2 citation statements)

References 179 publications

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“…Since 2001 a number of other laboratories have provided additional key insights into the oxytosis pathway, including those of Axel Methner (Albrecht et al, 2010), Marcus Conrad (Seiler et al, 2008), Carsten Culmsee (Dolga et al, 2018), and Rajiv Ratan (Ratan, 2020), as will be described below.…”

Section: The History Of Oxytosis and Ferroptosismentioning

confidence: 99%

Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

Maher

Currais

Schubert

2020

Cell Chemical Biology

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Section: The History Of Oxytosis and Ferroptosismentioning

confidence: 99%

Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

Maher

Currais

Schubert

2020

Cell Chemical Biology

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“…[ 6 ] Glutamate can reduce cystine input by inhibiting the cysteine/glutamate transport system, leading to intracellular glutathione (GSH) depletion and decreased GPX4 activity, which in turn leads to cell death due to excessive oxidative stress. [ 7 ] It is always used as an aging model inducer. In this study, glutamate treatment was also used to construct a cellular model of aging to explore the resistance of DHMBA to aging caused by glutamate.…”

Section: Introductionmentioning

confidence: 99%

Potential Function of 3,5‐Dihydroxy‐4‐Methoxybenzyl Alcohol from Pacific Oyster (Crassostrea gigas) in Brain of Old Mice

Chen,

Liu,

Chen

et al. 2024

Molecular Nutrition Food Res

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Scope3,5‐Dihydroxy‐4‐methoxybenzyl alcohol (DHMBA) is found in oyster extracts in recent years and is reported to have antioxidant activity. Although it has been reported to be protective in various models of oxidative stress, the therapeutic effect of DHMBA on neurological damage caused by aging remains to be demonstrated.Methods and ResultsThe present study investigates the potential functions of DHMBA in brain of old C57BL/6J mice and aging cell model. Administration of DHMBA improves working memory, reduces anxiety behavior, decreases the expression levels of cell cycle proteins, cycin‐dependent kinase inhibitor 1(P21) and peptidase inhibitor 16(P16) and inhibits neuronal loss in old mice. The data obtained from the aging cell model are consistent with those from the old mice. The interaction between DHMBA and Kelch‐like ECH‐associated protein 1 (Keap1) is predicted by molecular docking assay, and then it is verified by co‐immunopricipitation (CoIP) that factor red lineage 2‐related factor 2 (Nrf2)‐Keap1 protein‐protein interaction is inhibited by DHMBA. Protein levels of Nrf2 and its target genes, such as glutathione peroxidase 4(GPX4) and heme oxygenase 1 (HO‐1), are detected in old mice and aging cell model.ConclusionThis study provides new evidence that explores the antioxidant mechanism of DHMBA and implies a potential role of DHMBA on antiaging in brain.

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Inhibitors of Oxytosis/Ferroptosis: A New Class of Therapeutics for Alzheimer’s Disease

Maher

2023

Ferroptosis in Health and Disease

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Molecular Mechanisms Underlying Oxytosis

Cited by 6 publications

References 179 publications

Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

Potential Function of 3,5‐Dihydroxy‐4‐Methoxybenzyl Alcohol from Pacific Oyster (Crassostrea gigas) in Brain of Old Mice

Inhibitors of Oxytosis/Ferroptosis: A New Class of Therapeutics for Alzheimer’s Disease

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