Molecular mobility in Soluplus, a polymer with extremely low dynamic fragility; A study by thermally stimulated depolarization currents

Diogo, Hermı́nio P.; Ramos, Joaquim J. Moura

doi:10.1016/j.jnoncrysol.2022.121738

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…The knowledge and techniques about solid dispersions (SDs) are always being updated due to the continuous increase of poorly water-soluble drugs from high-throughput chemistry and bioengineering ( Inocencio, et al, 2020 ; Bigogno, et al, 2021 ; Diogo and Ramos, 2022a ; Diogo and Ramos, 2022b ; Du et al, 2023a ; Du et al, 2023b ). In general, there are a series of factors that always co-act to ensure high-quality SDs for poorly water-soluble drugs.…”

Section: Introductionmentioning

confidence: 99%

The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions

Wang

Lü

Yang

et al. 2023

Front. Mol. Biosci.

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Based on a working fluid consisting of a poorly water-soluble drug and a pharmaceutical polymer in an organic solvent, electrospinning has been widely exploited to create a variety of amorphous solid dispersions However, there have been very few reports about how to prepare the working fluid in a reasonable manner. In this study, an investigation was conducted to determine the influences of ultrasonic fluid pretreatment on the quality of resultant ASDs fabricated from the working fluids. SEM results demonstrated that nanofiber-based amorphous solid dispersions from the treated fluids treated amorphous solid dispersions exhibited better quality than the traditional nanofibers from untreated fluids in the following aspects: 1) a straighter linear morphology; 2) a smooth surface; and 3) a more evener diameter distribution. The fabrication mechanism associated with the influences of ultrasonic treatments of working fluids on the resultant nanofibers’ quality is suggested. Although XRD and ATR–FTIR experiments clearly verified that the drug ketoprofen was homogeneously distributed all over the TASDs and the traditional nanofibers in an amorphous state regardless of the ultrasonic treatments, the in vitro dissolution tests clearly demonstrated that the TASDs had a better sustained drug release performance than the traditional nanofibers in terms of the initial release rate and the sustained release time periods.

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