Molecular modeling studies and synthesis of novel quinoxaline derivatives with potential anticancer activity as inhibitors of c-Met kinase

TsNBr2 Mediated Synthesis of 2‐Acylbenzothiazoles and Quinoxalines from Aryl Methyl Ketones under Metal Free Condition

“…The formation of phenylglyoxal intermediate during benzothiazole synthesis motivated us to undertake an investigation for synthesizing corresponding quinoxalines. Quinoxaline derivatives have been reported with anticancer, antitumor, antituberculosis, anti‐inflammatory, antibacterial, and anti‐HIV . activities.…”

Sulfoxonium ylides for direct methylation of N-heterocycles in water

“…General methods. For the synthetic procedure and 1 H, 13 General procedure for the methylation of 3a. To an oven-dried sealed tube charged with 1-methyl-5phenylpyrazinone (1a) (37.6 mg, 0.2 mmol, 1.0 equiv.…”

“…To address this challenge, number of synthetic strategies have been explored to install methyl and alkyl groups on N-heterocyclic molecules [7][8][9] . In particular, alkylation beyond monoazines, i.e., that of diazines and triazines, has emerged as a hot topic in this area due to the relevance of a number of bioactive molecules [10][11][12][13][14] .…”

Crystal structure and Hirshfeld surface analysis of 1-[(1-butyl-1H-1,2,3-triazol-4-yl)methyl]-3-methylquinoxalin-2(1H)-one

“…Diversely substituted quinoxalines and their derivatives embedded with variety of functional groups are important biological agents and a significant amount of research activity has been directed towards this class of compounds. These molecules exhibit a wide range of biological applications and are potentially useful in medicinal chemistry research and have therapeutic applications such as antimicrobial (Attia et al, 2013;Vieira et al, 2014;Teja et al, 2016), anti-inflammatory (Guirado et al, 2012), anticancer (Abbas et al, 2015), antidiabetic (Kulkarni et al, 2012) and antihistaminic activities (Sridevi et al, 2010). As a continuation of our research works on the synthesis, spectroscopic and biological properties of quinoxaline derivatives (Ramli et al, 2013(Ramli et al, , 2017Ramli & Essassi, 2015;Abad et al, 2018a,b,c;Ellouz et al, 2015;Sebbar et al, 2014), we report herein the molecular and crystal structures along with the Hirshfeld surface analysis of the title compound, 1-[(1-butyl-1H-1,2,3triazol-5-yl)methyl]-3-methyl-1,2-dihydroquinoxalin-2-one.…”