Molecular relation between biological stress and carcinogenesis

Rakoczy, Katarzyna; Szlasa, Wojciech; Sauer, Natalia; Saczko, Jolanta; Kulbacka, Julita

doi:10.1007/s11033-022-07543-6

Cited by 1 publication

(2 citation statements)

References 210 publications

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“…We suggest that a link between copper level and pH may exist. The isotopic 63 Cu/ 65 Cu ratio in the serum of tumour patients also seems to be altered [74], with increasing levels of the lighter isotope. These changes could be due to increased glycolysis and lactate formation.…”

Section: Copper and Cancermentioning

confidence: 95%

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Multifactorial Distress, the Warburg Effect, and Respiratory and pH Imbalance in Cancer Development

Drochioiu

2023

Stresses

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Oncogenes are thought to play an important role in aberrant regulation of growth factors, which is believed to be an initiation event of carcinogenesis. However, recent genetic and pharmacological studies have shown that the Warburg effect (WE) is needed for tumour growth. It refers to extensively studied aerobic glycolysis over the past decade, although its impact on cancer remains unclear. Meanwhile, a large body of evidence has indicated that oxidative stress (OS) is connected with the occurrence and progression of various forms of cancer. Psychosocial factors (PSF), such as chronic depression, sadness, stressful life experiences, stress-prone personality, and emotional distress or poor quality of life affect the immune system and contribute to cancer outcomes. Here, we examine the relationship between WE, OS, PSF, metal ions, other carcinogens, and the development of different cancers from the viewpoint of physiological and biochemical mechanisms.

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Section: Copper and Cancermentioning

confidence: 95%

“…Several studies suggest that stress may influence oncogenic development, and data from subhuman experiments have shown that aggressive offenses can enhance or suppress oncogenicity [63,64]. Thus, psychological factors may affect the risk and progression of tumour proliferation [65].…”

Section: The Non-specific Stressmentioning

confidence: 99%

Multifactorial Distress, the Warburg Effect, and Respiratory and pH Imbalance in Cancer Development

Drochioiu

2023

Stresses

View full text Add to dashboard Cite

show abstract

Molecular relation between biological stress and carcinogenesis

Cited by 1 publication

References 210 publications

Multifactorial Distress, the Warburg Effect, and Respiratory and pH Imbalance in Cancer Development

Multifactorial Distress, the Warburg Effect, and Respiratory and pH Imbalance in Cancer Development

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