Molecular relaxations in radiationally crosslinked poly(vinyl methyl ether) hydrogels

Pastorczak, Marcin; Kadłubowski, Sławomir; Okrasa, Lidia; Kozanecki, Marcin; Boiteux, Gisèle; Rosiak, Janusz M.; Ulański, Jacek

doi:10.1016/j.jnoncrysol.2007.04.048

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Water in various states differs in terms of ability for crystallisation and also rotational and vibrational dynamics. [11][12][13]16,17,21,24,25,[30][31][32] Thus, these states may be distinguished by some experimental methods such as differential scanning calorimetry, 30 neutron scattering, 33,34 vibrational 16,17,31,32 and dielectric spectroscopies. 29,35,36 The diffusive properties of water as well as various useful additives (tracers, drugs, ionic and non-ionic solutes, nanoparticles) in polymer systems Fig.…”

Section: Introductionmentioning

confidence: 99%

Diffusive properties of solvent molecules in the neighborhood of a polymer chain as seen by Monte-Carlo simulations

et al. 2016

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The influence of both polymer chain length and concentration on the mobility of solvent molecules in polymer solutions was studied by Monte Carlo simulations with the use of the dynamic lattice liquid (DLL) model. The poly(vinylmethylether)-water system was used as a model. Two different solvent (water) states with differing mobilities were distinguished in polymer solutions. The first one with high molecular mobility independent of polymer concentration corresponds to bulk solvent in real systems. The second state relates to so called bound solvent. In this case the solvent diffusivity decreases with polymer content. For diluted solutions the diffusion of bound solvent is affected by polymer chain length, precisely, by the ability of the polymer chain to undergo coil formation.

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Section: Introductionmentioning

confidence: 99%

Diffusive properties of solvent molecules in the neighborhood of a polymer chain as seen by Monte-Carlo simulations

et al. 2016

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“…Polymer hydrogels are defined as physically or chemically crosslinked polymer networks to absorb a large amount of water without being dissolved [10,11]. There are two methods to prepare hydrogels using hydrophilic polymers.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives

2014

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Abstract:A mucoadhesive drug delivery system can improve the effectiveness of a drug by maintaining the drug concentration and allowing targeting and localization of the drug at a specific site. Acrylic-based hydrogels have been used extensively as a mucoadhesive system owing to their flexibility and excellent bioadhesion. In this experiment, poly(acrylic acid) was selected to prepare the bioadhesive hydrogel adhering to mucosal surfaces using a radiation process. Poly(acrylic acid) was dissolved in water to a prepare poly(acrylic acid) solution, and the solution was then irradiated by an electron beam at up to 75 kGy to make hydrogels. Their physical properties, such as gel percent, swelling percent and adhesive strength to mucosal surfaces, were investigated. Triamcinolone acetonide was used as a model drug. The dried poly(acrylic acid) film was dipped in a 0.1 wt% triamcinolone acetonide solution in ethanol, and then dried at 25 °C. The release of triamcinolone acetonide was determined at different time intervals, and UV (Ultraviolet)-Vis spectroscopy was used to determine the released concentration of triamcinolone acetonide at 238 nm. It was shown that poly(acrylic acid)-based drug carriers were successfully prepared for use in a bioadhesive drug delivery system.

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“…The crosslinking was performed by mean of electron-beam irradiation. Details of the radiation synthesis as well as of the sol-gel analysis may be found in our earlier papers [ 7 , 10 , 11 ]. The basic physical properties of studied samples are summarized in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

Poly(vinyl methyl ether) hydrogels at temperatures below the freezing point of water—molecular interactions and states of water

et al. 2014

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Water interacting with a polymer reveals a number of properties very different to bulk water. These interactions lead to the redistribution of hydrogen bonds in water. It results in modification of thermodynamic properties of water and the molecular dynamics of water. That kind of water is particularly well observable at temperatures below the freezing point of water, when the bulk water crystallizes. In this work, we determine the amount of water bound to the polymer and of the so-called pre-melting water in poly(vinyl methyl ether) hydrogels with the use of Raman spectroscopy, dielectric spectroscopy, and calorimetry. This analysis allows us to compare various physical properties of the bulk and the pre-melting water. We also postulate the molecular mechanism responsible for the pre-melting of part of water in poly(vinyl methyl ether) hydrogels. We suggest that above −60 °C, the first segmental motions of the polymer chain are activated, which trigger the process of the pre-melting.

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Molecular relaxations in radiationally crosslinked poly(vinyl methyl ether) hydrogels

Cited by 6 publications

References 26 publications

Diffusive properties of solvent molecules in the neighborhood of a polymer chain as seen by Monte-Carlo simulations

Diffusive properties of solvent molecules in the neighborhood of a polymer chain as seen by Monte-Carlo simulations

Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives

Poly(vinyl methyl ether) hydrogels at temperatures below the freezing point of water—molecular interactions and states of water

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