Molecular structure investigation, Hirshfeld surface analysis and DNA interaction of cadmium complex of 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide monohydrate in the presence of the secondary ligand β-picoline

Alalawy, Mohammed Dawood; Patel, Urmila H.; Padariya, Taruna J.; Chaudhary, Kaushik P.; Socha, Bhavesh N.; Chavda, Bhavin R.; Bhatt, Bhupesh S.; Patel, Nikita

doi:10.1016/j.poly.2021.115137

Cited by 5 publications

(1 citation statement)

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“…The final binding orientation among all possible conformation having optimal energy is considered as a docked pose with minimum energy, which shows that minor groove mode plays a predominant role in the interaction (Fig. 11 ) 45 , 93 – 95 . The relative binding energy of the docked structure was found − 213.45 kJ mol −1 .…”

Section: Resultsmentioning

confidence: 99%

Visible light-driven photocatalysts, quantum chemical calculations, ADMET-SAR parameters, and DNA binding studies of nickel complex of sulfadiazine

Pandya,

Socha,

Dubey

et al. 2023

Sci Rep

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A 3D-supramolecular nickel integrated Ni-SDZ complex was synthesized using sodium salt of sulfadiazine as the ligand and nickel(II) acetate as the metal salt using a condensation process and slow evaporation approach to growing the single crystal. The metal complex was characterized for its composition, functional groups, surface morphology as well as complex 3D structure, by resorting to various analytical techniques. The interacting surface and stability as well as reactivity of the complex were carried out using the DFT platform. From ADMET parameters, human Intestinal Absorbance data revealed that the compound has the potential to be well absorbed, and also Ni-SDZ complex cannot cross the blood–brain barrier (BBB). Additionally, the complex's DNA binding affinity and in-vivo and in-vitro cytotoxic studies were explored utilizing UV–Vis absorbance titration, viscosity measurements, and S. pombe cells and brine shrimp lethality tests. In visible light radiation, the Ni-SDZ complex displayed exceptional photo-degradation characteristics of approximately 70.19% within 70 min against methylene blue (MB).

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Section: Resultsmentioning

confidence: 99%