Molecular weight of polyethylenimine-dependent transfusion and selective antimicrobial activity of functional silver nanoparticles

Tiwari, Atul; Gupta, Mukul; Pandey, Ganesh; Narayan, Roger J.; Pandey, Prem C.

doi:10.1557/jmr.2020.183

Cited by 16 publications

(28 citation statements)

References 23 publications

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“…[156,157] In another example, through a fluorescence spectroscopic approach, Tiwari et al 2020, studied the interaction of polyethylenimine (PEI) functionalized silver nanoparticles with cells of Acinetobacter baumannii. [158] The reports have shown that the silver nanoparticles selectively bind with surfaceexpressed proteins, quenching the autofluorescence of proteins damaging the cell structures at shallow MIC values (≈5 µg mL −1 ). Similarly, they have also utilized other capping agents like 3-aminopropyletrimethoxysilane, 3-glysidoxypropyletrimthoxysilane and organic reducing agents' cyclohexanone and formaldehyde.…”

Section: Inactivation Strategies Of the Virus Before Entry In The Host Cellmentioning

confidence: 99%

“…The surface charge and size of silver nanoparticles with PEI capping can also be tuned as per requirement by using a varying molecular weight of PEI. [158] PEI molecules can be linear or branched. It has also been studied that the higher molecular weight of PEI functionalized silver nanoparticles had a more potent effect on the bacterial cell.…”

Section: Inactivation Strategies Of the Virus Before Entry In The Host Cellmentioning

confidence: 99%

“…The polyethyleneimines are cationic, hydrophilic polymers and functionalization of silver nanoparticles have great scope as an air disinfectant, antiviral surface coatings, antiviral coating of masks, PPE kits, and household exhausts as front-line defense material against COVID-19 or other viral and microbial pathogens from humans to plants. [158] Graphene and its derivatives are an exciting member of the carbon nanostructures group (graphene, the building block of graphite). Structurally, graphene's are anatomically 2D layers of hexagonally bonded carbon atoms.…”

Section: Inactivation Strategies Of the Virus Before Entry In The Host Cellmentioning

confidence: 99%

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Nanotechnology: A Potential Weapon to Fight against COVID‐19

Tiwari

Mishra

Pandey

et al. 2021

Part & Part Syst Charact

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the phylogenetic and taxonomical finding on February 11, the coronavirus (COV) study group (CGS) of the International Committee on Virus Taxonomy (ICTV) designated the virus as SARS-CoV-2. [1] The same day, the director general of the World Health Organization (WHO) designated the disease caused by SARS-CoV-2 "coronavirus disease 2019" (COVID-19). The WHO declared COVID-19 a pandemic On March 11, 2020. Globally as of June 2021, 179 686 071 confirmed cases of COVID-19, including 3 899 172 deaths, reported by WHO. [2] Reducing the burden of COVID-19 infection by developing vaccines and antiviral drugs is still a big challenge for researchers and clinicians.Nowadays, nanotechnology is a promising player in the scientific and medical fields with many applications. [3,4] A new dimension has been opened by the functionally tunable nanosized materials for industrial, biomedical, and scientific purposes, which provides a set of techniques that allow the manipulation of structural and functional properties on a microscale. [5,6] Nanotechnology is kindred with the biomedicinal involvement of nanoparticles (NPs), which are not only used as the backbone in the vaccine to formulate "nanovaccines," nanomaterial-based antiviral agents, disinfectants; which inhibit the multiplication within the host or inactivate them outside the host, but also the application of designed nanorobots to detect and repairs of tissue defects at the cellular level. [7,8] Unlike the conventional drug formulations, which typically circulate throughout the entire body parts, nanoparticles may target a desired part of the body as a targeted drug delivery vehicle. Compared to conventional vaccines, nanovaccines or surface-functionalized nanoparticles can be designed, explicitly targeting lymphatic organs and immune cells to provoke better immune responses. Moreover, the localized infections are challenging to be treated by the conventional vaccines but can be treated by the nanovaccines with specific cells or organ-targeting molecules. In some cases, the nanobased settings are applied to enhance the solubility of hydrophobic compounds. These systems are helpful to protect the antigens from degradation and stabilize a large number of therapeutic biomolecules, such as peptides, proteins, and nucleic acids on the substrate. [9] Viral infections, particularly COVID-19, have posed a severe threat to public health globally because of their wide-sphered distribution and their potent ability to change the genetic makeup. [10] Unfortunately, viruses have adopted various alternative tacticsThe COVID-19 infections have posed an unprecedented global health emergency, with nearly three million deaths to date, and have caused substantial economic loss globally. Hence, an urgent exploration of effective and safe diagnostic/therapeutic approaches for minimizing the threat of this highly pathogenic coronavirus infection is needed. As an alternative to conventional diagnosis and antiviral agents, nanomaterials have a great potential to cope with the current or even futu...

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Section: Inactivation Strategies Of the Virus Before Entry In The Host Cellmentioning

confidence: 99%

Section: Inactivation Strategies Of the Virus Before Entry In The Host Cellmentioning

confidence: 99%

Section: Inactivation Strategies Of the Virus Before Entry In The Host Cellmentioning

confidence: 99%

See 1 more Smart Citation

Nanotechnology: A Potential Weapon to Fight against COVID‐19

Tiwari

Mishra

Pandey

et al. 2021

Part & Part Syst Charact

Self Cite

View full text Add to dashboard Cite

show abstract

“…Because of the relatively low stability of colloidal solutions, numerous reports are devoted to investigations of stabilized silver nanoparticles [15][16][17][18][19][20][21][22][23][24][25]. A suitable stabilizer should be used to limit the growth of the silver particles and their aggregation.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, as long as there are not so many ways to create materials from nanoparticles, since their aggregation leads to the loss of most of the unique characteristics [7,13,14]. To prevent aggregation, it is necessary to use stabilizing agents, such as self-assembled monolayers [15,16], surfactants [17][18][19], polymers [20][21][22][23] or dendrimers [24,25]. These stabilizers protect the nanoparticles from the environment and prevent their agglomeration, and moreover play an important role in controlling the size and shape of the particles.…”

Section: Introductionmentioning

confidence: 99%

Guanidinium and Phosphonium Scaffolds Loaded with Silver Nanoparticles: Synthesis, Characterization, In Vitro Assessment of the Antibacterial Potential and Toxicity

Горбунова

Lemkina

Nechaev

2021

J Inorg Organomet Polym

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New silver nanocomposites based on polysulfones of 2,2-diallyl-1,1,3,3-tetraethylguanidiniumchloride [poly(AGC-SO )], tris(diethylamino)diallylaminophosphonium tetra uoroborate [poly(DAAP-BF 4 -SO 2 )] and chloride [poly(DAAP-Cl-SO 2 )] have been developed. UVspectroscopy, SEM and XRD techniques were used to characterize the formation of silver nanoparticles in copolymers. Antibacterial action of new silver nanocomposites on S. epidermidis 33 and Escherichia coli (planktonic cells and bio lms) was studied. The silver nanocomposites strongly inhibited bio lms formation of S. epidermidis 33 and Escherichia coli. The silver nanocomposites based on phosphonium polysulfones have a signi cant cytotoxic activity against RD and MS line cells.

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