Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy

Xu, Fangzhou; Zhu, Ling; Han, Hai-Hao; Zou, Jian-Wei; Zang, Yi; Li, Jia; James, Tony D.; He, Xiao‐Peng; Wang, Cheng-Yun

doi:10.1039/d2sc00889k

Cited by 17 publications

(6 citation statements)

References 48 publications

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“…PDT is a highly accurate method that prevents disease recurrence ( 286 ). Moreover, this method is comfortable and leaves virtually no scars, and apart from protection against light, it does not require any special precautions ( 287 ). In addition to the obvious advantages of PDT in cancer, some disadvantages hinder the clinical dissemination of this treatment method.…”

Section: Review Of the Literaturementioning

confidence: 99%

“…In patients with periodontitis with rapid progression and severe severity, photodynamic therapy improves the clinical condition, but should not be used as a substitute for amoxicillin and metronidazole (275). PDT causes a significant reduction of bacteria, but their complete elimination is usually not achieved (276)(277)(278)(279)(280)(281)(282)(283)(284)(285)(286)(287). It is also important to use the most selective photosensitizers possible, because killing the entire physiological flora of the oral cavity exposes patients to infections with opportunistic pathogens (276).…”

Section: -Ala Clinical Ester Methyl Aminolevulinate (Mal) Clinicalmentioning

confidence: 99%

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The use of photodynamic therapy in medical practice

Aebisher,

Rogóż,

Myśliwiec

et al. 2024

Front. Oncol.

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Cancer therapy, especially for tumors near sensitive areas, demands precise treatment. This review explores photodynamic therapy (PDT), a method leveraging photosensitizers (PS), specific wavelength light, and oxygen to target cancer effectively. Recent advancements affirm PDT’s efficacy, utilizing ROS generation to induce cancer cell death. With a history spanning over decades, PDT’s dynamic evolution has expanded its application across dermatology, oncology, and dentistry. This review aims to dissect PDT’s principles, from its inception to contemporary medical applications, highlighting its role in modern cancer treatment strategies.

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Section: Review Of the Literaturementioning

confidence: 99%

Section: -Ala Clinical Ester Methyl Aminolevulinate (Mal) Clinicalmentioning

confidence: 99%

The use of photodynamic therapy in medical practice

Aebisher,

Rogóż,

Myśliwiec

et al. 2024

Front. Oncol.

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show abstract

“…105 Second, in view of the fact that PDT kills cancer cells through instantaneously generated excess ROS, it can quickly and effectively kill all lesions of the light-irradiated site without missing potential minor lesions, which can greatly reduce the possibility of recurrence from invisible minimal lesions. 106 In addition, the hyperplastic tissue in skin cancer can accumulate more PSs, which can emit a unique brick-red fluorescence under the irradiation of ultraviolet light, making the boundary of cancer tissues visualized, facilitating the determination of treatment plan.…”

Section: Pros and Cons Of Pdt On Skin Cancermentioning

confidence: 99%

Global Trends and Research Progress of Photodynamic Therapy in Skin Cancer: A Bibliometric Analysis and Literature Review

Sun¹,

Zhao²,

Lin³

et al. 2023

CCID

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Background Based on photochemical reactions through the combined use of light and photosensitizers, photodynamic therapy (PDT) is gaining popularity for the treatment of skin cancer. Various photosensitizers and treatment regimens are continuously being developed for enhancing the efficacy of PDT on skin cancer. Reviewing the development history of PDT on skin cancer, and summarizing its development direction and research status, is conducive to the further research. Methods To evaluate the research trends and map knowledge structure, all publications covering PDT on skin cancer were retrieved and extracted from Web of Science database. We applied VOSviewer and CiteSpace softwares to evaluate and visualize the countries, institutes, authors, keywords and research trends. Literature review was performed for the analysis of the research status of PDT on skin cancer. Results A total of 2662 publications were identified. The elements, mechanism, pros and cons, representative molecular photosensitizers, current challenges and research progress of PDT on skin cancer were reviewed and summarized. Conclusion This study provides a comprehensive display of the field of PDT on skin cancer, which will help researchers further explore the mechanism and application of PDT more effectively and intuitively.

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“…Photodynamic therapy (PDT), as an emerging method for the treatment of cancer and bacteria, has attracted much attention due to its low invasiveness, toxicity, and drug resistance [1][2][3][4][5][6][7][8][9][10][11], among which, image-guided PDT is attracting increasing attention for its potential in the theranostics. It has been recognized that exploring high-performance luminescent photosensitizers is very important to the development of image-guided therapy.…”

Section: Introductionmentioning

confidence: 99%

Modulating the Luminescence, Photosensitizing Properties, and Mitochondria-Targeting Ability of D-π-A-Structured Dihydrodibenzo[a,c]phenazines

Zhang,

Wang,

Zhang

et al. 2023

Molecules

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Herein, pyridinium and 4-vinylpyridinium groups are introduced into the VIE-active N,N′-disubstituted-dihydrodibenzo[a,c]phenazines (DPAC) framework to afford a series of D-π-A-structured dihydrodibenzo[a,c]phenazines in consideration of the aggregation-benefited performance of the DPAC module and the potential mitochondria-targeting capability of the resultant pyridinium-decorated DPACs (DPAC-PyPF6 and DPAC-D-PyPF6). To modulate the properties and elucidate the structure–property relationship, the corresponding pyridinyl/4-vinylpyridinyl-substituted DPACs, i.e., DPAC-Py and DPAC-D-Py, are designed and studied as controls. It is found that the strong intramolecular charge transfer (ICT) effect enables the effective separation of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) of DPAC-PyPF6 and DPAC-D-PyPF6, which is conducive to the generation of ROS. By adjusting the electron-accepting group and the π-bridge, the excitation, absorption, luminescence, photosensitizing properties as well as the mitochondria-targeting ability can be finely tuned. Both DPAC-PyPF6 and DPAC-D-PyPF6 display large Stokes shifts (70–222 nm), solvent-dependent absorptions and emissions, aggregation-induced emission (AIE), red fluorescence in the aggregated state (λem = 600–650 nm), aggregation-promoted photosensitizing ability with the relative singlet-oxygen quantum yields higher than 1.10, and a mitochondria-targeting ability with the Pearson coefficients larger than 0.85. DPAC-D-PyPF6 shows absorption maximum at a longer wavelength, slightly redder fluorescence and better photosensitivity as compared to DPAC-PyPF6, which consequently leads to the higher photocytotoxicity under the irradiation of white light as a result of the larger π-conjugation.

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Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy

Abstract: Luminogens characteristic of aggregation-induced emission (AIEgens) have been engineered for the development of imaging-guided photodynamic therapeutic (PDT) agents.

Cited by 17 publications

References 48 publications

The use of photodynamic therapy in medical practice

The use of photodynamic therapy in medical practice

Global Trends and Research Progress of Photodynamic Therapy in Skin Cancer: A Bibliometric Analysis and Literature Review

Modulating the Luminescence, Photosensitizing Properties, and Mitochondria-Targeting Ability of D-π-A-Structured Dihydrodibenzo[a,c]phenazines

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