2000
DOI: 10.1039/b007221o
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Molecularly imprinted microparticles for capillary electrochromatographic enantiomer separation of propranolol

Abstract: Molecularly imprinted microparticles imprinted against (S)-propranolol were synthesised and studied for use in capillary electrochromatographic separation of propranolol enantiomers. The imprinted microparticles were in the size range of 0.2-0.5 micron as determined by scanning electron microscopy. The microparticles were suspended, in high concentration, in the electrolyte and used to perform enantiomer separation by a partial filling technique.

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Cited by 125 publications
(96 citation statements)
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“…Scintillation liquid Ecoscint XR was purchased from National Diagnostics (Hessle Hull, England). The free amine of propranolol was prepared as described by Schweitz et al [33].…”
Section: Synthesis Of Spherical Mip and Cp Beadsmentioning
confidence: 99%
“…Scintillation liquid Ecoscint XR was purchased from National Diagnostics (Hessle Hull, England). The free amine of propranolol was prepared as described by Schweitz et al [33].…”
Section: Synthesis Of Spherical Mip and Cp Beadsmentioning
confidence: 99%
“…Good success has been reported using polymer nanoparticles, many of them MIP nanoparticles, as PSPs [48][49][50][51][52][53]. Synthesis of nanoparticles with a narrow distribution of diameters from 0.2-0.5 mm and free of stabilizing surfactants was achieved by precipitation polymerization.…”
Section: Polymer Nanoparticlesmentioning
confidence: 98%
“…An MIP nanoparticle suspension templated with S-propanolol was used to achieve chiral resolution of propanolol in less than 1.5 min [48]. Particles imprinted with (1)-ephedrine and with diameters on the order of 100-200 nm were used as a PSP for the separation of the cationic ephedrine enantiomers [52].…”
Section: Chiral Separations With Mip Nanoparticlesmentioning
confidence: 99%
“…Due to their tunable selectivity and ease of preparation, the number of MIP-based applications is rapidly increasing. MIP-CEC systems have been recently developed through different approaches, namely as monolithic capillaries prepared by an in situ polymerization [1][2][3], open-tubular capillaries [4][5][6], polyacrylamide-entrapped MIPs [7,8], and partial filling techniques based on MIP micro-or nanoparticles [9][10][11]. The simple use of MIP-particles with a diameter , 10 mm to pack CEC capillaries has some serious limitations, the main being the fabrication of frits.…”
Section: Introductionmentioning
confidence: 99%