Molecularly imprinted nanoparticles prepared by core-shell emulsion polymerization

Pérez, Natalia; Whitcombe, Michael J.; Vulfson, Evgeny N.

doi:10.1002/1097-4628(20000822)77:8<1851::aid-app23>3.0.co;2-j

Cited by 144 publications

(58 citation statements)

References 31 publications

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“…Spherical particles can be created using precipitation polymerization [10,11]. Another method of preparing spherical particles is the build-up of a polymer on the solid core, so called "core-shell" polymerization [12]. Apart from spherical particles, one can also find sorbents with a thin layer of polymer surface coated on a solid support, e.g.…”

Section: Methodology Of Preparation Of Porous Molecularly Imprinted Pmentioning

confidence: 99%

Magnetic molecular imprinted polymers as a tool for isolation and purification of biological samples

2015

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Technology of molecularly imprinted polymers (MIP) has become very popular in recent decades. MIPs are primarily used in medical diagnostics, chromatographic separation and solid phase extraction (SPE); also as sensors and catalysts. In recent years there have been reported benefits of combining molecular imprinted polymers with additional features, e.g. magnetic properties, through the build-up of this type of material on magnetite particles (Magnetic Molecularly Imprinted Polymer -MMIP). This method produces a multifunctional material which has high selectivity and the ability to isolate the analyte from biological and environmental samples, allowing effective purification from such interferents as proteins and fats. This developing branch of new materials for the preparation and purification of complex sample matrices is an interesting alternative to materials routinely used to date, particularly with regard to the immunosorbents. This paper summarizes recent reports regarding MMIP preparation and their application for purification and isolation of compounds from biological matrices.

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Section: Methodology Of Preparation Of Porous Molecularly Imprinted Pmentioning

confidence: 99%

Magnetic molecular imprinted polymers as a tool for isolation and purification of biological samples

2015

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“…To remove the inhibitor prior to polymerisation, methacrylic acid (MAA) was distilled under vacuum, while methyl methacrylate (MMA) and ethylene glycol dimethacrylate (EDMA) were washed with I M aqueous sodium hydroxyde, dried over MgSO 4 and stored with molecular sieves at 4 'C until required. Sodium dodecyl sulfate (SDS), ammonium peroxodisulfate (APS) and other solvents and reagents were used as received.…”

Section: Methodsmentioning

confidence: 99%

“…In aqueous environments imprinted particles of 2-50 micron have also been described using a 2-step swelling method [3]. Emulsion polymerisation has also been used to create imprinted nanoparticles in an aqueous environment using the combination of covalent-non covalent interaction or directed imprinting at the surface of particles based on hydrophobic interactions [4,5]. To date, it has not been combined with the classical non-covalent approach.…”

Section: Introductionmentioning

confidence: 99%

Molecular Imprinting of Polymeric Core-Shell Nanoparticles

Moral

Mayes

2002

MRS Proc.

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In order to evaluate the compatibility of structured nanoparticles produced by aqueous emulsion polymerisation with the non-covalent imprinting procedure, a number of imprinted polymeric nanoparticles have been synthesised by seeded emulsion polymerisation in the presence and absence of a porogenic solvent. Propranolol was chosen as the template molecule using methacrylic acid (MAA) and ethylene glycol dimethacrylate (EDMA) as functional monomer and crosslinker respectively. The influence of the porogen and the amount of template added was studied by measuring the capacity of the polymeric particles to rebind template both in organic and aqueous buffers by radioligand binding assay. By increasing the amount of template from 0.5 to 6% (mol/mol with respect to monomers) the specific rebinding was increased from 2% to 24% in aqueous buffer and to 31% in a toluene based assay. The influence of the porosity was also established when the rebinding was performed in an organic solvent.

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“…The bioengineered aptamers provide some advantages over natural host-guest systems, including higher packing density and improved structural flexibility. Another bio-inspired host-guest system studied extensively is based on molecular imprinting of polymer films (Greene et al, 2005, Levit et al, 2002, Perez et al, 2000, Piletsky et al, 2001, Priego-Capote et al, 2008, Yan et al, 2005, Ye et al, 2000 whereby the polymerization of a polymer is carried out in the presence of guest molecules. The latter are then released from the template, e.g.…”

Section: Bio-inspired Molecularly-templated Polymer Films For Biomarkmentioning

confidence: 99%

Detection of Oxidative Stress Biomarkers Using Novel Nanostructured Biosensors

Hepel¹,

Stobiecka²

2011

New Perspectives in Biosensors Technology and Applications

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Molecularly imprinted nanoparticles prepared by core-shell emulsion polymerization

Cited by 144 publications

References 31 publications

Magnetic molecular imprinted polymers as a tool for isolation and purification of biological samples

Magnetic molecular imprinted polymers as a tool for isolation and purification of biological samples

Molecular Imprinting of Polymeric Core-Shell Nanoparticles

Detection of Oxidative Stress Biomarkers Using Novel Nanostructured Biosensors

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