Molecularly imprinted polymer for human viral pathogen detection

Malik, Aijaz Ahmad; Nantasenamat, Chanin; Piacham, Theeraphon

doi:10.1016/j.msec.2017.03.209

Cited by 55 publications

(36 citation statements)

References 37 publications

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“…MIPs/SIPs based biosensors have wide applications for the detection of virus in medical diagnostics. Malik and coworkers [62] summarized the state-of-the-art application of MIPs for virus detection.…”

Section: Detection Of Infectious Diseases Caused By Virusesmentioning

confidence: 99%

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Cui

Zhou

2020

Sensors

160

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Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted polymers (MIPs) and surface imprinted polymers (SIPs) have great potential to be robust artificial receptors. Therefore, extensive studies have been reported to develop MIPs/SIPs for the detection of infectious diseases with high selectivity and reliability. In this review, we discuss mechanisms of recognition events between imprinted polymers with different biomarkers, such as signaling molecules, microbial toxins, viruses, and bacterial and fungal cells. Then, various preparation methods of MIPs/SIPs for electrochemical biosensors are summarized. Especially, the methods of electropolymerization and micro-contact imprinting are emphasized. Furthermore, applications of MIPs/SIPs based electrochemical biosensors for infectious disease detection are highlighted. At last, challenges and perspectives are discussed.

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Section: Detection Of Infectious Diseases Caused By Virusesmentioning

confidence: 99%

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Cui

Zhou

2020

Sensors

160

View full text Add to dashboard Cite

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“…Millions of people suffer from several diseases due to numerous medical problems [11]. Today, there is a noteworthy rise in the infectious diseases that affect humans, animals, and plants [12]. Particularly, in undeveloped countries, various diseases, including human immunodeficiency virus (HIV), malaria, and tuberculosis, affect a lot of people [13].…”

Section: Introductionmentioning

confidence: 99%

Virus detection using nanosensors

Saylan

Deni̇zli̇

2020

Nanosensors for Smart Cities

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“…The majority of papers published to date on virus imprinting have been in the development of MIP-based virus diagnostics and sensors (Hayden et al, 2003; Perozo et al, 2006; Malitesta et al, 2012; Altintas et al, 2015; Malik et al, 2017; Ahmad et al, 2019; Tancharoen et al, 2019). Typically, a surface stamping method has been used to imprint for example tobacco mosaic virus, parapoxvirus ovis, and human rhinovirus.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Molecularly Imprinted Polymers as Synthetic Virus Neutralizing Antibody Mimics

Graham

EL-Sharif

Hussain

et al. 2019

Front. Bioeng. Biotechnol.

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Rapid development of antibody-based therapeutics are crucial to the agenda of innovative manufacturing of macromolecular therapies to combat emergent diseases. Although highly specific, antibody therapies are costly to produce. Molecularly imprinted polymers (MIPs) constitute a rapidly-evolving class of antigen-recognition materials that act as synthetic antibodies. We report here on the virus neutralizing capacity of hydrogel-based MIPs. We produced MIPs using porcine reproductive and respiratory syndrome virus (PRRSV-1), as a model mammalian virus. Assays were performed to evaluate the specificity of virus neutralization, the effect of incubation time and MIP concentration. Polyacrylamide and N-hydroxymethylacrylamide based MIPs produced a highly significant reduction in infectious viral titer recovered after treatment, reducing it to the limit of detection of the assay. MIP specificity was tested by comparing their neutralizing effects on PRRSV-1 to the effects on the unrelated bovine viral diarrhea virus-1; no significant cross-reactivity was observed. The MIPs demonstrated effective virus neutralization in just 2.5 min and their effect was concentration dependent. These data support the further evaluation of MIPs as synthetic antibodies as a novel approach to the treatment of viral infection.

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Molecularly imprinted polymer for human viral pathogen detection

Cited by 55 publications

References 37 publications

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Virus detection using nanosensors

Evaluation of Molecularly Imprinted Polymers as Synthetic Virus Neutralizing Antibody Mimics

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