Molecularly imprinted polymer-high performance liquid chromatography for the determination of tetracycline drugs in animal derived foods

Feng, Meng Xiao; Wang, Geng Nan; Yang, Kun; Liu, Hui Zhi; Wang, Jian Ping

doi:10.1016/j.foodcont.2016.04.050

Cited by 115 publications

(36 citation statements)

References 30 publications

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“…The proposed analytical method presented good performance when compared with other methods recently published as shown in S9. The obtained LOQs and LODs were equal or even lower.…”

Section: Resultsmentioning

confidence: 73%

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Graphene particles supported on silica as sorbent for residue analysis of tetracyclines in milk employing microextraction by packed sorbent

et al. 2018

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This paper describes the use of graphene-based sorbents for determination of four tetracyclines in milk. The synthesized materials were combined with microextraction by packed sorbent (MEPS) to act as the sample preparation step. The extraction performance of these sorbents was compared to commercial phases, and graphene supported on silica provided the best results. The analytical method optimization was carried out by employing experimental design. Firstly, an evaluation of the experimental variables (elution solvent, use of EDTA, ionic force, and pH of the washing solution) was made by a 2 factorial experimental design. The variables sampling, washing and elution cycles of MEPS were further optimized under a full 2 experimental design. The validation parameters were determined under optimized conditions resulting in a linearity ranging from 15 to 110 μg/L with R values above 0.98, and LOQs ranging from 0.05 to 0.9 μg/L. The accuracy ranged from 87.9 to 118.4% and intra/inter-day precision reported by the RSDs were lower than 19%. The proposed and validated method was successfully applied to the analysis of 11 milk samples from different animals, revealing traces of tetracyclines in only two of them. This study focused on the evaluation of graphene-based sorbents combined with MEPS for tetracycline analysis provided equivalent or even better results than other proposed methods, suggesting being a sensitive, fast and reliable alternative method for the determination of tetracyclines in milk samples.

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“…The proposed analytical method presented good performance when compared with other methods recently published as shown in S9. The obtained LOQs and LODs were equal or even lower.…”

Section: Resultsmentioning

confidence: 73%

“…Although other techniques and detectors are also available for such application, including the use of ultraviolet, fluorescence and chemiluminescence as HPLC detectors , LC‐MS/MS is by far the most important technique now available for TC's determination in food matrices .…”

Section: Introductionmentioning

confidence: 99%

Graphene particles supported on silica as sorbent for residue analysis of tetracyclines in milk employing microextraction by packed sorbent

et al. 2018

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“…MIPs are synthesized by crosslinking the crosslinker and functional monomers which can be combined with a template molecule by noncovalent bonds, such as hydrogen bonds or ionic bonds. The cavums remaining in the polymer can specifically capture the template molecule and its structurally related molecules when the template molecules are removed from the polymer (Feng, Wang, Yang, Liu, & Wang, ). MIPs have been applied in various harsh conditions (such as high pressure, high temperature and extremes of pH) and presented a promising physiochchemical stability (Feng et al, ; Li et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…The cavums remaining in the polymer can specifically capture the template molecule and its structurally related molecules when the template molecules are removed from the polymer (Feng, Wang, Yang, Liu, & Wang, ). MIPs have been applied in various harsh conditions (such as high pressure, high temperature and extremes of pH) and presented a promising physiochchemical stability (Feng et al, ; Li et al, ). Molecularly imprinted solid‐phase extraction (MISPE) based purification methods have been widely used to determine the trace drug in the environment (Zunngu, Madikizela, Chimuka, & Mdluli, ; Madikizela & Chimuka, ; Martinez‐Sena, Armenta, Guardia, & Esteve‐Turrillas, ; Li et al, ; Xu, Duhoranimana, & Zhang, ).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation of dummy template‐imprinted polymers for the rapid extraction of nonsteroidal anti‐inflammatory drugs residues in aquatic environmental samples

Zhang

Chen

Zhao

2018

Biomedical Chromatography

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A molecularly imprinted polymer was synthesized and applied as a sorbent in the solid-phase extraction device. The imprinted polymer was characterized by fourier-transform infrared spectroscopy and scanning electron microscope. The results revealed that imprinted polymer possess sensitive selectivity and reliable adsorption properties for five NSAIDs. The imprinted polymer was successfully applied to the pre-concentration for five NSAIDs in different water samples prior to UPLC-MS/MS. In the early studies, several factors were investigated, including pH adjustment, the kind of elution solvent and the volume of elution solvent. Finally, we found that the pH 5 and an aliquot of 2 mL methanol were suitable for the water samples. The limits of detection and limits of quantitation of five nonsteroidal anti-inflammatory drugs varied from 0.007 to 0.480 μg L and 0.03 to 1.58 μg L , respectively. The spiking recoveries of the target analytes were 50.33-127.64% at the levels of 0.2 μg L , 2 μg L and 5 μg L . The precision and accuracy of this method showed a great increase compared with traditional solid-phase extraction. The developed method was successfully applied to extraction and analysis of NSAIDs in different water samples with satisfactory results which could help us better understand their environmental fate and risk to ecological health.

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Smart Materials for Solid‐Phase Extraction Applications

Carrasco-Correa

Vergara-Barberán

Herrero‐Martínez

2019

Handbook of Smart Materials in Analytical Chemistry

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Molecularly imprinted polymer-high performance liquid chromatography for the determination of tetracycline drugs in animal derived foods

Cited by 115 publications

References 30 publications

Graphene particles supported on silica as sorbent for residue analysis of tetracyclines in milk employing microextraction by packed sorbent

Graphene particles supported on silica as sorbent for residue analysis of tetracyclines in milk employing microextraction by packed sorbent

Preparation of dummy template‐imprinted polymers for the rapid extraction of nonsteroidal anti‐inflammatory drugs residues in aquatic environmental samples

Smart Materials for Solid‐Phase Extraction Applications

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