Molecularly Imprinted Polymer Micro- and Nano-Particles: A Review

Fresco‐Cala, Beatriz; Batista, Alex D.; Cárdenas, Soledad

doi:10.3390/molecules25204740

Cited by 77 publications

(35 citation statements)

References 122 publications

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“…Chemical synthesis enables to synthesize micro- and nano-particles of conducting polymers that could be useful for the formation of MIP-based structures required for sensors, affinity chromatography [ 58 ] and some other technological purposes [ 59 ]. When the synthesis of CPs is completed, spin-coating techniques [ 60 ] can be applied to deposit polymer layer on the surface of signal transducer.…”

Section: Oxidative-chemical Polymerization Based Synthesis and Promentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

2021

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Recent challenges in biomedical diagnostics show that the development of rapid affinity sensors is very important issue. Therefore, in this review we are aiming to outline the most important directions of affinity sensors where polymer-based semiconducting materials are applied. Progress in formation and development of such materials is overviewed and discussed. Some applicability aspects of conducting polymers in the design of affinity sensors are presented. The main attention is focused on bioanalytical application of conducting polymers such as polypyrrole, polyaniline, polythiophene and poly(3,4-ethylenedioxythiophene) ortho-phenylenediamine. In addition, some other polymers and inorganic materials that are suitable for molecular imprinting technology are also overviewed. Polymerization techniques, which are the most suitable for the development of composite structures suitable for affinity sensors are presented. Analytical signal transduction methods applied in affinity sensors based on polymer-based semiconducting materials are discussed. In this review the most attention is focused on the development and application of molecularly imprinted polymer-based structures, which can replace antibodies, receptors, and many others expensive affinity reagents. The applicability of electrochromic polymers in affinity sensor design is envisaged. Sufficient biocompatibility of some conducting polymers enables to apply them as “stealth coatings” in the future implantable affinity-sensors. Some new perspectives and trends in analytical application of polymer-based semiconducting materials are highlighted.

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Section: Oxidative-chemical Polymerization Based Synthesis and Promentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

2021

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“…It is thus necessary decreasing the size of the particles to enhance uptake kinetics, at the expense of difficulties in practically processing the sorption operations (more specifically proceeding the solid/liquid separation after sorbent saturation). This problem can be overcome by incorporation of magnetite nanoparticles for improving the ready separation of spent sorbent from treated solution [16,48,[55][56][57][58][59] using external magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Phosphorylation of Guar Gum/Magnetite/Chitosan Nanocomposites for Uranium (VI) Sorption and Antibacterial Applications

et al. 2021

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The development of new materials is needed to address the environmental challenges of wastewater treatment. The phosphorylation of guar gum combined with its association to chitosan allows preparing an efficient sorbent for the removal of U(VI) from slightly acidic solutions. The incorporation of magnetite nanoparticles enhances solid/liquid. Functional groups are characterized by FTIR spectroscopy while textural properties are qualified by N2 adsorption. The optimum pH is close to 4 (deprotonation of amine and phosphonate groups). Uptake kinetics are fast (60 min of contact), fitted by a pseudo-first order rate equation. Maximum sorption capacities are close to 1.28 and 1.16 mmol U g−1 (non-magnetic and magnetic, respectively), while the sorption isotherms are fitted by Langmuir equation. Uranyl desorption (using 0.2 M HCl solutions) is achieved within 20–30 min; the sorbents can be recycled for at least five cycles (5–6% loss in sorption performance, complete desorption). In multi-component solutions, the sorbents show marked preference for U(VI) and Nd(III) over alkali-earth metals and Si(IV). The zone of exclusion method shows that magnetic sorbent has antibacterial effects against both Gram+ and Gram- bacteria, contrary to non-magnetic material (only Gram+ bacteria). The magnetic composite is highly promising as antimicrobial support and for recovery of valuable metals.

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“…The correct chemical formation is required for the development of conducting polymer-based nano- or/and micro-particles suitable for the design of molecularly imprinted polymer-based layers used for chemical sensors and chromatographic systems, and many other purposes [ 37 , 38 ]. Electroactive polymers are used not only for sensor design [ 39 , 40 ] but also for tissue regeneration and some other biomedical purposes [ 41 ].…”

Section: Chemical Formation Of Conducting Polymers Based On Redox Pro...mentioning

confidence: 99%

Electrochemically Deposited Molecularly Imprinted Polymer-Based Sensors

Ramanavičius

Morkvėnaitė-Vilkončienė

Samukaitė-Bubnienė

et al. 2022

Sensors

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This review is dedicated to the development of molecularly imprinted polymers (MIPs) and the application of MIPs in sensor design. MIP-based biological recognition parts can replace receptors or antibodies, which are rather expensive. Conducting polymers show unique properties that are applicable in sensor design. Therefore, MIP-based conducting polymers, including polypyrrole, polythiophene, poly(3,4-ethylenedioxythiophene), polyaniline and ortho-phenylenediamine are frequently applied in sensor design. Some other materials that can be molecularly imprinted are also overviewed in this review. Among many imprintable materials conducting polymer, polypyrrole is one of the most suitable for molecular imprinting of various targets ranging from small organics up to rather large proteins. Some attention in this review is dedicated to overview methods applied to design MIP-based sensing structures. Some attention is dedicated to the physicochemical methods applied for the transduction of analytical signals. Expected new trends and horizons in the application of MIP-based structures are also discussed.

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Molecularly Imprinted Polymer Micro- and Nano-Particles: A Review

Cited by 77 publications

References 122 publications

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

Phosphorylation of Guar Gum/Magnetite/Chitosan Nanocomposites for Uranium (VI) Sorption and Antibacterial Applications

Electrochemically Deposited Molecularly Imprinted Polymer-Based Sensors

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