Molecularly imprinted polymer microspheres for solid‐phase extraction of protocatechuic acid in <i>Rhizoma homalomenae</i>

Chen, Fang‐Fang; Wang, Guoying; Shi, Yan‐Ping

doi:10.1002/jssc.201100463

Cited by 41 publications

(23 citation statements)

References 32 publications

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“…Described by many articles as therapeutic molecules active against several diseases, protocatechuic acid (Figure 2) was identified in plants like True roselle ( Hibiscus sabdariffa ), Rhizoma homalomenae, Spatholobus suberectus , and Alpinia oxyphylla (100–103, 179). …”

Section: The Venus Flytrap (Dionaea Muscipula Solander Ex Ellis)mentioning

confidence: 99%

Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer

Gaascht¹,

Dicato²,

Diederich³

2013

Front. Oncol.

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Chemoprevention uses natural or synthetic molecules without toxic effects to prevent and/or block emergence and development of diseases including cancer. Many of these natural molecules modulate mitogenic signals involved in cell survival, apoptosis, cell cycle regulation, angiogenesis, or on processes involved in the development of metastases occur naturally, especially in fruits and vegetables bur also in non-comestible plants. Carnivorous plants including the Venus flytrap (Dionaea muscipula Solander ex Ellis) are much less investigated, but appear to contain a wealth of potent bioactive secondary metabolites. Aim of this review is to give insight into molecular mechanisms triggered by compounds isolated from these interesting plants with either therapeutic or chemopreventive potential.

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Section: The Venus Flytrap (Dionaea Muscipula Solander Ex Ellis)mentioning

confidence: 99%

Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer

Gaascht¹,

Dicato²,

Diederich³

2013

Front. Oncol.

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“…Molecular imprinted polymers (MIP) have attracted wide attention and attained significant applications in selective extraction of polyphenols compounds and hydroxylated metabolites in plants, natural products, foodstuffs, or biological and environmental samples. However, MIP applications in the analytical determination of polyphenols metabolites have been limited and few of us used phenolic acid as a template [10,[13][14][15][16][17][18][19][20]. PCA has been used as template for the synthesis of an MIP for the extraction analogues compounds from plant in an Molecularly Imprinted Solid Phase Extraction (MISPE) procedure [13,14] or used as High-Performance Liquid Chromatography (HPLC)stationary phase to analyze synthetic samples of red wine [15,16].…”

Section: Introductionmentioning

confidence: 99%

A Molecularly Imprinted Polymer for Selective Extraction of Phenolic Acids from Human Urine

et al. 2021

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Studies for monitoring the bioavailability of dietary flavonoid compounds generate great interest. Among them, low-molecular-weight phenolic acids, secondary metabolites present in colonic catabolism and urinary excretion, have been proposed as biomarkers of polyphenol intake. Using 4-hydroxyphenylacetic acid as a template, a molecularly imprinted polymer (MIP) was synthesized for selective extraction of these hydroxylated metabolites from human urine samples and posterior analysis in an HPLC-DAD-MS system. Polymers were characterized by Scanning electron microscopy (SEM), Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), Brunauer-Emmett-Teller (BET) method, and binding experiments. MIP presents specific recognition ability for template and analogues molecules. This capacity of recognition and the pH dependence of the binding strength was also studied. The method was validated over a concentration range of 0.25–40 mg/L, r2 > 0.995. In the optimized conditions, the recovery value was 94% with RSD 1.2%. The Limit of Detection (LOD) and Limit of Quantification (LOQ) were 1.22 and 3.69 mg/L, respectively. In our knowledge, it is the first time that this methodology is applied to analyze urinary catabolites of the polyphenol compound and to provide a specific method and simple analysis alternative. The selective extraction of these metabolites improves the application and results obtained by other less sensitive analysis methods than the validation method. It also facilitates the development of new screening methods.

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“…Protocatechuic acid (3,4-dihydroxybenzoic acid) (PCA) is a widely-known naturally phenolic acid. PCA is similar in structure to gallic acid, caffeic acid and vanillic acid, which are typical antioxidant compounds, and is widespread in the plant kingdom [5,6,7]. PCA has been studied for its effects on human health such as antioxidant activity, anti-cancer, anti-fatigue, anti-arrhythmia, anti-inflammatory, antiviral activity, analgesics, active protection of the nerves and kidneys.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Chitosan Nanoparticles Loaded with Protocatechuic Acid (PCA) for the Resistance of Pyricularia oryzae Fungus against Rice Blast

et al. 2019

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In this study, chitosan nanoparticles were used as a carrier for Protocatechuic acid (PCA) to resist Pyricularia oryzae against rice blast. The final compound was characterized using zeta potentials for its surface electricity, Fourier transform infrared (FT-IR) analysis and transmission electron microscopy (TEM) were conducted for functional groups and for particle sizes and shape, respectively. The zeta potential results showed that loading PCA causes chitosan nanoparticle (CSNP) to decrease in surface electrons. The TEM images revealed that the particle size of chitosan (CS), although increasing in size when carrying PCA molecules, showed sufficient size for reasonable penetration into fungal cells. The FT-IR analysis showed that all functional group in CSNP carried PCA matched with previous studies. The antifungal test showed that diameters of inhibition zone of CS increases significantly after loading PCA, exhibiting the strongest antimicrobial effect on the Pyricularia oryzae fungus compared with weaker effects exhibited by CSNP alone or PCA. Our results suggested that CSNP loaded with PCA could be a potential compound for eradication of Pyricularia oryzae and that further testing on in vitro rice plants is recommended to reaffirm this possibility.

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Molecularly imprinted polymer microspheres for solid‐phase extraction of protocatechuic acid in Rhizoma homalomenae

Cited by 41 publications

References 32 publications

Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer

Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer

A Molecularly Imprinted Polymer for Selective Extraction of Phenolic Acids from Human Urine

Investigation of Chitosan Nanoparticles Loaded with Protocatechuic Acid (PCA) for the Resistance of Pyricularia oryzae Fungus against Rice Blast

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