Molecularly imprinted polymer microspheres for solid-phase extraction of chloramphenicol residues in foods

Shi, Xizhi; Wu, Aibo; Zheng, Sulian; Li, Rongxiu; Zhang, Dabing

doi:10.1016/j.jchromb.2006.10.057

Cited by 96 publications

(49 citation statements)

References 35 publications

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“…5 ng/mL (n.r.) [56] Phtalate esters graphene and CNT/CNF-G nanostructures Water 10 mL reduced to dry 0.02 ng/mL (0.004 ng/mL) [57] Parabens graphene supported on aminopropyl silica Water 1 mL 0.2 μg/mL (n.r.) [58] n.r.…”

Section: Micro Extraction By Packed Sorbent Procedures (Meps)mentioning

confidence: 99%

“…After the extraction the unit is recovered for the final instrumental analysis. When chromatographic techniques are employed, the analytes must be eluted with a proper solvent [57,58]. However, the configuration of the unit allows for the detachment of the film after the extraction for its direct spectroscopic analysis, avoiding the dilution inherent to the elution step [59,60].…”

Section: Stir Disk Extractionsmentioning

confidence: 99%

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Trends in Microextraction Techniques for Sample Preparation

2018

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Section: Micro Extraction By Packed Sorbent Procedures (Meps)mentioning

confidence: 99%

Section: Stir Disk Extractionsmentioning

confidence: 99%

Trends in Microextraction Techniques for Sample Preparation

2018

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“…Molecular imprinting is not a new know-how and its technology originated 70-80 years ago but has changed and improved significantly during this period (5). At the beginning, these polymers were applied in different chemical purification and analytical separation techniques and processes (6)(7)(8), as scavenger for undesired compounds in food industries (9), as a tool for drug discovery (10), and as enzyme-like catalysts (11). Recently, MIPs are considered as a drug delivery tool as not only they can have better control on drug release in comparison to conventional polymers due to their selective affinity to the host molecule but also they can achieve responsiveness to environmental conditions by employing responsive comonomers in their structure and hence regulate the drug release from the polymeric network (12).…”

Section: Introductionmentioning

confidence: 99%

Development of Molecularly Imprinted Olanzapine Nano-particles: In Vitro Characterization and In Vivo Evaluation

et al. 2016

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Abstract. Molecularly imprinted nano-particles (MINPs) selective for olanzapine were prepared using methacrylic acid (MA) as monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker, and 2,2-azobis (2-isobutyronitrile) (AIBN) as the initiator in 36 different ratios. The reaction runs with considerable fine powder formation were selected for further binding and selectivity studies. The MINP with the best selectivity (MINP-32) was chosen for further structural characterization by Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), adsorption-desorption isotherm for specific surface area, volume and average pore diameter determination. All characterization methods confirmed the successful formation of MINP. The optimum conditions for maximum template loading on the MINP-32 were found by experimental design using response surface methodology (RSM) and choosing absorbent amount, pH, and time as the main factors. MINPs with maximum template loading also indicated significant selectivity between template and its analog (clozapine). The release profile demonstrated a maximum release of about 95% after 288 h for MINP-32 in comparison with about 94% after 120 h for non-MINP-32. The same slow release of drug from MINP-32 was also observed during animal study of the plasma level of template, 20-28 μg/ml versus 5-10 μg/ml. The MINP-32 of this study represents a desirable ability to keep the memory of the template with significant selectivity and good capability to control the release of template in vitro and in vivo and hence could be a promising drug delivery system.

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“…However, it was found that CAP had serious adverse effects against human bodies, leading to bone marrow depression and even aplastic anemia [1][2]. Due to these side effects, it was banned from use in animal feeds and food in the European Union (EU), Switzerland, USA and other countries [3][4].…”

Section: Introductionmentioning

confidence: 99%

Gold Magnetic Nanoparticles-based Chemiluminescent Immunoassay for Detection of Chloramphenicol in Milk

et al. 2016

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Abstract. chemiluminescent immunoassays (CLIA) based on gold magnetic nanoparticles (Au-MNPs) were developed for rapid analysis of chloramphen icol (CAP) in milk sample. Anti-CAP antibodies were immobilized on the surfaces of Au-MNPs, luminol (Method I) and 2',6'-DiMethylcarbonylphenyl-10-sulfopropylacridinium-9-carboxylate 4'-NHS Ester, (NSP-DMAE-NHS, Method II) were exploited in competitive CLIA for CAP detection in milk using a homemade luminescent measurement system. The sensitivities and limits of detection (LODs) of the two methods were obtained according to the inhibition curves. It indicated that NSP-DMAE-NHS as luminescence reagent (reaction II) was more sensitive and effective than luminol (reaction I). The LOD of reaction II reached 0.008 ng/ml while it was 4 ng/ml in reaction I. Moreover, the linear range of the inhibition curve of the former was wider than that of the latter. Such results indicated that the proposed CLIA stratery employing NSP-DMAE-NHS was more sensitive than other immunoassay method for CAP detection.

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Molecularly imprinted polymer microspheres for solid-phase extraction of chloramphenicol residues in foods

Cited by 96 publications

References 35 publications

Trends in Microextraction Techniques for Sample Preparation

Trends in Microextraction Techniques for Sample Preparation

Development of Molecularly Imprinted Olanzapine Nano-particles: In Vitro Characterization and In Vivo Evaluation

Gold Magnetic Nanoparticles-based Chemiluminescent Immunoassay for Detection of Chloramphenicol in Milk

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