Molecularly imprinted polymer specific to creatinine complex with copper(II) ions for voltammetric determination of creatinine

Alizadeh, Taher; Mousavi, Z.

doi:10.1007/s00604-022-05470-8

Cited by 9 publications

(4 citation statements)

References 46 publications

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“…The sensor was tested with similar compounds of creatinine (e.g., caffeine, uric acid, and melamine) and showed selectivity to creatinine. A good agreement was obtained with the results from human plasma samples spiked with creatinine evaluated with the sensor and with HPLC [90]. Furthermore, Sergeyeva et al fabricated a colorimetric MIP sensor for the detection of creatinine by the immersion of a poly(vinylidene difluoride) (PVDF) membrane (pores of 0.22 µm) into a mixture of creatinine (template), itaconic acid (IA, monomer), MAA (monomer), 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPSA, monomer), and MBA (crosslinker) subjected to UV (365 nm) for 10 min.…”

Section: Creatininesupporting

confidence: 74%

Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes

Ostrovidov

Ramalingam

Bae

et al. 2023

Sensors

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Molecularly imprinted polymers (MIPs) are synthetic polymers with specific binding sites that present high affinity and spatial and chemical complementarities to a targeted analyte. They mimic the molecular recognition seen naturally in the antibody/antigen complementarity. Because of their specificity, MIPs can be included in sensors as a recognition element coupled to a transducer part that converts the interaction of MIP/analyte into a quantifiable signal. Such sensors have important applications in the biomedical field in diagnosis and drug discovery, and are a necessary complement of tissue engineering for analyzing the functionalities of the engineered tissues. Therefore, in this review, we provide an overview of MIP sensors that have been used for the detection of skeletal- and cardiac-muscle-related analytes. We organized this review by targeted analytes in alphabetical order. Thus, after an introduction to the fabrication of MIPs, we highlight different types of MIP sensors with an emphasis on recent works and show their great diversity, their fabrication, their linear range for a given analyte, their limit of detection (LOD), specificity, and reproducibility. We conclude the review with future developments and perspectives.

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Section: Creatininesupporting

confidence: 74%

Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes

Ostrovidov

Ramalingam

Bae

et al. 2023

Sensors

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“…Moreover, Cu 2+ ions have a high charge density to carry four creatinine molecules via high coordination number through endocyclic nitrogen atoms of creatinine molecules. 43 However, no significant change in reduction peak current was ascribed to the fact that Cu( i ) has less affinity for CRE molecules because Cu( i ) prefers complexes with low coordination number, which takes place through many structural and stereochemical changes of the complexes. 44 As a result, in reverse scan there is no complex formation taking place with Cu + .Cu (0) → Cu 2+ Cu 2+ + (CRE) → Cu-CRE complex (soluble)…”

Section: Resultsmentioning

confidence: 99%

Flexible electrochemical sensor for highly sensitive and selective non-enzymatic detection of creatinine via electrodeposited copper over polymelamine formaldehyde

Mehta,

Kafle,

Nagaiah

2023

J. Mater. Chem. B

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“…Molecularly imprinted polymer (MIP) is a polymeric matrix with cavities, which simulates the interaction between antibodyantigen to bind with the specific biomarkers. [19,20] MIP-based biosensors have been developed over recent years for the ultrasensitive detection of various biomarkers, [21,22] including creatinine, urea, and HSA, [23][24][25] with excellent sensitivity and selectivity for direct measurements in clinical samples. However, the intrinsic disadvantages of the traditional MIP biosensors still re-main, mainly with binding sites heterogeneity and slow diffusion mass transfer of analytes to the imprinted sites affecting their overall performance.…”

Section: Introductionmentioning

confidence: 99%

A Point‐of‐Care Sensing Platform for Multiplexed Detection of Chronic Kidney Disease Biomarkers Using Molecularly Imprinted Polymers

Li,

Luo,

Kong

et al. 2024

Adv Funct Materials

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Chronic kidney disease (CKD) is one of the most serious non‐communicable diseases affecting the population. In the early‐stages patients have no obvious symptoms, until it becomes life‐threatening leading end‐stage kidney failure. Therefore, it is important to early diagnose CKD to allow therapeutic interventions and progression monitoring. Here, a point‐of‐care (POC) sensing platform is reported for the simultaneous detection of three CKD biomarkers, namely creatinine, urea, and human serum albumin (HSA), using reduced graphene oxide/polydopamine‐molecularly imprinted polymer (rGO/PDA‐MIP) fabricated with novel surface‐molecularly imprinting technology. A multi‐channel electrochemical POC readout system with differential pulse voltammetry (DPV) function is developed, allowing the simultaneous detection of the three biomarkers, in combination with the surface‐MIP electrodes. This sensing platform achieves the record low limit‐of‐detection (LoD) at a femtomolar level for all three analytes, with wide detection ranges covering their physiological concentrations. Clinical validation is performed by measuring these analytes in serum and urine from healthy controls and patients with CKD. The average recovery rate is 81.8–119.1% compared to the results obtained from the hospital, while this platform is more cost‐effective, user‐friendly, and requires less sample‐to‐result time, showing the potential to be deployed in resource‐limited settings for the early diagnosis and tracking progression of CKD.

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Molecularly imprinted polymer specific to creatinine complex with copper(II) ions for voltammetric determination of creatinine

Cited by 9 publications

References 46 publications

Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes

Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes

Flexible electrochemical sensor for highly sensitive and selective non-enzymatic detection of creatinine via electrodeposited copper over polymelamine formaldehyde

A Point‐of‐Care Sensing Platform for Multiplexed Detection of Chronic Kidney Disease Biomarkers Using Molecularly Imprinted Polymers

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