Molecularly imprinted polymers: synthesis and characterisation

Cormack, Peter A. G.; Elorza, Amaia Zurutuza

doi:10.1016/j.jchromb.2004.02.013

Cited by 497 publications

(348 citation statements)

References 6 publications

(6 reference statements)

Supporting

Mentioning

285

Contrasting

Unclassified

Order By: Relevance

“…Ideally those interactions should be strong so that the recognition mechanism after the synthesis of the polymer could be enhanced. Suitable species should be chosen carefully in order to produce the highest number of well-defined binding sites [30].…”

Section: Templatementioning

confidence: 99%

Applications of molecularly imprinted polymers to the analysis and removal of personal care products: A review

Figueiredo

Erny

Santos

et al. 2016

Talanta

145

View full text Add to dashboard Cite

Personal-care products (PCPs) involve a variety of chemicals whose persistency along with their constant release into the environment raised concern to their potential impact on wildlife and humans health. Regarded as emergent contaminants, PCPs demonstrated estrogenic activity leading to the need of new methodologies to detect and remove those compounds from the environment.Molecular imprinting starts with a complex between a template molecule and a functional monomer, which is then polymerized in the presence of a cross-linker. After template removal, the polymer will contain specific cavities. Based on a good selectivity towards the template, molecularly imprinted polymers (MIPs) have been investigated as efficient materials for the analysis and extraction of the so called emergent pollutants contaminants.Rather than lowering the limit of detections, the key theoretical advantage of MIP over existing methodologies is the potential to target specific chemicals. This unique feature, sometime named specificity (as synonym to very high selectivity) allows to use cheap, simple and/or rapid quantitative techniques such as fast separation with ultra-violet (UV) detection, sensors or even spectrometric techniques. When a high degree of selectivity is achieved samples extracted with MIPs can be directly analysed without the need of a separation step. However, while some papers clearly demonstrated the specificity of their MIP toward the targeted PCP, such prove is often lacking, especially with real matrices, making it difficult to assess the success of the different approaches.This review paper focusses on the latest development of MIPs for the analysis of personal care products in the environment, with particular emphasis on design, preparation and practical applications of MIPs.3

show abstract

Section: Templatementioning

confidence: 99%

Applications of molecularly imprinted polymers to the analysis and removal of personal care products: A review

Figueiredo

Erny

Santos

et al. 2016

Talanta

145

View full text Add to dashboard Cite

show abstract

“…To circumvent these issues, the authors turned to the aid of molecularly imprinted polymers (MIPs) designed to specifically recognize theobromine for isolation of starting materials and products of P450 3A4 reactions [72]. Imprinted polymers are generated by polymerization of monomers and cross-linkers in the presence of a template [73]. The MIPs are expected to have high affinity for molecules resembling the template and can serve to extract such molecules (referred to as target molecules) from a complex mixture [74][75][76][77][78][79][80][81].…”

Section: Mammalian P450smentioning

confidence: 99%

Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates

Auclair

Polic

2015

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Cytochrome P450 enzymes (P450s) have the ability to oxidize unactivated C-H bonds of substrates with remarkable regio-and stereoselectivity. Comparable selectivity for chemical oxidizing agents is typically difficult to achieve. Hence, there is an interest in exploiting P450s as potential biocatalysts. Despite their impressive attributes, the current use of P450s as biocatalysts is limited. While bacterial P450 enzymes typically show higher activity, they tend to be highly selective for one or a few substrates. On the other hand, mammalian P450s, especially the drugmetabolizing enzymes, display astonishing substrate promiscuity. However, product prediction continues to be challenging. This review discusses the use of small molecules for controlling P450 substrate specificity and product selectivity. The focus will be on two approaches in the area: (1) the use of decoy molecules, and (2) the application of substrate engineering to control oxidation by the enzyme.

show abstract

“…A reação ocorre na ausência de oxigênio sob fluxo de N 2 ou Ar e induzida com aquecimento e/ou radiação UV. O oxigênio deve ser eliminado do meio reacional, pois retarda a reação de polimerização radicalar 30 . Por fim, o sólido polimérico resultante é moído, peneirado e submetido a uma lavagem com solvente para extração do analito, visando seu uso posterior 17,31 (Figura 2).…”

Section: Estado Da Arte No Preparo Dos Mipunclassified

“…Por fim, o sólido polimérico resultante é moído, peneirado e submetido a uma lavagem com solvente para extração do analito, visando seu uso posterior 17,31 (Figura 2). O iniciador radicalar 2,2'-azo-bis-iso-butironitrila (AIBN) é o mais empregado na síntese dos MIP, mas outros também podem ser utilizados 30 (Figura 3). A escolha destes reagentes é ditada pela natureza da interação do analito com o monômero.…”

Section: Estado Da Arte No Preparo Dos Mipunclassified

See 1 more Smart Citation

Polímeros biomiméticos em química analítica. Parte 1: preparo e aplicações de MIP ("Molecularly Imprinted Polymers") em técnicas de extração e separação

2005

View full text Add to dashboard Cite

Molecularly imprinted polymers: synthesis and characterisation

Cited by 497 publications

References 6 publications

Applications of molecularly imprinted polymers to the analysis and removal of personal care products: A review

Applications of molecularly imprinted polymers to the analysis and removal of personal care products: A review

Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates

Polímeros biomiméticos em química analítica. Parte 1: preparo e aplicações de MIP ("Molecularly Imprinted Polymers") em técnicas de extração e separação

Contact Info

Product

Resources

About