Molecularly targeted radiosensitization chances towards gene aberration-due organ confined/regionally advanced prostate cancer radioresistance

Alberti, C

doi:10.11138/gchir/2015.36.3.133

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…Upon ligand-binding, the expression of anti-apoptotic and pro-angiogenic factors is increased and a number of cancer cells undergo trans-differentiation to neuroendocrine-like cells and stimulate angiogenesis, neovascularization, and invasion contributing to prostate cancer progression and therapy resistance [158]. The use of β2-AR antagonist ICI 118,551 may overcome prostate cancer radioresistance [159].…”

Section: Stress Hormones Can Induce Neuroendocrine Differentiationmentioning

confidence: 99%

Highlighting the Potential for Chronic Stress to Minimize Therapeutic Responses to Radiotherapy through Increased Immunosuppression and Radiation Resistance

Chen

Singh

2020

Cancers

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Ionizing radiation has been used in the treatment of cancer for more than 100 years. While often very effective, there is still a great effort in place to improve the efficacy of radiation therapy for controlling the progression and recurrence of tumors. Recent research has revealed the close interaction between nerves and tumor progression, especially nerves of the autonomic nervous system that are activated by a variety of stressful stimuli including anxiety, pain, sleep loss or depression, each of which is likely to be increased in cancer patients. A growing literature now points to a negative effect of chronic stressful stimuli in tumor progression. In this review article, we present data on the potential for adrenergic stress to influence the efficacy of radiation and in particular, its potential to influence the anti-tumor immune response, and the frequency of an “abscopal effect” or the shrinkage of tumors which are outside an irradiated field. We conclude that chronic stress can be a major impediment to more effective radiation therapy through mechanisms involving immunosuppression and increased resistance to radiation-induced tumor cell death. Overall, these data highlight the potential value of stress reduction strategies to improve the outcome of radiation therapy. At the same time, objective biomarkers that can accurately and objectively reflect the degree of stress in patients over prolonged periods of time, and whether it is influencing immunosuppression and radiation resistance, are also critically needed.

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Section: Stress Hormones Can Induce Neuroendocrine Differentiationmentioning

confidence: 99%

Highlighting the Potential for Chronic Stress to Minimize Therapeutic Responses to Radiotherapy through Increased Immunosuppression and Radiation Resistance

Chen

Singh

2020

Cancers

View full text Add to dashboard Cite

show abstract

Molecularly targeted radiosensitization chances towards gene aberration-due organ confined/regionally advanced prostate cancer radioresistance

Abstract: SUMMARY: Molecularly targeted radiosensitization chances towards gene aberration-due organ confined/regionally advanced prostate cancer radioresistance. C. ALBERTI Considering that the prostate cancer radioresistance occurs in a si

Cited by 1 publication

References 16 publications

Highlighting the Potential for Chronic Stress to Minimize Therapeutic Responses to Radiotherapy through Increased Immunosuppression and Radiation Resistance

Highlighting the Potential for Chronic Stress to Minimize Therapeutic Responses to Radiotherapy through Increased Immunosuppression and Radiation Resistance

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