Mollaret meningitis

Wright, William F.; Palisoc, Kathryn; Baghli, Salim

doi:10.1016/j.jns.2018.11.018

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…In summary, the clinical course of the viral infections in this patient and in his son [16] were unusual, even though similar courses have also rarely been reported in patients without obvious immunodeficiency. This had, however, not been completely ruled out in the latter reports [8,19,20].…”

Section: Discussionmentioning

confidence: 98%

A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans

Körholz

Richter²,

Schäfer³

et al. 2020

Mol Cell Pediatr

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Background Unlike infections with mycobacteria, reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce. Therefore, discussion about increased susceptibility to viral infections in these patients is ongoing. Case presentation We describe a 51-year-old male with dominant partial interferon-gamma-receptor-1 (IFNγR1)-deficiency and recurrent Herpes simplex 2 meningoencephalitis as well as other viral reactivations since childhood. Conclusions This case further confirms an enhanced risk for viral disease in IFNγR-deficient patients and a role of interferon gamma for human antiviral defense.

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Section: Discussionmentioning

confidence: 98%

A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans

Körholz

Richter²,

Schäfer³

et al. 2020

Mol Cell Pediatr

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“…But with the development of etiology, there is a tendency to make etiological diagnosis for those who can find the cause. For example, the relevant virus "recurrent viral meningitis", and the term "MM" should be limited to idiopathic recurrent aseptic meningitis (Wright et al, 2019). As for etiological diagnosis, at present, it mainly aimed at the detection of possible pathogenic microorganisms.…”

Section: Clinical Datamentioning

confidence: 99%

A case report of benign recurrent aseptic meningitis and literature review

Qiu¹,

Dai²,

Hua³

et al. 2022

Food Sci. Technol

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Benign recurrent meningitis, also known as Mollaret's meningitis (MM), is characterized by recurrent headache, fever, meningeal irritation and sterility of cerebrospinal fluid examination, which is rare in clinic. Although with clear diagnostic criteria, there are still many unclear aspects of its pathogenesis, and treatment of this disease. The author reported a case of benign recurrent aseptic meningitis, who had three episodes of acute headache with or without fever. The patient was treated with ceftriaxone, acyclovir and cefazoxime for the first time, cefazoxime, cefimidazole and mebendazole for the second time, and piperacillin and acyclovir for the third time. The results showed that the patient did not recover completely in the first two times and fully recovered at the third time. Based on the current research, the author believes that for MM, mainly symptomatic relief, indomethacin should be recommended, and too much antiviral treatment is not needed.

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“…Notably, it was shown that activity of the innate immune system protects against neurological complications [176]. It was recently reported that herpes-simplex-virus-2 (HSV-2) patients with defects in the autophagy genes ATG4A and LC3B2 develop recurrent meningitis (Mollaret's meningitis), a recurrent or chronic form of inflammation of the protective membranes covering the CNS [177,178]. Mechanistically, autophagy mediates the clearance of HSV-2 antigen in non-defective cells.…”

Section: Innate Immune Responses In Post-acute Conditions Of Persistent Virusesmentioning

confidence: 99%

Implications of Innate Immunity in Post-Acute Sequelae of Non-Persistent Viral Infections

Hirschenberger

Hunszinger

Sparrer

2021

Cells

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Non-persistent viruses classically cause transient, acute infections triggering immune responses aimed at the elimination of the pathogen. Successful viruses evolved strategies to manipulate and evade these anti-viral defenses. Symptoms during the acute phase are often linked to dysregulated immune responses that disappear once the patient recovers. In some patients, however, symptoms persist or new symptoms emerge beyond the acute phase. Conditions resulting from previous transient infection are termed post-acute sequelae (PAS) and were reported for a wide range of non-persistent viruses such as rota-, influenza- or polioviruses. Here we provide an overview of non-persistent viral pathogens reported to be associated with diverse PAS, among them chronic fatigue, auto-immune disorders, or neurological complications and highlight known mechanistic details. Recently, the emergence of post-acute sequelae of COVID-19 (PASC) or long COVID highlighted the impact of PAS. Notably, PAS of non-persistent infections often resemble symptoms of persistent viral infections, defined by chronic inflammation. Inflammation maintained after the acute phase may be a key driver of PAS of non-persistent viruses. Therefore, we explore current insights into aberrant activation of innate immune signaling pathways in the post-acute phase of non-persistent viruses. Finally, conclusions are drawn and future perspectives for treatment and prevention of PAS are discussed.

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Mollaret meningitis

Cited by 8 publications

References 5 publications

A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans

A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans

A case report of benign recurrent aseptic meningitis and literature review

Implications of Innate Immunity in Post-Acute Sequelae of Non-Persistent Viral Infections

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