Mollaret’s Syndrome: A Case Report

Abstract

Benign recurrent aseptic meningitis is a rare condition characterized by recurring, self-limited episodes of aseptic meningitis. Meningeal irritation typically occurs first, accompanied by fever and mononuclear cell pleocytosis. The diagnosis is only made after other known causes of lymphocytic meningitis have been excluded. Resolution typically occurs within two to seven days without residual neurological deficit. Aseptic meningitis is most frequently caused by viruses; Mollaret’s meningitis has been linked to the herpes simplex virus 2 (HSV 2). It is unclear if prophylactic medication is indicated for these patients. We describe a patient who was experiencing her seventh episode of aseptic meningitis.

Kikuchi disease-associated Mollaret meningitis with MEFV gene mutation successfully treated with colchicine

“…Mollaret meningitis is a rare neurological disorder that is characterized by recurrent episodes of aseptic meningitis and the presence of pathognomonic Mollaret cells, which are thought to be abnormal monocytes and are marked by large basophilic and cleaved nuclei, resembling a clover leaf 1 . Mollaret meningitis is caused by herpes simplex virus type 2 (HSV-2), systemic lupus erythematous and, familial Mediterranean fever (FMF) 2 .…”