Molluscum contagiosum

Rao, Kavita; Priya, NS; Umadevi, H S; Smitha, T

doi:10.4103/0973-029x.110726

Cited by 5 publications

(9 citation statements)

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“…On histopathological evaluation, MC classically presents as a lobulated crateriform lesion with acanthotic epidermis containing intracytoplasmic viral inclusions known as molluscum bodies (MBs) or Henderson–Paterson bodies. These homogeneous ground‐glass‐like inclusions range from basophilic to eosinophilic, and peripherally displace the cell nucleus, resulting in a signet‐ring appearance . MC has a tendency to infect follicular epithelium, and viral cores are first demonstrated in the basal layers of the epidermis .…”

Section: Introductionmentioning

confidence: 99%

“…These homogeneous ground-glass-like inclusions range from basophilic to eosinophilic, and peripherally displace the cell nucleus, resulting in a signet-ring appearance. 2,13,14 MC has a tendency to infect follicular epithelium, and viral cores are first demonstrated in the basal layers of the epidermis. 15 After inoculation, MCV regulates host cell transcription and replicates within the cytoplasm.…”

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confidence: 99%

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Histopathological features of molluscum contagiosum other than molluscum bodies

et al. 2015

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Histopathological features of molluscum contagiosum other than molluscum bodies

et al. 2015

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“…Haematoxylin and eosin staining of a molluscum contagiosum lesion typically reveals a crateriform, hyperplastic epidermis or endophytic infundibular hyperplasia that produces a circumscribed cup‐shaped pseudotumor containing large cells with granular, eosinophilic, intracytoplasmic molluscum bodies (also known as inclusion bodies or Henderson–Paterson bodies) 79 . Inclusion bodies are large, measure up to 35 microns in diameter and are made by millions of virions that compress the keratinocyte nuclei 80 . They progressively enlarge and become basophilic before being disseminated throughout the skin surface 80 .…”

Section: Histopathologymentioning

confidence: 99%

“…Inclusion bodies are large, measure up to 35 microns in diameter and are made by millions of virions that compress the keratinocyte nuclei 80 . They progressively enlarge and become basophilic before being disseminated throughout the skin surface 80 . Unusual histological patterns include pseudocystic, giant and pedunculated variants.…”

Section: Histopathologymentioning

confidence: 99%

2020 European guideline on the management of genital molluscum contagiosum

Edwards¹,

Boffa

Janier

et al. 2020

Acad Dermatol Venereol

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Molluscum contagiosum is a benign viral epidermal infection associated with high risk of transmission. The guideline is focused on the sexually transmitted molluscum contagiosum. The diagnosis is clinical with characteristic individual lesions, termed ‘mollusca’, seen as dome‐shaped, smooth‐surfaced, pearly, firm, skin‐coloured, pink, yellow or white papules, 2 ‐ 5 mm in diameter with central umbilication. Dermoscopy may facilitate diagnosis. Therapeutic options are numerous, including physical treatments (cautery, curettage and cryotherapy), topical chemical treatments (e.g. podophyllotoxin and imiquimod) or waiting for spontaneous resolution in immunocompetent patients. In pregnancy, it is safe to use physical procedures (e.g. cryotherapy). Immunosuppressed patients develop severe and recalcitrant molluscum lesions that may require treatment with cidofovir, imiquimod or interferon. Patients with molluscum contagiosum infection should be offered to be screened for other sexually transmitted infections.

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“…[ 9 ] Individual keratinocytes feature intra-cytoplasmic, basophilic viral inclusions called Molluscum bodies or Henderson-Paterson bodies. [ 10 ]…”

Section: Introductionmentioning

confidence: 99%