Molsidomine

Nitric Oxide Donors: Chemical Activities and Biological Applications

“…Sydnonimines were initially used as antihypertensive agents. , Molsidomine has been used in several European countries as an antianginal drug − One of the main advantages of molsidomine is the absence of tolerance. Whereas molsidomine itself is only poorly vasoactive in vitro, its metabolite SIN-1 is a potent vasorelaxant and antiplatelet agent.…”

Anionic N-heterocyclic carbenes derived from sydnone imines such as molsidomine. Trapping reactions with selenium, palladium, and gold

“…In continuation of our interest in sydnone derived carbenes 45 we report here on N-heterocyclic carbenes of two sydnone imines, among those the carbene of Molsidomine. This orally active vasodilating drug for the prevention of angina pectoris attacks 47 is the subject of intense ongoing pharmacological research, [48][49][50][51][52] however, during the last decade not much effort has been directed toward its chemical properties. We present some surprising results in the light of the relationship between mesomeric betaines and Nheterocyclic carbenes.…”

Drugs modulating the L-arginine:NO:cGMP pathway – current use in therapy

“…SIN -1 acts as a potent hypotensive and spasmolytic agent that is without influence on the autonomic nervous system. It only interacts directly with vascular smooth muscles and has a negative inotropic effect, reducing cardiac preload and afterload, as well as peripheral blood pressure [46].…”

“…These findings have guided research efforts towards NO therapy as treatment for post-menopausal osteoporosis [46]. The clinical trials that have been performed so far, however, have returned varied results.…”