Molybdenum in rat tissue

Pandey, Ratna; Kumar, Raj; Singh, S. P.; Srivastava, Sri Prakash

doi:10.1191/0960327102ht203oa

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…This is in accordance with the findings of Murray et al who reported no effects on hematological parameters after 90 days of sodium molybdate dihydrate feeding of Sprague-Dawley rats [30]. Contrasting these findings, Pandey et al investigated metal accumulation in the tissues of male rats who orally received 50 mg molybdenum per kg in eight consecutive doses and found significant Mo accumulation in blood cells, which they concluded as a possible risk for anemia [31]. However, the dose given in that study was much higher than the Mo released at the low degradation rates in our study.…”

Section: Blood Analyses and Inflammationsupporting

confidence: 88%

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Biocompatibility and Degradation Behavior of Molybdenum in an In Vivo Rat Model

et al. 2021

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The biocompatibility and degradation behavior of pure molybdenum (Mo) as a bioresorbable metallic material (BMM) for implant applications were investigated. In vitro degradation of a commercially available Mo wire (ø250 µm) was examined after immersion in modified Kokubo’s SBF for 28 days at 37 °C and pH 7.4. For assessment of in vivo degradation, the Mo wire was implanted into the abdominal aorta of female Wistar rats for 3, 6 and 12 months. Microstructure and corrosion behavior were analyzed by means of SEM/EDX analysis. After explantation, Mo levels in serum, urine, aortic vessel wall and organs were investigated via ICP-OES analysis. Furthermore, histological analyses of the liver, kidneys, spleen, brain and lungs were performed, as well as blood count and differentiation by FACS analysis. Levels of the C-reactive protein were measured in blood plasma of all the animals. In vitro and in vivo degradation behavior was very similar, with formation of uniform, non-passivating and dissolving product layers without occurrence of a localized corrosion attack. The in vitro degradation rate was 101.6 µg/(cm2·d) which corresponds to 33.6 µm/y after 28 days. The in vivo degradation rates of 12, 33 and 36 µg/(cm2·d) were observed after 3, 6 and 12 months for the samples properly implanted in the aortic vessel wall. This corresponds with a degradation rate of 13.5 µm/y for the 12-month cohort. However, the magnitude of degradation strongly depended on the implant site, with the wires incorporated into the vessel wall showing the most severe degradation. Degradation of the implanted Mo wire neither induced an increase in serum or urine Mo levels nor were elevated Mo levels found in the liver and kidneys compared with the respective controls. Only in the direct vicinity of the implant in the aortic vessel wall, a significant amount of Mo was found, which, however, was far below the amounts to be expected from degrading wires. No abnormalities were detected for all timepoints in histological and blood analyses compared to the control group. The C-reactive protein levels were similar between all the groups, indicating no inflammation processes. These findings suggest that dissolved Mo from a degrading implant is physiologically transported and excreted. Furthermore, radiographic and µCT analyses revealed excellent radiopacity of Mo in tissues. These findings and the unique combination with its extraordinary mechanical properties make Mo an interesting alternative for established BMMs.

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Section: Blood Analyses and Inflammationsupporting

confidence: 88%

“…None of the organs showed any pathological changes between the study and control animals. In animal studies of rats and guinea pigs, the highest Mo tissue concentrations after oral Mo intake were measured in the kidneys [30,31,34]. Murray et al reported no macroscopic pathological findings.…”

Section: Histological Organ Analysismentioning

confidence: 99%

Biocompatibility and Degradation Behavior of Molybdenum in an In Vivo Rat Model

et al. 2021

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“…Although naturally occurring Mo deficiency has never been demonstrated in free-living animals, Mo deficiency can be the result of low Mo levels in soil, plants, drinking water and other food items [e.g. 139 ]. Mo is known for its anticarcinogen properties, low concentrations being associated with oesophageal cancer in particular [e.g.…”

Section: Resultsmentioning

confidence: 99%

“…Mo is known for its anticarcinogen properties, low concentrations being associated with oesophageal cancer in particular [e.g. 139 – 141 ].…”

Section: Resultsmentioning

confidence: 99%

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Variability of the Ionome of Wild Boar (Sus scrofa) and Red Deer (Cervus elaphus) in a Dutch National Park, with Implications for Biomonitoring

Wenting,

Siepel,

Jansen

2023

Biol Trace Elem Res

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The ionome—an important expression of the physiological state of organisms—is poorly known for mammals. The focus on particular tissues—such as liver, kidney, and bones—in biomonitoring of environmental pollution and potential deficiencies is based on widely held assumptions rather than solid knowledge of full mammalian ionomes. We examined the full ionome of Red deer (Cervus elaphus) and Wild boar (Sus scrofa), two commonly used mammals for biomonitoring, in a Dutch protected nature reserve (Veluwezoom). We used four individuals per species. We dissected 13 tissues and organs from each individuals (eight in total) of each species and measured 22 elemental concentrations in each. We assessed, for each element, how concentrations varied across tissues within and between individuals. Based on existing literature, we put our findings in the context of their function in the mammalian body. We found that the ionome was highly variable between as well as within the two species. For most elements, tissues containing the highest and lowest concentration differed between individuals. No single tissue accurately represented the accumulation of toxic elements or potential deficiencies in the bodies. Our assessment of the element’s biological roles revealed a serious lack of reference values. Our findings imply that analyses of commonly used tissues in biomonitoring do not necessarily capture bioaccumulation of toxins or potential deficiencies. We recommend establishing a centralized database of mammalian ionomes to derive reference values in future. To our knowledge, our study is one of the most complete assessments of mammalian ionomes to date.

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